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anti-CHST1 antibody :: Rabbit CHST1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7051861
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CHST1, Polyclonal Antibody

★Popular Item★
 Also Known As   

CHST1 Antibody

 Product Synonym Names    Carbohydrate sulfotransferase 1; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1; GST-1; Keratan sulfate Gal-6 sulfotransferase; KS6ST; KSGal6ST; KSST; CHST1
 Product Gene Name   

anti-CHST1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AB003791 mRNA
 3D Structure    ModBase 3D Structure for O43916
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Carbohydrate sulfotransferase 1 protein (305-397AA)
 Conjugation    Non-conjugated
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CHST1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CHST1 antibody

   Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation.
 Applications Tested/Suitable for anti-CHST1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CHST1 antibody    WB: 1:500-1:5000
IHC: 1:20-1:200
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 Western Blot (WB) of anti-CHST1 antibody    Western Blot
Positive WB detected in: HL-60 whole cell lysate,Mouse brain tissue,Rat heart tissue
All lanes: CHST1 antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 47 KDa
Observed band size: 47 KDa

anti-CHST1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CHST1 antibody    Immunohistochemistry of paraffin-embedded human brain tissue using MBS7051861 at dilution of 1:100
anti-CHST1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CHST1. It may not necessarily be applicable to this product.
 NCBI GI #    4502841
 NCBI GeneID    8534
 NCBI Accession #    NP_003645.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003654.5 [Other Products]
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 UniProt Primary Accession #    O43916 [Other Products]
 UniProt Secondary Accession #    D3DQP2 [Other Products]
 UniProt Related Accession #    O43916 [Other Products]
 Molecular Weight    46,715 Da
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 NCBI Official Full Name    carbohydrate sulfotransferase 1
 NCBI Official Synonym Full Names    carbohydrate sulfotransferase 1
 NCBI Official Symbol    CHST1 [Similar Products]
 NCBI Official Synonym Symbols   
C6ST; KSST; GST-1; KS6ST; KSGal6ST
[Similar Products]
 NCBI Protein Information    carbohydrate sulfotransferase 1
 UniProt Protein Name    Carbohydrate sulfotransferase 1
 UniProt Synonym Protein Names   
Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1; GST-1; Keratan sulfate Gal-6 sulfotransferase; KS6ST; KSGal6ST; KSST
 Protein Family    Carbohydrate sulfotransferase
 UniProt Gene Name    CHST1 [Similar Products]
 UniProt Synonym Gene Names    GST-1; KS6ST; KSGal6ST; KSST [Similar Products]
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 NCBI Summary for CHST1    This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin. [provided by RefSeq, Aug 2011]
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 UniProt Comments for CHST1    CHST1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N- acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.

Protein type: EC 2.8.2.21; Glycan Metabolism - keratan sulfate biosynthesis; Membrane protein, integral; Transferase

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: Golgi membrane

Molecular Function: keratan sulfotransferase activity; N-acetylglucosamine 6-O-sulfotransferase activity; sulfotransferase activity

Biological Process: galactose metabolic process; keratan sulfate biosynthetic process; keratan sulfate metabolic process; polysaccharide metabolic process; sulfur metabolic process
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 Research Articles on CHST1    1. found endogenous expression of the long form of the enzyme in human tissue, predominantly in the trans-Golgi network of endothelial cells that form human high endothelial venules.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CHST1 antibodyDiseases associated with anti-CHST1 antibody
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Glycosaminoglycan Biosynthesis - Keratan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Keratan Sulfate Pathway Diagram
 Glycosaminoglycan Biosynthesis - Keratan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Keratan Sulfate Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Keratan Sulfate Biosynthesis Pathway antibodies  Keratan Sulfate Biosynthesis Pathway Diagram
 Keratan Sulfate/keratin Metabolism Pathway antibodies  Keratan Sulfate/keratin Metabolism Pathway Diagram
 MPS I - Hurler Syndrome Pathway antibodies  MPS I - Hurler Syndrome Pathway Diagram
 MPS II - Hunter Syndrome Pathway antibodies  MPS II - Hunter Syndrome Pathway Diagram
 MPS IIIA - Sanfilippo Syndrome A Pathway antibodies  MPS IIIA - Sanfilippo Syndrome A Pathway Diagram
 MPS IIIB - Sanfilippo Syndrome B Pathway antibodies  MPS IIIB - Sanfilippo Syndrome B Pathway Diagram
 Disease Name  Pubmed Publications
 Drug Toxicity Antibodies  >2 publications with CHST1 and Drug Toxicity
 Inflammation Antibodies  >2 publications with CHST1 and Inflammation
Organs/Tissues associated with anti-CHST1 antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with CHST1 and Eye
 Lung Antibodies  >1 publications with CHST1 and Lung
 Brain Antibodies  >1 publications with CHST1 and Brain
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