NP_003604.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
132,565 Da
NCBI Official Full Name
cartilage intermediate layer protein
NCBI Official Synonym Full Names
cartilage intermediate layer protein
NCBI Protein Information
cartilage intermediate layer protein 1
UniProt Protein Name
Cartilage intermediate layer protein 1
UniProt Synonym Protein Names
Cartilage intermediate-layer protein
UniProt Synonym Gene Names
UniProt Entry Name
CILP1_HUMAN
NCBI Summary for CILP
Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010]
UniProt Comments for CILP
CILP: Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. Defects in CILP are a cause of susceptibility to intervertebral disk disease (IDD). A common musculo- skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. Susceptibility to intervertebral disk disease, is conferred by variant p.Ile395Thr (PubMed:15864306).
Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 15q22
Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix
Molecular Function: alkaline phosphatase activity; nucleotide diphosphatase activity
Biological Process: negative regulation of insulin-like growth factor receptor signaling pathway
Disease: Intervertebral Disc Disease
Research Articles on CILP
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Products associated with anti-CILP antibody
Diseases associated with anti-CILP antibody
Organs/Tissues associated with anti-CILP antibody
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