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anti-CISD2 antibody :: Rabbit anti-Human CISD2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7003489
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CISD2, Polyclonal Antibody

★Popular Item★
 Also Known As   

CISD2 Antibody

 Product Synonym Names    CDGSH iron-sulfur domain-containing protein 2; Endoplasmic reticulum intermembrane small protein; MitoNEET-related 1 protein; Miner1; Nutrient-deprivation autophagy factor-1; NAF-1; CISD2; CDGSH2; ERIS; ZCD2
 Product Gene Name   

anti-CISD2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604928
 3D Structure    ModBase 3D Structure for Q8N5K1
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%,Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human CDGSH iron-sulfur domain-containing protein 2 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CISD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CISD2 antibody

   Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.
 Applications Tested/Suitable for anti-CISD2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

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 Immunohistochemistry (IHC) of anti-CISD2 antibody    Immunohistochemistry of paraffin-embedded human pancreatic tissue using MBS7003489 at dilution of 1:100
anti-CISD2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CISD2 antibody    Immunohistochemistry of paraffin-embedded human small intestine tissue using MBS7003489 at dilution of 1:100
anti-CISD2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CISD2 antibody    Immunofluorescent analysis of Hela cells using MBS7003489 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-CISD2 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-CISD2 antibody    Western Blot
Positive WB detected in:Hela whole cell lysate,HepG2 whole cell lysate,Mouse spleen tissue,Mouse lung tissue,Mouse kidney tissue,Mouse brain tissue
All lanes: CISD2 antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 16 kDa
Observed band size: 16 kDa

anti-CISD2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CISD2. It may not necessarily be applicable to this product.
 NCBI GI #    56605994
 NCBI GeneID    493856
 NCBI Accession #    NP_001008389.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001008388.4 [Other Products]
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 UniProt Primary Accession #    Q8N5K1 [Other Products]
 UniProt Secondary Accession #    Q7Z3D5 [Other Products]
 UniProt Related Accession #    Q8N5K1 [Other Products]
 Molecular Weight    15,278 Da
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 NCBI Official Full Name    CDGSH iron-sulfur domain-containing protein 2
 NCBI Official Synonym Full Names    CDGSH iron sulfur domain 2
 NCBI Official Symbol    CISD2 [Similar Products]
 NCBI Official Synonym Symbols   
ERIS; WFS2; ZCD2; NAF-1; Miner1
[Similar Products]
 NCBI Protein Information    CDGSH iron-sulfur domain-containing protein 2
 UniProt Protein Name    CDGSH iron-sulfur domain-containing protein 2
 UniProt Synonym Protein Names   
Endoplasmic reticulum intermembrane small protein; MitoNEET-related 1 protein; Miner1; Nutrient-deprivation autophagy factor-1; NAF-1
 Protein Family    CDGSH iron-sulfur domain-containing protein
 UniProt Gene Name    CISD2 [Similar Products]
 UniProt Synonym Gene Names    CDGSH2; ERIS; ZCD2; Miner1; NAF-1 [Similar Products]
 UniProt Entry Name    CISD2_HUMAN
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 NCBI Summary for CISD2    The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]
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 UniProt Comments for CISD2    CISD2: a single-pass membrane protein of the endoplasmic reticulum that regulates autophagy. Has also been reported to localize to the mitochondrion outer membrane. Antagonizes ATG6-mediated cellular autophagy. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca2+ stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy. Directly interacts with BCL2; the interaction is disrupted by BIK interaction with BCL2. It has been reported to mainly localizes to the mitochondrion outer membrane. Defects in CISD2 are the cause of Wolfram syndrome 2 (WFS2), is a rare autosomal recessive disorder characterized by optic atrophy and diabetes mellitus. Other symptoms include the presence of profound upper gastrointestinal ulceration, significant bleeding tendency, defective platelet aggregation with collagen and various neurological symptoms. Initially thought to be a zinc-finger protein, it was later shown to bind 1 2Fe-2S cluster instead.

Protein type: Endoplasmic reticulum; Autophagy; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; membrane; mitochondrial outer membrane; protein complex

Molecular Function: 2 iron, 2 sulfur cluster binding; metal ion binding; protein binding; protein homodimerization activity

Biological Process: mitochondrion degradation; multicellular organismal aging; regulation of autophagy

Disease: Wolfram Syndrome 2
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 Research Articles on CISD2    1. A novel CISD2 mutation is associated with wolfram syndrome 2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CISD2 antibodyDiseases associated with anti-CISD2 antibody
 Reference Product  PubMed Publications
 WFS1 antibody  >4 publications with CISD2 and WFS1
 BCL2 antibody  >3 publications with CISD2 and BCL2
 Disease Name  Pubmed Publications
 Wolfram Syndrome 2 Antibodies  >12 publications with CISD2 and Wolfram Syndrome 2
 Atrophy Antibodies  >7 publications with CISD2 and Atrophy
 Kidney Diseases Antibodies  >6 publications with CISD2 and Kidney Diseases
 Abnormalities, Multiple Antibodies  >6 publications with CISD2 and Abnormalities, Multiple
 Breast Neoplasms Antibodies  >2 publications with CISD2 and Breast Neoplasms
 Glucose Intolerance Antibodies  >1 publications with CISD2 and Glucose Intolerance
 Hyperglycemia Antibodies  >1 publications with CISD2 and Hyperglycemia
 Immune System Diseases Antibodies  >1 publications with CISD2 and Immune System Diseases
 Inflammation Antibodies  >1 publications with CISD2 and Inflammation
Organs/Tissues associated with anti-CISD2 antibody
 Organ/Tissue Name  Pubmed Publications
 Uncharacterized Tissue Antibodies  >2 publications with CISD2 and Uncharacterized Tissue
 Brain Antibodies  >2 publications with CISD2 and Brain
 Skin Antibodies  >1 publications with CISD2 and Skin
 Liver Antibodies  >1 publications with CISD2 and Liver
 Pancreas Antibodies  >1 publications with CISD2 and Pancreas
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