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anti-CITED2 antibody :: Goat CITED2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420896 anti-CITED2 antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CITED2, Polyclonal Antibody

 Also Known As   

Goat anti-CITED2 (Internal) Antibody

 Product Synonym Names    Goat Anti-CITED2 (C Terminus) Antibody; CITED2; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; HGNC: 1987; MRG1; P35SRJ; CITED2 antibody; Cbp/p300-interacting transactivator; with Glu/Asp-rich carboxy-terminal domain; 2 antibody; HGNC: 1987 antibody; MRG1 antibody; P35SRJ antibody; CITED2 (Internal)
 Product Gene Name   

anti-CITED2 antibody

[Similar Products]
 Antibody/Peptide Pairs    CITED2 peptide (MBS426344) is used for blocking the activity of CITED2 antibody (MBS420896)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    PNVIDTDFID EE
 OMIM    602937
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-PNVIDTDFIDEE, from the internal region of the protein sequence according to NP_006070.2.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-CITED2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CITED2 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-CITED2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Preliminary experiments in adult human heart, kidney, liver and skin lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
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NCBI/Uniprot data below describe general gene information for CITED2. It may not necessarily be applicable to this product.
 NCBI GI #    19923343
 NCBI GeneID    10370
 NCBI Accession #    NP_006070.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006079.4 [Other Products]
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 UniProt Secondary Accession #    O95426; Q5VTF4 [Other Products]
 UniProt Related Accession #    Q99967 [Other Products]
 Molecular Weight    23,732 Da
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 NCBI Official Full Name    cbp/p300-interacting transactivator 2 isoform 1
 NCBI Official Synonym Full Names    Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
 NCBI Official Symbol    CITED2 [Similar Products]
 NCBI Official Synonym Symbols   
ASD8; MRG1; VSD2; MRG-1; P35SRJ
[Similar Products]
 NCBI Protein Information    cbp/p300-interacting transactivator 2
 UniProt Protein Name    Cbp/p300-interacting transactivator 2
 UniProt Synonym Protein Names   
MSG-related protein 1; MRG-1; P35srj
 Protein Family    Cbp/p300-interacting transactivator
 UniProt Gene Name    CITED2 [Similar Products]
 UniProt Synonym Gene Names    MRG1; MRG-1 [Similar Products]
 UniProt Entry Name    CITE2_HUMAN
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 NCBI Summary for CITED2    The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of hypoxia-inducible factor 1-alpha to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
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 UniProt Comments for CITED2    CITED2: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator- activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left- right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. Defects in CITED2 are a cause of ventricular septal defect type 2 (VSD2). VSD2 is a common form of congenital cardiovascular anomaly that may occur alone or in combination with other cardiac malformations. It can affect any portion of the ventricular septum, resulting in abnormal communications between the two lower chambers of the heart. Classification is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect. Large defects that go unrepaired may give rise to cardiac enlargement, congestive heart failure, pulmonary hypertension, Eisenmenger's syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death. Defects in CITED2 are a cause of atrial septal defect type 8 (ASD8). ASD8 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. Belongs to the CITED family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cell cycle regulation; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: nuclear chromatin; nucleus

Molecular Function: chromatin binding; histone acetyltransferase binding; LBD domain binding; protein binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity

Biological Process: cell proliferation; determination of left/right symmetry; heart development; liver development; negative regulation of apoptosis; negative regulation of cell migration; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of cell cycle; positive regulation of cell-cell adhesion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; response to estrogen stimulus; response to hypoxia; sex determination; spleen development

Disease: Atrial Septal Defect 8; Ventricular Septal Defect 2
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 Research Articles on CITED2    1. FBXL5-mediated degradation of CITED2 leads to the activation of HIF-1 alpha.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CITED2 antibodyPathways associated with anti-CITED2 antibody
 Reference Product  PubMed Publications
 HIF1A antibody  >30 publications with CITED2 and HIF1A
 EP300 antibody  >11 publications with CITED2 and EP300
 CREBBP antibody  >7 publications with CITED2 and CREBBP
 ELK1 antibody  >1 publications with CITED2 and ELK1
 APOA1 antibody  >1 publications with CITED2 and APOA1
 Products by Pathway  Pathway Diagram
 Cellular Response To Hypoxia Pathway antibodies  Cellular Response To Hypoxia Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 HIF-2-alpha Transcription Factor Network Pathway antibodies  HIF-2-alpha Transcription Factor Network Pathway Diagram
 Regulation Of Hypoxia-inducible Factor (HIF) By Oxygen Pathway antibodies  Regulation Of Hypoxia-inducible Factor (HIF) By Oxygen Pathway Diagram
 Regulation Of Gene Expression By Hypoxia-inducible Factor Pathway antibodies  Regulation Of Gene Expression By Hypoxia-inducible Factor Pathway Diagram
Diseases associated with anti-CITED2 antibodyOrgans/Tissues associated with anti-CITED2 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >24 publications with CITED2 and Cardiovascular Diseases
 Heart Diseases Antibodies  >23 publications with CITED2 and Heart Diseases
 Disease Models, Animal Antibodies  >9 publications with CITED2 and Disease Models, Animal
 Heart Septal Defects Antibodies  >9 publications with CITED2 and Heart Septal Defects
 Liver Neoplasms Antibodies  >8 publications with CITED2 and Liver Neoplasms
 Breast Neoplasms Antibodies  >8 publications with CITED2 and Breast Neoplasms
 Inflammation Antibodies  >6 publications with CITED2 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >6 publications with CITED2 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >5 publications with CITED2 and Liver Diseases
 Neoplasms, Experimental Antibodies  >4 publications with CITED2 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >37 publications with CITED2 and Heart
 Blood Antibodies  >21 publications with CITED2 and Blood
 Vascular Antibodies  >19 publications with CITED2 and Vascular
 Muscle Antibodies  >17 publications with CITED2 and Muscle
 Liver Antibodies  >16 publications with CITED2 and Liver
 Bone Antibodies  >15 publications with CITED2 and Bone
 Embryonic Tissue Antibodies  >15 publications with CITED2 and Embryonic Tissue
 Brain Antibodies  >10 publications with CITED2 and Brain
 Kidney Antibodies  >10 publications with CITED2 and Kidney
 Lung Antibodies  >7 publications with CITED2 and Lung
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