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anti-CLASP2 antibody :: Rabbit CLASP2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS128601
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CLASP2, Polyclonal Antibody

★Popular Item★
 Also Known As   

CLASP2 Polyclonal Antibody

 Product Gene Name   

anti-CLASP2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605853
 3D Structure    ModBase 3D Structure for O75122
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Store at -20 degree C. Avoid freeze / thaw cycles.
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human CLASP2
 Calculated Molecular Weight    141kDa
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-CLASP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CLASP2 antibody    Polyclonal
 Applications Tested/Suitable for anti-CLASP2 antibody   

Western Blot (WB)

 Application Notes for anti-CLASP2 antibody    WB: 1:500-1:2000
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 Western Blot (WB) of anti-CLASP2 antibody    Western blot analysis of extracts of various cell lines, using CLASP2 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 30s.
anti-CLASP2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CLASP2. It may not necessarily be applicable to this product.
 NCBI GI #    77416392
 NCBI GeneID    23122
 NCBI Accession #    O75122.2 [Other Products]
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 UniProt Primary Accession #    O75122 [Other Products]
 UniProt Secondary Accession #    Q7L8F6; Q8N6R6; Q9BQT3; Q9BQT4; Q9H7A3; Q9NSZ2; B2RTR1; F5H604 [Other Products]
 UniProt Related Accession #    O75122 [Other Products]
 Molecular Weight    141kDa
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 NCBI Official Full Name    CLIP-associating protein 2
 NCBI Official Synonym Full Names    cytoplasmic linker associated protein 2
 NCBI Official Symbol    CLASP2 [Similar Products]
 NCBI Protein Information    CLIP-associating protein 2; protein Orbit homolog 2; multiple asters (Mast)-like homolog 2; cytoplasmic linker-associated protein 2
 UniProt Protein Name    CLIP-associating protein 2
 UniProt Synonym Protein Names   
Cytoplasmic linker-associated protein 2; Protein Orbit homolog 2; hOrbit2
 Protein Family    CLIP-associating protein
 UniProt Gene Name    CLASP2 [Similar Products]
 UniProt Synonym Gene Names    KIAA0627; hOrbit2 [Similar Products]
 UniProt Entry Name    CLAP2_HUMAN
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 UniProt Comments for CLASP2    CLASP2: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. Belongs to the CLASP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 3p22.3

Cellular Component: kinetochore microtubule; Golgi apparatus; microtubule; membrane; cytoplasmic microtubule; cytoplasm; plasma membrane; microtubule organizing center; cell cortex; trans-Golgi network; cytosol

Molecular Function: microtubule plus-end binding; protein binding; galactoside 2-alpha-L-fucosyltransferase activity

Biological Process: mitosis; microtubule organizing center organization and biogenesis; axon guidance; regulation of microtubule-based process; cell division; negative regulation of microtubule depolymerization; establishment and/or maintenance of cell polarity; mitotic cell cycle; microtubule nucleation; regulation of microtubule polymerization or depolymerization
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 Research Articles on CLASP2    1. GSK3B-dependent phosphorylation and the level of CLASP2 play a role in the maintenance of acetylcholine receptor cluster size through the regulated capture and release of microtubule plus-ends.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CLASP2 antibodyPathways associated with anti-CLASP2 antibody
 Reference Product  PubMed Publications
 CKAP5 antibody  >1 publications with CLASP2 and CKAP5
 MAPRE1 antibody  >1 publications with CLASP2 and MAPRE1
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
 Mitotic Metaphase And Anaphase Pathway antibodies  Mitotic Metaphase And Anaphase Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 Resolution Of Sister Chromatid Cohesion Pathway antibodies  Resolution Of Sister Chromatid Cohesion Pathway Diagram
 Role Of Abl In Robo-Slit Signaling Pathway antibodies  Role Of Abl In Robo-Slit Signaling Pathway Diagram
Diseases associated with anti-CLASP2 antibodyOrgans/Tissues associated with anti-CLASP2 antibody
 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >2 publications with CLASP2 and Chromosome Aberrations
 Breast Neoplasms Antibodies  >1 publications with CLASP2 and Breast Neoplasms
 Brain Diseases Antibodies  >1 publications with CLASP2 and Brain Diseases
 Congenital Abnormalities Antibodies  >1 publications with CLASP2 and Congenital Abnormalities
 Abnormalities, Multiple Antibodies  >1 publications with CLASP2 and Abnormalities, Multiple
 Neurobehavioral Manifestations Antibodies  >1 publications with CLASP2 and Neurobehavioral Manifestations
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >7 publications with CLASP2 and Nerve
 Brain Antibodies  >6 publications with CLASP2 and Brain
 Muscle Antibodies  >3 publications with CLASP2 and Muscle
 Spinal Cord Antibodies  >3 publications with CLASP2 and Spinal Cord
 Eye Antibodies  >2 publications with CLASP2 and Eye
 Blood Antibodies  >2 publications with CLASP2 and Blood
 Vascular Antibodies  >1 publications with CLASP2 and Vascular
 Heart Antibodies  >1 publications with CLASP2 and Heart
 Lung Antibodies  >1 publications with CLASP2 and Lung
 Ear Antibodies  >1 publications with CLASP2 and Ear
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