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anti-CLASP2 antibody :: Rabbit anti-Human CLASP2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7002720
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CLASP2, Polyclonal Antibody

★Popular Item★
 Also Known As   

CLASP2 Antibody

 Product Synonym Names    CLIP-associating protein 2; CLASP2; KIAA0627; Cytoplasmic linker-associated protein 2; Protein Orbit homolog 2; hOrbit2
 Product Gene Name   

anti-CLASP2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605853
 3D Structure    ModBase 3D Structure for O75122
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Affinity Purified
 Form/Format    Liquid
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 Immunogen    Recombinant human CLIP-associating protein 2 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-102447 / sc-102445 / sc-98440
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CLASP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CLASP2 antibody

   Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
 Applications Tested/Suitable for anti-CLASP2 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-CLASP2 antibody    Recommended dilution: IHC: 1:20-1:200
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 Immunohistochemistry (IHC) of anti-CLASP2 antibody    Immunohistochemistry of paraffin-embedded human liver cancer tissue using MBS7002720 at dilution 1:100
anti-CLASP2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CLASP2. It may not necessarily be applicable to this product.
 NCBI GI #    333440451
 NCBI GeneID    23122
 NCBI Accession #    NP_001193973.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001207044.1 [Other Products]
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 UniProt Primary Accession #    O75122 [Other Products]
 UniProt Secondary Accession #    Q7L8F6; Q8N6R6; Q9BQT3; Q9BQT4; Q9H7A3; Q9NSZ2; B2RTR1; F5H604 [Other Products]
 UniProt Related Accession #    O75122 [Other Products]
 Molecular Weight    165,924 Da
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 NCBI Official Full Name    CLIP-associating protein 2 isoform 2
 NCBI Official Synonym Full Names    cytoplasmic linker associated protein 2
 NCBI Official Symbol    CLASP2 [Similar Products]
 NCBI Protein Information    CLIP-associating protein 2
 UniProt Protein Name    CLIP-associating protein 2
 UniProt Synonym Protein Names   
Cytoplasmic linker-associated protein 2; Protein Orbit homolog 2; hOrbit2
 Protein Family    CLIP-associating protein
 UniProt Gene Name    CLASP2 [Similar Products]
 UniProt Synonym Gene Names    KIAA0627; hOrbit2 [Similar Products]
 UniProt Entry Name    CLAP2_HUMAN
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 UniProt Comments for CLASP2    CLASP2: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. Belongs to the CLASP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p22.3

Cellular Component: basal cortex; cell cortex; cytoplasm; cytoplasmic microtubule; cytosol; focal adhesion; Golgi apparatus; kinetochore; kinetochore microtubule; leading edge; membrane; microtubule; microtubule organizing center; plasma membrane; trans-Golgi network

Molecular Function: actin filament binding; microtubule binding; microtubule plus-end binding; protein binding

Biological Process: axon guidance; cell division; establishment and/or maintenance of cell polarity; exit from mitosis; Golgi organization and biogenesis; microtubule cytoskeleton organization and biogenesis; microtubule nucleation; microtubule organizing center organization and biogenesis; mitotic cell cycle; mitotic spindle organization and biogenesis; negative regulation of focal adhesion formation; negative regulation of microtubule depolymerization; negative regulation of stress fiber formation; positive regulation of exocytosis; regulation of actin cytoskeleton organization and biogenesis; regulation of axon extension; regulation of gastrulation; regulation of microtubule polymerization; regulation of microtubule polymerization or depolymerization; regulation of microtubule-based process; small GTPase mediated signal transduction; vesicle targeting
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 Research Articles on CLASP2    1. PAR3 and aPKC control the organization of the Golgi through CLASP2 phosphorylation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CLASP2 antibodyPathways associated with anti-CLASP2 antibody
 Reference Product  PubMed Publications
 MAPRE1 antibody  >1 publications with CLASP2 and MAPRE1
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
 Mitotic Metaphase And Anaphase Pathway antibodies  Mitotic Metaphase And Anaphase Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 RHO GTPase Effectors Pathway antibodies  RHO GTPase Effectors Pathway Diagram
 RHO GTPases Activate Formins Pathway antibodies  RHO GTPases Activate Formins Pathway Diagram
Diseases associated with anti-CLASP2 antibodyOrgans/Tissues associated with anti-CLASP2 antibody
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >2 publications with CLASP2 and Congenital Abnormalities
 Chromosome Aberrations Antibodies  >2 publications with CLASP2 and Chromosome Aberrations
 Brain Diseases Antibodies  >1 publications with CLASP2 and Brain Diseases
 Urogenital Abnormalities Antibodies  >1 publications with CLASP2 and Urogenital Abnormalities
 Abnormalities, Multiple Antibodies  >1 publications with CLASP2 and Abnormalities, Multiple
 Neurobehavioral Manifestations Antibodies  >1 publications with CLASP2 and Neurobehavioral Manifestations
 Breast Neoplasms Antibodies  >1 publications with CLASP2 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >8 publications with CLASP2 and Nerve
 Brain Antibodies  >6 publications with CLASP2 and Brain
 Muscle Antibodies  >5 publications with CLASP2 and Muscle
 Spinal Cord Antibodies  >3 publications with CLASP2 and Spinal Cord
 Vascular Antibodies  >2 publications with CLASP2 and Vascular
 Eye Antibodies  >2 publications with CLASP2 and Eye
 Blood Antibodies  >2 publications with CLASP2 and Blood
 Heart Antibodies  >1 publications with CLASP2 and Heart
 Lung Antibodies  >1 publications with CLASP2 and Lung
 Ear Antibodies  >1 publications with CLASP2 and Ear
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