NP_001193973.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
165,924 Da
NCBI Official Full Name
CLIP-associating protein 2 isoform 2
NCBI Official Synonym Full Names
cytoplasmic linker associated protein 2
NCBI Protein Information
CLIP-associating protein 2
UniProt Protein Name
CLIP-associating protein 2
UniProt Synonym Protein Names
Cytoplasmic linker-associated protein 2; Protein Orbit homolog 2; hOrbit2
UniProt Synonym Gene Names
UniProt Entry Name
CLAP2_HUMAN
UniProt Comments for CLASP2
CLASP2: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. Belongs to the CLASP family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p22.3
Cellular Component: basal cortex; cell cortex; cytoplasm; cytoplasmic microtubule; cytosol; focal adhesion; Golgi apparatus; kinetochore; kinetochore microtubule; leading edge; membrane; microtubule; microtubule organizing center; plasma membrane; trans-Golgi network
Molecular Function: actin filament binding; microtubule binding; microtubule plus-end binding; protein binding
Biological Process: axon guidance; cell division; establishment and/or maintenance of cell polarity; exit from mitosis; Golgi organization and biogenesis; microtubule cytoskeleton organization and biogenesis; microtubule nucleation; microtubule organizing center organization and biogenesis; mitotic cell cycle; mitotic spindle organization and biogenesis; negative regulation of focal adhesion formation; negative regulation of microtubule depolymerization; negative regulation of stress fiber formation; positive regulation of exocytosis; regulation of actin cytoskeleton organization and biogenesis; regulation of axon extension; regulation of gastrulation; regulation of microtubule polymerization; regulation of microtubule polymerization or depolymerization; regulation of microtubule-based process; small GTPase mediated signal transduction; vesicle targeting
Research Articles on CLASP2
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Products associated with anti-CLASP2 antibody
Pathways associated with anti-CLASP2 antibody
Diseases associated with anti-CLASP2 antibody
Organs/Tissues associated with anti-CLASP2 antibody
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