Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow CLCF1 rightarrow Polyclonal CLCF1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • CD28 Antibody
 • PPARG cDNA Clone
 • Rheumatoid Factor IgG (RFIgG) ELISA Kit
 • Glutathione S-Transferase Omega 1 140 D (GST-01) Recombinant Protein
 • Pyruvate kinase isozymes M1-M2 (PKM2) Recombinant Protein
 • MT ELISA Kit
 • SERPINB12 Antibody
 • 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) ELISA Kit
 • COX1 Antibody
 • Acetylcholine (ACH) ELISA Kit
 • 5'-AMP-activated protein kinase catalytic subunit alpha-1 (P... Recombinant Protein
 • IL-10 (IL10) ELISA Kit
 • CDC6 Antibody
 • Interleukin 33 (IL-33) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-CLCF1 antibody :: Rabbit CLCF1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9206438
Western Blot (WB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CLCF1, Polyclonal Antibody

 Also Known As   

CLCF1 Antibody (N-term)

 Product Synonym Names    Cardiotrophin-like cytokine factor 1; B-cell-stimulating factor 3; BSF-3; Novel neurotrophin-1; NNT-1; CLCF1; BSF3; CLC; NNT1
 Product Gene Name   

anti-CLCF1 antibody

[Similar Products]
 Antibody/Peptide Pairs    CLCF1 peptide (MBS9223749) is used for blocking the activity of CLCF1 antibody (MBS9206438)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Immunogen Sequence Positions    46-72
 OMIM    607672
 3D Structure    ModBase 3D Structure for Q9UBD9
Section Bar
 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human (Predicted Reactivity: Mouse)
Section Bar
 Specificity    This CLCF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of human CLCF1.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.5 (lot specific)
Section Bar
 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
Section Bar
 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-CLCF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-CLCF1 antibody

   This gene is a member of the glycoprotein (gp)130 cytokine
family and encodes cardiotrophin-like cytokine factor 1 (CLCF1).
CLCF1 forms a heterodimer complex with cytokine receptor-like
factor 1 (CRLF1). This dimer competes with ciliary neurotrophic
factor (CNTF) for binding to the ciliary neurotrophic factor
receptor (CNTFR) complex, and activates the Jak-STAT signaling
cascade. CLCF1 can be actively secreted from cells by forming a
complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a
potent neurotrophic factor, B-cell stimulatory agent and
neuroendocrine modulator of pituitary corticotroph function.
Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2).
This syndrome is characterized by a profuse sweating after exposure
to cold as well as congenital physical abnormalities of the head
and spine. Alternative splicing results in multiple transcript
variants encoding distinct isoforms.
 Product Categories/Family for anti-CLCF1 antibody    Immunology
 Applications Tested/Suitable for anti-CLCF1 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CLCF1 antibody    WB~~1:1000
Section Bar
 Western Blot (WB) of anti-CLCF1 antibody    CLCF1 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the CLCF1 antibody detected the CLCF1 protein (arrow).
anti-CLCF1 antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CLCF1. It may not necessarily be applicable to this product.
 NCBI GI #    261245022
 NCBI GeneID    23529
 NCBI Accession #    NP_001159684.1 [Other Products]
 NCBI Related Accession #    NP_037378.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001166212.1 [Other Products]
Section Bar
 UniProt Primary Accession #    Q9UBD9 [Other Products]
 UniProt Secondary Accession #    Q6NZA4; B4DNT4 [Other Products]
 UniProt Related Accession #    Q9UBD9 [Other Products]
 Molecular Weight    25176
Table BarTOPTable Bar
 NCBI Official Full Name    cardiotrophin-like cytokine factor 1 isoform 2
 NCBI Official Synonym Full Names    cardiotrophin-like cytokine factor 1
 NCBI Official Symbol    CLCF1 [Similar Products]
 NCBI Official Synonym Symbols   
CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1
[Similar Products]
 NCBI Protein Information    cardiotrophin-like cytokine factor 1
 UniProt Protein Name    Cardiotrophin-like cytokine factor 1
 UniProt Synonym Protein Names   
B-cell-stimulating factor 3; BSF-3; Novel neurotrophin-1; NNT-1
 Protein Family    Cardiotrophin-like cytokine factor
 UniProt Gene Name    CLCF1 [Similar Products]
 UniProt Synonym Gene Names    BSF3; CLC; NNT1; BSF-3; NNT-1 [Similar Products]
 UniProt Entry Name    CLCF1_HUMAN
Section Bar
 NCBI Summary for CLCF1    This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Section Bar
 UniProt Comments for CLCF1    CLCF1: Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor. Defects in CLCF1 are the cause of cold-induced sweating syndrome type 2 (CISS2). Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high- arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Cytokine; Apoptosis

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: extracellular region

Molecular Function: protein binding; growth factor activity; protein heterodimerization activity; cytokine activity; ciliary neurotrophic factor receptor binding; receptor binding

Biological Process: positive regulation of immunoglobulin production; cell surface receptor linked signal transduction; B cell differentiation; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; positive regulation of B cell proliferation; negative regulation of neuron apoptosis; JAK-STAT cascade; positive regulation of isotype switching to IgE isotypes; positive regulation of astrocyte differentiation; positive regulation of tyrosine phosphorylation of Stat3 protein

Disease: Cold-induced Sweating Syndrome 2
Table BarTOPTable Bar
 

Product References and Citations for anti-CLCF1 antibody

   Rousseau, F., et al. J. Biol. Chem. 283(44):30341-30350(2008)
Dagoneau, N., et al. Am. J. Hum. Genet. 80(5):966-970(2007)
Rousseau, F., et al. Proc. Natl. Acad. Sci. U.S.A. 103(26):10068-10073(2006)
Perret, D., et al. J. Biol. Chem. 279(42):43961-43970(2004)
Burger, R., et al. Br. J. Haematol. 123(5):869-878(2003)
Section Bar
 Research Articles on CLCF1    1. Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-CLCF1 antibodyPathways associated with anti-CLCF1 antibody
 Reference Product  PubMed Publications
 CRLF1 antibody  >10 publications with CLCF1 and CRLF1
 CNTFR antibody  >2 publications with CLCF1 and CNTFR
 PARK7 antibody  >1 publications with CLCF1 and PARK7
 Products by Pathway  Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
Diseases associated with anti-CLCF1 antibodyOrgans/Tissues associated with anti-CLCF1 antibody
 Disease Name  Pubmed Publications
 Seizures Antibodies  >2 publications with CLCF1 and Seizures
 Cardiovascular Diseases Antibodies  >2 publications with CLCF1 and Cardiovascular Diseases
 Inflammation Antibodies  >2 publications with CLCF1 and Inflammation
 Congenital Abnormalities Antibodies  >1 publications with CLCF1 and Congenital Abnormalities
 Lung Neoplasms Antibodies  >1 publications with CLCF1 and Lung Neoplasms
 Lung Diseases Antibodies  >1 publications with CLCF1 and Lung Diseases
 Necrosis Antibodies  >1 publications with CLCF1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >5 publications with CLCF1 and Nerve
 Brain Antibodies  >3 publications with CLCF1 and Brain
 Skin Antibodies  >3 publications with CLCF1 and Skin
 Liver Antibodies  >1 publications with CLCF1 and Liver
 Bone Marrow Antibodies  >1 publications with CLCF1 and Bone Marrow
 Bone Antibodies  >1 publications with CLCF1 and Bone
 Lung Antibodies  >1 publications with CLCF1 and Lung
 Kidney Antibodies  >1 publications with CLCF1 and Kidney
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions