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anti-CLCNKA antibody :: Rabbit CLCNKA Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS129305
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CLCNKA, Polyclonal Antibody

★Popular Item★
 Also Known As   

CLCNKA Polyclonal Antibody

 Product Synonym Names    CLCK1; ClC-K1; hClC-Ka
 Product Gene Name   

anti-CLCNKA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 613090
 3D Structure    ModBase 3D Structure for P51800
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human CLCNKA
 Calculated Molecular Weight    75kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-CLCNKA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CLCNKA antibody

   This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
 Product Categories/Family for anti-CLCNKA antibody    Polyclonal
 Applications Tested/Suitable for anti-CLCNKA antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CLCNKA antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-CLCNKA antibody    Western blot analysis of extracts of various cell lines, using CLCNKA Antibody at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Exposure time: 90s.
anti-CLCNKA antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CLCNKA. It may not necessarily be applicable to this product.
 NCBI GI #    1705857
 NCBI GeneID    1187
 NCBI Accession #    P51800.1 [Other Products]
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 UniProt Primary Accession #    P51800 [Other Products]
 UniProt Secondary Accession #    Q5T5P8; Q5T5Q4; Q7Z6D1; Q86VT1; B4DPD3; E7EPH6 [Other Products]
 UniProt Related Accession #    P51800 [Other Products]
 Molecular Weight    687
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 NCBI Official Full Name    Chloride channel protein ClC-Ka
 NCBI Official Synonym Full Names    chloride channel, voltage-sensitive Ka
 NCBI Official Symbol    CLCNKA [Similar Products]
 NCBI Official Synonym Symbols   
CLCK1; ClC-K1; hClC-Ka
[Similar Products]
 NCBI Protein Information    chloride channel protein ClC-Ka; chloride channel Ka; chloride channel, kidney, A
 UniProt Protein Name    Chloride channel protein ClC-Ka
 UniProt Synonym Protein Names   
ClC-K1
 Protein Family    Chloride channel protein
 UniProt Gene Name    CLCNKA [Similar Products]
 UniProt Synonym Gene Names    Chloride channel Ka [Similar Products]
 UniProt Entry Name    CLCKA_HUMAN
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 NCBI Summary for CLCNKA    This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CLCNKA    CLCNKA: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. Defects in CLCNKA are a cause of Bartter syndrome type 4B (BS4B). A digenic, recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. Bartter syndrome type 4B is associated with sensorineural deafness. Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily.

Protein type: Transporter, ion channel; Membrane protein, integral; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: metal ion binding; voltage-gated chloride channel activity

Biological Process: transport; excretion; transmembrane transport

Disease: Bartter Syndrome, Type 4b
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 Research Articles on CLCNKA    1. HEK293 cells the potentiating effect of niflumic acid (NFA) on CLC-Ka/barttin and CLC-Kb/barttin channels seems to be absent while the blocking efficacy of niflumic acid and benzofuran derivatives observed in oocytes is preserved
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CLCNKA antibodyPathways associated with anti-CLCNKA antibody
 Reference Product  PubMed Publications
 BSND antibody  >19 publications with CLCNKA and BSND
 AQP2 antibody  >3 publications with CLCNKA and AQP2
 AVPR2 antibody  >2 publications with CLCNKA and AVPR2
 KCNJ1 antibody  >2 publications with CLCNKA and KCNJ1
 SLC12A1 antibody  >2 publications with CLCNKA and SLC12A1
 MAZ antibody  >2 publications with CLCNKA and MAZ
 KLF15 antibody  >2 publications with CLCNKA and KLF15
 SLC12A3 antibody  >1 publications with CLCNKA and SLC12A3
 Products by Pathway  Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
Diseases associated with anti-CLCNKA antibodyOrgans/Tissues associated with anti-CLCNKA antibody
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >9 publications with CLCNKA and Hypertension
 Nervous System Diseases Antibodies  >4 publications with CLCNKA and Nervous System Diseases
 Ear Diseases Antibodies  >4 publications with CLCNKA and Ear Diseases
 Liver Diseases Antibodies  >1 publications with CLCNKA and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >62 publications with CLCNKA and Kidney
 Lung Antibodies  >1 publications with CLCNKA and Lung
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