NP_612210.4
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,449 Da
NCBI Official Full Name
C-type lectin domain family 12 member A isoform 1
NCBI Official Synonym Full Names
C-type lectin domain family 12 member A
NCBI Official Synonym Symbols
CLL1; MICL; CD371; CLL-1; DCAL-2 [Similar Products]
NCBI Protein Information
C-type lectin domain family 12 member A
UniProt Protein Name
C-type lectin domain family 12 member A
UniProt Synonym Protein Names
C-type lectin-like molecule 1; CLL-1; Dendritic cell-associated lectin 2; DCAL-2; Myeloid inhibitory C-type lectin-like receptor; MICL
UniProt Synonym Gene Names
UniProt Entry Name
CL12A_HUMAN
NCBI Summary for CLEC12A
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. [provided by RefSeq, May 2011]
UniProt Comments for CLEC12A
CLEC12A: Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13.2
Cellular Component: integral to membrane; plasma membrane
Molecular Function: carbohydrate binding
Research Articles on CLEC12A
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Diseases associated with anti-CLEC12A antibody
Organs/Tissues associated with anti-CLEC12A antibody
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