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anti-CLEC4C antibody :: Rabbit anti-Human CLEC4C Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1496361
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CLEC4C, Polyclonal Antibody

★Popular Item★
 Also Known As   

CLEC4C Antibody

 Product Synonym Names    C-type lectin domain family 4 member C; CLEC4C; BDCA2; CLECSF11; CLECSF7; DLEC; HECL; UNQ9361/PRO34150; Blood dendritic cell antigen 2; BDCA-2; C-type lectin superfamily member 7; Dendritic lectin; CD_antigen: CD303
 Product Gene Name   

anti-CLEC4C antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606677
 3D Structure    ModBase 3D Structure for Q8WTT0
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Recombinant human C-type lectin domain family 4 member C protein
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CLEC4C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CLEC4C antibody

   Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.
 Applications Tested/Suitable for anti-CLEC4C antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-CLEC4C antibody    Recommended dilution: IHC:1:20-1:200
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 Immunohistochemistry (IHC) of anti-CLEC4C antibody    Immunohistochemistry of paraffin-embedded human testis using MBS1496361 at dilution of 1:100
anti-CLEC4C antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CLEC4C antibody    Immunohistochemistry of paraffin-embedded human adrenal gland tissue using MBS1496361 at dilution of 1:100
anti-CLEC4C antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CLEC4C. It may not necessarily be applicable to this product.
 NCBI GI #    18466806
 NCBI GeneID    170482
 NCBI Accession #    NP_569708.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_130441.2 [Other Products]
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 UniProt Primary Accession #    Q8WTT0 [Other Products]
 UniProt Secondary Accession #    Q3T1C3; Q6UXS8; Q8WXX8; D3DUU3 [Other Products]
 UniProt Related Accession #    Q8WTT0 [Other Products]
 Molecular Weight    21,498 Da
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 NCBI Official Full Name    C-type lectin domain family 4 member C isoform 1
 NCBI Official Synonym Full Names    C-type lectin domain family 4 member C
 NCBI Official Symbol    CLEC4C [Similar Products]
 NCBI Official Synonym Symbols   
DLEC; HECL; BDCA2; CD303; CLECSF7; CLECSF11; PRO34150
[Similar Products]
 NCBI Protein Information    C-type lectin domain family 4 member C
 UniProt Protein Name    C-type lectin domain family 4 member C
 UniProt Synonym Protein Names   
Blood dendritic cell antigen 2; BDCA-2; C-type lectin superfamily member 7; Dendritic lectin; CD_antigen: CD303
 Protein Family    C-type lectin domain family
 UniProt Gene Name    CLEC4C [Similar Products]
 UniProt Synonym Gene Names    BDCA2; CLECSF11; CLECSF7; DLEC; HECL; BDCA-2 [Similar Products]
 UniProt Entry Name    CLC4C_HUMAN
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 NCBI Summary for CLEC4C    This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CLEC4C    CLEC4C: Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein- tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 12p13.2-p12.3

Cellular Component: integral to membrane; plasma membrane

Molecular Function: carbohydrate binding

Biological Process: adaptive immune response; innate immune response; stimulatory C-type lectin receptor signaling pathway
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 Research Articles on CLEC4C    1. Human BDCA2+CD123+CD56+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CLEC4C antibodyPathways associated with anti-CLEC4C antibody
 Reference Product  PubMed Publications
 CD1C antibody  >17 publications with CLEC4C and CD1C
 IL3RA antibody  >14 publications with CLEC4C and IL3RA
 ITGAX antibody  >13 publications with CLEC4C and ITGAX
 TLR9 antibody  >11 publications with CLEC4C and TLR9
 TLR7 antibody  >10 publications with CLEC4C and TLR7
 CD83 antibody  >6 publications with CLEC4C and CD83
 Products by Pathway  Pathway Diagram
 C-type Lectin Receptors (CLRs) Pathway antibodies  C-type Lectin Receptors (CLRs) Pathway Diagram
 Dectin-2 Family Pathway antibodies  Dectin-2 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
Diseases associated with anti-CLEC4C antibodyOrgans/Tissues associated with anti-CLEC4C antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >6 publications with CLEC4C and Necrosis
 Inflammation Antibodies  >6 publications with CLEC4C and Inflammation
 Dermatitis Antibodies  >3 publications with CLEC4C and Dermatitis
 Genital Diseases, Female Antibodies  >2 publications with CLEC4C and Genital Diseases, Female
 Male Urogenital Diseases Antibodies  >2 publications with CLEC4C and Male Urogenital Diseases
 Gonadal Disorders Antibodies  >1 publications with CLEC4C and Gonadal Disorders
 Adenoma Antibodies  >1 publications with CLEC4C and Adenoma
 Cystadenoma Antibodies  >1 publications with CLEC4C and Cystadenoma
 Granuloma Antibodies  >1 publications with CLEC4C and Granuloma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >71 publications with CLEC4C and Blood
 Lung Antibodies  >3 publications with CLEC4C and Lung
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