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anti-CLEC4E antibody :: Rabbit anti-Human, Mouse CLEC4E Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1497212 anti-CLEC4E antibody
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CLEC4E, Polyclonal Antibody

★Popular Item★
 Also Known As   

CLEC4E Antibody, Biotin conjugated

 Product Synonym Names    C-type lectin domain family 4 member E; CLEC4E; CLECSF9; MINCLE; UNQ218/PRO244; C-type lectin superfamily member 9; Macrophage-inducible C-type lectin
 Product Gene Name   

anti-CLEC4E antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609962
 3D Structure    ModBase 3D Structure for Q9ULY5
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    >95%, Protein G Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Biotin
 Immunogen    Recombinant human C-type lectin domain family 4 member E protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-161488
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CLEC4E antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CLEC4E antibody

   C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
 Applications Tested/Suitable for anti-CLEC4E antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for CLEC4E. It may not necessarily be applicable to this product.
 NCBI GI #    7657333
 NCBI GeneID    26253
 NCBI Accession #    NP_055173.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_014358.3 [Other Products]
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 UniProt Primary Accession #    Q9ULY5 [Other Products]
 UniProt Secondary Accession #    B2R6Q6 [Other Products]
 UniProt Related Accession #    Q9ULY5 [Other Products]
 Molecular Weight    25,073 Da
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 NCBI Official Full Name    C-type lectin domain family 4 member E
 NCBI Official Synonym Full Names    C-type lectin domain family 4 member E
 NCBI Official Symbol    CLEC4E [Similar Products]
 NCBI Official Synonym Symbols   
MINCLE; CLECSF9
[Similar Products]
 NCBI Protein Information    C-type lectin domain family 4 member E
 UniProt Protein Name    C-type lectin domain family 4 member E
 UniProt Synonym Protein Names   
C-type lectin superfamily member 9; Macrophage-inducible C-type lectin
 Protein Family    C-type lectin domain family
 UniProt Gene Name    CLEC4E [Similar Products]
 UniProt Synonym Gene Names    CLECSF9; MINCLE [Similar Products]
 UniProt Entry Name    CLC4E_HUMAN
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 NCBI Summary for CLEC4E    This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CLEC4E    CLEC4E: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: integral to membrane; plasma membrane

Molecular Function: carbohydrate binding; receptor activity

Biological Process: defense response to bacterium; innate immune response; positive regulation of cytokine secretion; stimulatory C-type lectin receptor signaling pathway; T cell differentiation during immune response
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 Research Articles on CLEC4E    1. Data indicate that MINCLE receptor is able to mediate the response to trehalose-6,6-dimycolate (TDM) dependent on SYK kinase and CARD9 protein.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CLEC4E antibodyPathways associated with anti-CLEC4E antibody
 Reference Product  PubMed Publications
 TLR4 antibody  >2 publications with CLEC4E and TLR4
 TLR2 antibody  >2 publications with CLEC4E and TLR2
 CARD9 antibody  >2 publications with CLEC4E and CARD9
 CLEC1A antibody  >1 publications with CLEC4E and CLEC1A
 SYK antibody  >1 publications with CLEC4E and SYK
 Products by Pathway  Pathway Diagram
 C-type Lectin Receptors (CLRs) Pathway antibodies  C-type Lectin Receptors (CLRs) Pathway Diagram
 Dectin-2 Family Pathway antibodies  Dectin-2 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
Diseases associated with anti-CLEC4E antibodyOrgans/Tissues associated with anti-CLEC4E antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7 publications with CLEC4E and Inflammation
 Necrosis Antibodies  >3 publications with CLEC4E and Necrosis
 Liver Diseases Antibodies  >2 publications with CLEC4E and Liver Diseases
 Skin Diseases Antibodies  >2 publications with CLEC4E and Skin Diseases
 Disease Models, Animal Antibodies  >2 publications with CLEC4E and Disease Models, Animal
 Brain Injuries Antibodies  >2 publications with CLEC4E and Brain Injuries
 Pneumonia Antibodies  >1 publications with CLEC4E and Pneumonia
 Poisoning Antibodies  >1 publications with CLEC4E and Poisoning
 Lung Injury Antibodies  >1 publications with CLEC4E and Lung Injury
 Drug-Induced Liver Injury Antibodies  >1 publications with CLEC4E and Drug-Induced Liver Injury
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with CLEC4E and Blood
 Lung Antibodies  >3 publications with CLEC4E and Lung
 Brain Antibodies  >2 publications with CLEC4E and Brain
 Spleen Antibodies  >2 publications with CLEC4E and Spleen
 Mixed Antibodies  >1 publications with CLEC4E and Mixed
 Connective Tissue Antibodies  >1 publications with CLEC4E and Connective Tissue
 Kidney Antibodies  >1 publications with CLEC4E and Kidney
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