NP_055173.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,073 Da
NCBI Official Full Name
C-type lectin domain family 4 member E
NCBI Official Synonym Full Names
C-type lectin domain family 4, member E
NCBI Protein Information
C-type lectin domain family 4 member E; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9; C-type lectin superfamily member 9; macrophage-inducible C-type lectin
UniProt Protein Name
C-type lectin domain family 4 member E
UniProt Synonym Protein Names
C-type lectin superfamily member 9; Macrophage-inducible C-type lectin
UniProt Synonym Gene Names
UniProt Entry Name
CLC4E_HUMAN
NCBI Summary for CLEC4E
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
UniProt Comments for CLEC4E
CLEC4E: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: integral to membrane
Molecular Function: receptor activity; carbohydrate binding
Biological Process: immune response; positive regulation of cytokine secretion
Research Articles on CLEC4E
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Products associated with anti-CLEC4E antibody
Pathways associated with anti-CLEC4E antibody
Diseases associated with anti-CLEC4E antibody
Organs/Tissues associated with anti-CLEC4E antibody
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