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anti-CLEC7A antibody :: Rabbit anti-Human, Mouse CLEC7A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9414183
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CLEC7A, Polyclonal Antibody

 Also Known As   

CLEC7A Antibody

 Product Synonym Names    BGR; CANDF4; DECTIN1; CLECSF12
 Product Gene Name   

anti-CLEC7A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606264
 3D Structure    ModBase 3D Structure for Q9BXN2
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    The antibody detects endogenous levels of total CLEC7A protein.
 Purity/Purification    Antigen affinity purification.
 Form/Format    Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
 Concentration    0.2 mg/ml (lot specific)
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 Immunogen Type    Recombinant Protein
 Immunogen Description    Full length fusion protein
 Target Name    CLEC7A
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-CLEC7A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CLEC7A antibody

   This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
 Product Categories/Family for anti-CLEC7A antibody    Total protein Ab
 Applications Tested/Suitable for anti-CLEC7A antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CLEC7A antibody    Western blotting: 1:500-1:2000
Immunohistochemistry: 1:10-1:50
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 Testing Data of anti-CLEC7A antibody    Gel: 12%SDS-PAGE Lysates (from left to right): SP20 and RAW264.7 cell Amount of lysate: 40ug per lane Primary antibody: 1/200 dilution Secondary antibody dilution: 1/8000 Exposure time: 30 seconds
anti-CLEC7A antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-CLEC7A antibody    Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/5.
anti-CLEC7A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CLEC7A. It may not necessarily be applicable to this product.
 NCBI GI #    13384604
 NCBI GeneID    64581
 NCBI Accession #    NP_072092.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_022570.4 [Other Products]
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 UniProt Primary Accession #    Q9BXN2 [Other Products]
 UniProt Secondary Accession #    Q6IPS7; Q96D32; Q96DR9; Q96LD3; Q96PA4; Q96PA5; Q96PA6; B2R861; B7Z494; B7Z5A9; B7Z5B9 [Other Products]
 UniProt Related Accession #    Q9BXN2 [Other Products]
 Molecular Weight    28kd
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 NCBI Official Full Name    C-type lectin domain family 7 member A isoform b
 NCBI Official Synonym Full Names    C-type lectin domain family 7, member A
 NCBI Official Symbol    CLEC7A [Similar Products]
 NCBI Official Synonym Symbols   
BGR; CD369; CANDF4; DECTIN1; CLECSF12
[Similar Products]
 NCBI Protein Information    C-type lectin domain family 7 member A
 UniProt Protein Name    C-type lectin domain family 7 member A
 UniProt Synonym Protein Names   
Beta-glucan receptor; C-type lectin superfamily member 12; Dendritic cell-associated C-type lectin 1; DC-associated C-type lectin 1; Dectin-1
 Protein Family    C-type lectin domain family
 UniProt Gene Name    CLEC7A [Similar Products]
 UniProt Synonym Gene Names    BGR; CLECSF12; DECTIN1; DC-associated C-type lectin 1; Dectin-1 [Similar Products]
 UniProt Entry Name    CLC7A_HUMAN
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 NCBI Summary for CLEC7A    This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CLEC7A    dectin-1: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Up-regulated during differentiation from monocytes into dendritic cells. Isoform 5 interacts with RANBP9. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.2

Cellular Component: cytoplasm; plasma membrane; integral to membrane

Molecular Function: metal ion binding; MHC protein binding; carbohydrate binding; pattern recognition receptor activity

Biological Process: T cell activation; innate immune response; carbohydrate mediated signaling; cell recognition; phagocytosis, recognition; pattern recognition receptor signaling pathway; inflammatory response; defense response to protozoan

Disease: Aspergillosis, Susceptibility To; Candidiasis, Familial, 4
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 Research Articles on CLEC7A    1. The analysis of Dectin-1 gene polymorphisms showed no significant association with fungal keratitis in the northern Han Chinese population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CLEC7A antibodyPathways associated with anti-CLEC7A antibody
 Reference Product  PubMed Publications
 TLR2 antibody  >14 publications with CLEC7A and TLR2
 SYK antibody  >9 publications with CLEC7A and SYK
 SRC antibody  >2 publications with CLEC7A and SRC
 Products by Pathway  Pathway Diagram
 C-type Lectin Receptors (CLRs) Pathway antibodies  C-type Lectin Receptors (CLRs) Pathway Diagram
 CLEC7A (Dectin-1) Signaling Pathway antibodies  CLEC7A (Dectin-1) Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
Diseases associated with anti-CLEC7A antibodyOrgans/Tissues associated with anti-CLEC7A antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >14 publications with CLEC7A and Inflammation
 Necrosis Antibodies  >5 publications with CLEC7A and Necrosis
 Lung Diseases Antibodies  >4 publications with CLEC7A and Lung Diseases
 Disease Models, Animal Antibodies  >3 publications with CLEC7A and Disease Models, Animal
 Liver Diseases Antibodies  >2 publications with CLEC7A and Liver Diseases
 Atherosclerosis Antibodies  >1 publications with CLEC7A and Atherosclerosis
 Respiratory Tract Infections Antibodies  >1 publications with CLEC7A and Respiratory Tract Infections
 Cardiovascular Diseases Antibodies  >1 publications with CLEC7A and Cardiovascular Diseases
 Non-alcoholic Fatty Liver Disease Antibodies  >1 publications with CLEC7A and Non-alcoholic Fatty Liver Disease
 Fatty Liver Antibodies  >1 publications with CLEC7A and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >28 publications with CLEC7A and Blood
 Lung Antibodies  >7 publications with CLEC7A and Lung
 Intestine Antibodies  >4 publications with CLEC7A and Intestine
 Vascular Antibodies  >3 publications with CLEC7A and Vascular
 Spleen Antibodies  >3 publications with CLEC7A and Spleen
 Bone Marrow Antibodies  >3 publications with CLEC7A and Bone Marrow
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