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anti-CLIC1 antibody :: Rabbit anti-Human CLIC1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS855432
Unit / Price
0.1 mg  /  $330 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CLIC1, Polyclonal Antibody

 Also Known As   

CLIC1 Antibody

 Product Gene Name   

anti-CLIC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602872
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Lyophilized CLIC1 antibody purified by protein A column containing 0.02% NaN3
 Concentration    100ug/200ul (lot specific)
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 Source Note    Rabbit polyclonal CLIC1 (1) antibody was raised against a 14 amino acid peptide from near the N terminal residues of human CLIC1.
 Reactivity Note    Not yet tested in other species.
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 Preparation and Storage    Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
 Other Notes    Small volumes of anti-CLIC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CLIC1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-CLIC1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CLIC1 antibody    Peptide ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:200-1:500
Immunohistochemistry: 1:50-1:250
Optimal dilutions/concentrations should be determined by the end user.
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 Testing Data of anti-CLIC1 antibody    anti-CLIC1 antibody Testing Data image
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 Testing Data #2 of anti-CLIC1 antibody    anti-CLIC1 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for CLIC1. It may not necessarily be applicable to this product.
 NCBI GI #    48375182
 NCBI GeneID    1192
 NCBI Accession #    NP_001279.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001288 [Other Products]
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 UniProt Secondary Accession #    Q15089; Q502X1 [Other Products]
 UniProt Related Accession #    O00299 [Other Products]
 Molecular Weight    26,923 Da
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 NCBI Official Full Name    Homo sapiens chloride intracellular channel 1 (CLIC1), transcript variant 2, mRNA
 NCBI Official Synonym Full Names    chloride intracellular channel 1
 NCBI Official Symbol    CLIC1 [Similar Products]
 NCBI Official Synonym Symbols   
G6; NCC27
[Similar Products]
 NCBI Protein Information    chloride intracellular channel protein 1; hRNCC; p64CLCP; RNCC protein; chloride channel ABP; nuclear chloride ion channel 27; nuclear chloride ion channel protein; regulatory nuclear chloride ion channel protein
 UniProt Protein Name    Chloride intracellular channel protein 1
 UniProt Synonym Protein Names   
Chloride channel ABP; Nuclear chloride ion channel 27; NCC27; Regulatory nuclear chloride ion channel protein; hRNCC
 Protein Family    Chloride intracellular channel protein
 UniProt Gene Name    CLIC1 [Similar Products]
 UniProt Synonym Gene Names    G6; NCC27; NCC27; hRNCC [Similar Products]
 UniProt Entry Name    CLIC1_HUMAN
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 NCBI Summary for CLIC1    Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CLIC1    CLIC1: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. Belongs to the chloride channel CLIC family.

Protein type: Channel, chloride; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: extracellular space; nuclear membrane; mitochondrion; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nuclear envelope; nucleus; vesicle; brush border

Molecular Function: protein binding; chloride channel activity; voltage-gated ion channel activity

Biological Process: positive regulation of osteoblast differentiation; regulation of mitochondrial membrane potential; regulation of cell cycle; chloride transport; signal transduction
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 Research Articles on CLIC1    1. Mutation of the two charged amino acids (K37 and R29) in the putative transmembrane region of CLIC1 alters the biophysical properties of the ion channel in both artificial bilayers and cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-CLIC1 antibodyOrgans/Tissues associated with anti-CLIC1 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >8 publications with CLIC1 and Liver Diseases
 Nervous System Diseases Antibodies  >8 publications with CLIC1 and Nervous System Diseases
 Brain Diseases Antibodies  >7 publications with CLIC1 and Brain Diseases
 Neoplasm Metastasis Antibodies  >7 publications with CLIC1 and Neoplasm Metastasis
 Carcinoma, Hepatocellular Antibodies  >6 publications with CLIC1 and Carcinoma, Hepatocellular
 Necrosis Antibodies  >5 publications with CLIC1 and Necrosis
 Inflammation Antibodies  >4 publications with CLIC1 and Inflammation
 Cardiovascular Diseases Antibodies  >2 publications with CLIC1 and Cardiovascular Diseases
 Hemorrhage Antibodies  >1 publications with CLIC1 and Hemorrhage
 Anemia Antibodies  >1 publications with CLIC1 and Anemia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with CLIC1 and Blood
 Liver Antibodies  >8 publications with CLIC1 and Liver
 Brain Antibodies  >8 publications with CLIC1 and Brain
 Muscle Antibodies  >6 publications with CLIC1 and Muscle
 Bone Antibodies  >6 publications with CLIC1 and Bone
 Kidney Antibodies  >6 publications with CLIC1 and Kidney
 Stomach Antibodies  >4 publications with CLIC1 and Stomach
 Lymph Antibodies  >3 publications with CLIC1 and Lymph
 Vascular Antibodies  >3 publications with CLIC1 and Vascular
 Lymph Node Antibodies  >3 publications with CLIC1 and Lymph Node
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