Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow CLPX rightarrow Polyclonal CLPX  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • CD276 Antibody
 • TMEM209 cDNA Clone
 • thyroid stimulating hormone (TSH) ELISA Kit
 • CD27 Antibody
 • N-WASP (Ser-484-Ser-485) (WASL) Antibody
 • PGCA Antibody
 • NAD-specific glutamate dehydrogenase (gluD) Recombinant Protein
 • p130 Cas (Ab-410) Antibody
 • Threonyl t-RNA Synthetase (PL 7) Recombinant Protein
 • Crystallin Alpha A (CRYAA) Antibody
 • Alanine Aminotransferase (ALT) Recombinant Protein
 • Progesterone, PROG ELISA Kit
 • Alpha Fetoprotein (AFP) ELISA Kit
 • Tegument protein VP22 (UL49) Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-CLPX antibody :: Rabbit CLPX Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9203878
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CLPX, Polyclonal Antibody

★Popular Item★
 Also Known As   

CLPX Antibody (C-term)

 Product Synonym Names    ATP-dependent Clp protease ATP-binding subunit clpX-like; mitochondrial; CLPX
 Product Gene Name   

anti-CLPX antibody

[Similar Products]
 Antibody/Peptide Pairs    CLPX peptide (MBS9217859) is used for blocking the activity of CLPX antibody (MBS9203878)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    615611
 3D Structure    ModBase 3D Structure for O76031
Section Bar
 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Clone Number    RB24942
 Host    Rabbit
 Species Reactivity    Human (Predicted Reactivity: Mouse, Rat)
Section Bar
 Specificity    This CLPX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 449-477 amino acids from the C-terminal region of human CLPX.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Section Bar
    
 Antigen Region    449-477
 Cellular location    Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid
 Tissue location    Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain,placenta, lung, kidney and pancreas.
 Precautions    CLPX Antibody (C-term)is for research use only and not for use in diagnostic or therapeutic procedures.
 Function    Name CPX FunctionATP-dependent specificity comp onent of the Clp protease complex. Hydrolyzes ATP.Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082). Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining anormal mitochondrial nucleoid structure (PubMed:22841477). ATP-dependent unfoldase that stimulates theincorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase,thereby activating 5-aminolevulinate (ALA)synthesis, the first step in heme biosynthesis.Important for efficient erythropoiesis through upregulation of heme biosynthesis(PubMed:25957689).
Section Bar
 Preparation and Storage    Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-CLPX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-CLPX antibody

   ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of clpP (By similarity).
 Product Categories/Family for anti-CLPX antibody    Cell Biology; Metabolism; Signal Transduction
 Applications Tested/Suitable for anti-CLPX antibody   

WB, IHC-P, FC, E

 Application Notes for anti-CLPX antibody    WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Section Bar
 Western Blot (WB) of anti-CLPX antibody    Western blot analysis of lysate from human heart tissue lysate, using CLPX Antibody (C-term). MBS9203878 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.
anti-CLPX antibody Western Blot (WB) (WB) image
Section Bar
 Immunohistochemistry (IHC) of anti-CLPX antibody    CLPX antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CLPX antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-CLPX antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Flow Cytometry (FC/FACS) of anti-CLPX antibody    CLPX Antibody (C-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-CLPX antibody Flow Cytometry (FC/FACS) (FC/FACS) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CLPX. It may not necessarily be applicable to this product.
 NCBI GI #    7242140
 NCBI GeneID    10845
 NCBI Accession #    NP_006651.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006660.3 [Other Products]
Section Bar
 UniProt Primary Accession #    O76031 [Other Products]
 UniProt Secondary Accession #    Q9H4D9; A1L428; A8K8F1; B9EGI8 [Other Products]
 UniProt Related Accession #    O76031 [Other Products]
Table BarTOPTable Bar
 NCBI Official Full Name    ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
 NCBI Official Synonym Full Names    caseinolytic mitochondrial matrix peptidase chaperone subunit
 NCBI Official Symbol    CLPX [Similar Products]
 NCBI Protein Information    ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
 UniProt Protein Name    ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
 Protein Family    ATP-dependent Clp protease ATP-binding
 UniProt Gene Name    CLPX [Similar Products]
 UniProt Entry Name    CLPX_HUMAN
Section Bar
 UniProt Comments for CLPX    CLPX: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of clpP. Belongs to the ClpX chaperone family.

Protein type: Protease; Mitochondrial; Chaperone; Activator

Chromosomal Location of Human Ortholog: 15q22.31

Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; mitochondrial inner membrane; cytoplasm

Molecular Function: protein binding; protease activator activity; metal ion binding; ATP-dependent peptidase activity; unfolded protein binding; ATPase activity; ATP binding

Biological Process: proteolysis involved in cellular protein catabolic process; protein folding
Table BarTOPTable Bar
 

Product References and Citations for anti-CLPX antibody

   Martin, A., et al. Mol. Cell 29(4):441-450(2008) Bogenhagen, D.F., et al. J. Biol. Chem. 283(6):3665-3675(2008) Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) : Kang, S.G., et al. J. Biol. Chem. 280(42):35424-35432(2005) Kang, S.G., et al. J. Biol. Chem. 277(23):21095-21102(2002)
Section Bar
 Research Articles on CLPX    1. Optical trapping to assay single-molecule ClpXP unfolding and translocation of substrates consisting of domains with varying stabilities and sequences; find that ClpXP unfolds most domains by a single pathway, with kinetics that depend on the native fold and structural stability.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-CLPX antibodyDiseases associated with anti-CLPX antibody
 Reference Product  PubMed Publications
 CLPP antibody  >192 publications with CLPX and CLPP
 CLPB antibody  >26 publications with CLPX and CLPB
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with CLPX and Inflammation
 Fibrosis Antibodies  >2 publications with CLPX and Fibrosis
 Liver Diseases Antibodies  >2 publications with CLPX and Liver Diseases
 Fever Antibodies  >1 publications with CLPX and Fever
 Nervous System Diseases Antibodies  >1 publications with CLPX and Nervous System Diseases
 Cholestasis Antibodies  >1 publications with CLPX and Cholestasis
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with CLPX and Drug-Related Side Effects and Adverse Reactions
 Kidney Diseases Antibodies  >1 publications with CLPX and Kidney Diseases
 Necrosis Antibodies  >1 publications with CLPX and Necrosis
 Drug Hypersensitivity Antibodies  >1 publications with CLPX and Drug Hypersensitivity
Organs/Tissues associated with anti-CLPX antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with CLPX and Blood
 Skin Antibodies  >6 publications with CLPX and Skin
 Liver Antibodies  >5 publications with CLPX and Liver
 Muscle Antibodies  >3 publications with CLPX and Muscle
 Spleen Antibodies  >2 publications with CLPX and Spleen
 Lung Antibodies  >2 publications with CLPX and Lung
 Bone Antibodies  >1 publications with CLPX and Bone
 Eye Antibodies  >1 publications with CLPX and Eye
 Kidney Antibodies  >1 publications with CLPX and Kidney
 Lymph Node Antibodies  >1 publications with CLPX and Lymph Node
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions