NP_001120668.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cellular nucleic acid-binding protein isoform 6
NCBI Official Synonym Full Names
CCHC-type zinc finger, nucleic acid binding protein
NCBI Official Synonym Symbols
DM2; ZNF9; CNBP1; PROMM; RNF163; ZCCHC22 [Similar Products]
NCBI Protein Information
cellular nucleic acid-binding protein; zinc finger protein 273; erythroid differentiation-related; cellular nucleic acid binding protein; sterol regulatory element-binding protein; zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)
UniProt Protein Name
Cellular nucleic acid-binding protein
UniProt Synonym Protein Names
Zinc finger protein 9
UniProt Synonym Gene Names
UniProt Entry Name
CNBP_HUMAN
NCBI Summary for CNBP
This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CNBP
Function: Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.
Subcellular location: Cytoplasm
By similarity. Endoplasmic reticulum
By similarity.
Tissue specificity: Present in all tissues examined.
Involvement in disease: Dystrophia myotonica 2 (DM2) [MIM:602668]: A multisystem disease characterized by the association of proximal muscle weakness with myotonia, cardiac manifestations and cataract. Additional features can include hyperhidrosis, testicular atrophy, insulin resistance and diabetes and central nervous system anomalies in rare cases.Note: The disease is caused by mutations affecting the gene represented in this entry. The causative mutation is a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene. Ref.3
Sequence similarities: Contains 7 CCHC-type zinc fingers.
Research Articles on CNBP
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Products associated with anti-CNBP antibody
Diseases associated with anti-CNBP antibody
Organs/Tissues associated with anti-CNBP antibody
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