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anti-CNGA3 antibody :: Rabbit anti-Human CNGA3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8247326
Western Blot (WB)
Unit / Price
0.05 mL  /  $195 +1 FREE 8GB USB
0.1 mL  /  $250 +1 FREE 8GB USB
0.2 mL  /  $350 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CNGA3, Polyclonal Antibody

 Also Known As   

Anti-CNGA3 Antibody

 Product Synonym Names    CNCG3; Cyclic nucleotide-gated cation channel alpha-3; Cone photoreceptor cGMP-gated channel subunit alpha; Cyclic nucleotide-gated channel alpha-3; CNG channel alpha-3; CNG-3; CNG3
 Product Gene Name   

anti-CNGA3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    216900
 3D Structure    ModBase 3D Structure for Q16281
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes endogenous levels of CNGA3 protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Immunogen    Recombinant full length protein of human CNGA3
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-CNGA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CNGA3 antibody

   Rabbit polyclonal antibody to CNGA3
 Applications Tested/Suitable for anti-CNGA3 antibody   

Western Blot (WB)

 Application Notes for anti-CNGA3 antibody    WB: 1/500 - 1/2000
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 Western Blot (WB) of anti-CNGA3 antibody    Western blot analysis of CNGA3 expression in BT474 (A), U87 (B), mouse pancreas (C), rat liver (D) whole cell lysates.
anti-CNGA3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CNGA3. It may not necessarily be applicable to this product.
 NCBI GI #    120433600
 NCBI GeneID    1261
 NCBI Accession #    NP_001073347.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001079878.1 [Other Products]
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 UniProt Primary Accession #    Q16281 [Other Products]
 UniProt Secondary Accession #    Q4VAP7; Q53RD2; Q6ZNA7; Q9UP64; E9PF93 [Other Products]
 UniProt Related Accession #    Q16281 [Other Products]
 Molecular Weight    79,062 Da
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 NCBI Official Full Name    cyclic nucleotide-gated cation channel alpha-3 isoform 2
 NCBI Official Synonym Full Names    cyclic nucleotide gated channel alpha 3
 NCBI Official Symbol    CNGA3 [Similar Products]
 NCBI Official Synonym Symbols   
CNG3; ACHM2; CCNC1; CCNCa; CNCG3; CCNCalpha
[Similar Products]
 NCBI Protein Information    cyclic nucleotide-gated cation channel alpha-3
 UniProt Protein Name    Cyclic nucleotide-gated cation channel alpha-3
 UniProt Synonym Protein Names   
Cone photoreceptor cGMP-gated channel subunit alpha; Cyclic nucleotide-gated channel alpha-3; CNG channel alpha-3; CNG-3; CNG3
 Protein Family    Cyclic nucleotide-gated cation channel
 UniProt Gene Name    CNGA3 [Similar Products]
 UniProt Synonym Gene Names    CNCG3; CNG channel alpha-3; CNG-3; CNG3 [Similar Products]
 UniProt Entry Name    CNGA3_HUMAN
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 NCBI Summary for CNGA3    This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CNGA3    CNGA3: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. Defects in CNGA3 are the cause of achromatopsia type 2 (ACHM2); also known as total colorblindness or rod monochromacy (RMCH2). ACHM2 is an autosomal recessive condition characterized by day blindness and photophobia. In ACHM2 patients the cones are defective and the subjects see better at night. Defects in CNGA3 may be a cause of Leber congenital amaurosis (LCA), a severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near- absent pupillary responses, photophobia, high hyperopia and keratoconus. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q11.2

Cellular Component: integral to plasma membrane

Molecular Function: cGMP binding; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; ligand-gated ion channel activity; voltage-gated potassium channel activity

Biological Process: cation transport; regulation of membrane potential; signal transduction; transport

Disease: Achromatopsia 2
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 Research Articles on CNGA3    1. The c.955T>C change identified in large consanguineous Pakistani family represents the first variant of CNGA3 which was found to be responsible for the cone-rod dystrophy phenotype.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CNGA3 antibodyPathways associated with anti-CNGA3 antibody
 Reference Product  PubMed Publications
 CNGB3 antibody  >89 publications with CNGA3 and CNGB3
 GNAT2 antibody  >31 publications with CNGA3 and GNAT2
 PDE6C antibody  >17 publications with CNGA3 and PDE6C
 PDE6H antibody  >7 publications with CNGA3 and PDE6H
 OPN4 antibody  >3 publications with CNGA3 and OPN4
 GUCA1A antibody  >1 publications with CNGA3 and GUCA1A
 Products by Pathway  Pathway Diagram
 Olfactory Transduction Pathway antibodies  Olfactory Transduction Pathway Diagram
 Olfactory Transduction Pathway antibodies  Olfactory Transduction Pathway Diagram
 Visual Signal Transduction: Cones Pathway antibodies  Visual Signal Transduction: Cones Pathway Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram
Diseases associated with anti-CNGA3 antibodyOrgans/Tissues associated with anti-CNGA3 antibody
 Disease Name  Pubmed Publications
 Achromatopsia 2 Antibodies  >4 publications with CNGA3 and Achromatopsia 2
 Chromosome Aberrations Antibodies  >3 publications with CNGA3 and Chromosome Aberrations
 Inflammation Antibodies  >1 publications with CNGA3 and Inflammation
 Learning Disorders Antibodies  >1 publications with CNGA3 and Learning Disorders
 Edema Antibodies  >1 publications with CNGA3 and Edema
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >106 publications with CNGA3 and Eye
 Brain Antibodies  >20 publications with CNGA3 and Brain
 Testis Antibodies  >2 publications with CNGA3 and Testis
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