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anti-CNPase antibody :: Rabbit anti-Human CNPase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS536204 anti-CNPase antibody
Unit / Price
0.1 mg  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CNPase, Polyclonal Antibody

 Also Known As   

CNPase antibody

 Product Synonym Names    Polyclonal CNPase; Anti-CNPase; 2'; 3'-cyclic Nucleotide 3'-Phosphodiesterase
 Product Gene Name   

anti-CNPase antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    123830
 3D Structure    ModBase 3D Structure for P09543
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    CNPase antibody was purified by affinity chromatography.
 Form/Format    Affinity purified and supplied in PBS, with 0.02% NaN3.
 Concentration    1.0 mg/ml (lot specific)
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 Biological Significance    2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) is associated with brain tubulin and acts as a microtubule-associated protein in promoting microtubule assembly and distribution. CNPase is used as a marker of cell differentiation in the CNS as it is expressed primarily in committed oligodendroglial progenitors and terminally-differentiated oligodendrocytes.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    CNPase antibody was raised in rabbit using residues 68-84 [RVIVDKYRDGTKMVSAD] of the 46-48 kDa human CNPase protein as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-CNPase antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CNPase antibody

   Affinity purified Rabbit polyclonal CNPase antibody
 Product Categories/Family for anti-CNPase antibody    Neuroscience; Purified Polyclonal Antibodies
 Applications Tested/Suitable for anti-CNPase antibody   

Western Blot (WB)

 Application Notes for anti-CNPase antibody    WB: 1:500-1:1,000
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NCBI/Uniprot data below describe general gene information for CNPase. It may not necessarily be applicable to this product.
 NCBI GI #    94721261
 NCBI GeneID    1267
 NCBI Accession #    NP_149124.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_033133.4 [Other Products]
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 UniProt Primary Accession #    P09543 [Other Products]
 UniProt Related Accession #    P09543 [Other Products]
 Molecular Weight    45,099 Da
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 NCBI Official Full Name    2',3'-cyclic-nucleotide 3'-phosphodiesterase
 NCBI Official Synonym Full Names    2',3'-cyclic nucleotide 3' phosphodiesterase
 NCBI Official Symbol    CNP [Similar Products]
 NCBI Official Synonym Symbols   
CNP1
[Similar Products]
 NCBI Protein Information    2',3'-cyclic-nucleotide 3'-phosphodiesterase
 UniProt Protein Name    2',3'-cyclic-nucleotide 3'-phosphodiesterase
 UniProt Gene Name    CNP [Similar Products]
 UniProt Synonym Gene Names    CNP; CNPase [Similar Products]
 UniProt Entry Name    CN37_HUMAN
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 UniProt Comments for CNPase    CNP: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. Exists as monomers and homodimers. Belongs to the cyclic nucleotide phosphodiesterase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.4.37; Phosphodiesterase; Cell development/differentiation

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: extracellular space; microtubule; microvillus; pseudopodium; nucleoplasm; mitochondrial outer membrane; membrane; perinuclear region of cytoplasm; mitochondrial inner membrane; cytoplasm; plasma membrane; melanosome; nucleus

Molecular Function: cyclic nucleotide binding; RNA binding; 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity

Biological Process: synaptic transmission; substantia nigra development; axonogenesis; adult locomotory behavior; response to toxin; forebrain development; oligodendrocyte differentiation; response to lipopolysaccharide; microtubule cytoskeleton organization and biogenesis; regulation of mitochondrial membrane permeability; cyclic nucleotide catabolic process; aging
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 Research Articles on CNPase    1. kidneys express 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), and renal CNPase mediates in part the renal 2',3'-cAMP-adenosine pathway
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CNPase antibodyDiseases associated with anti-CNPase antibody
 Products by Pathway  Pathway Diagram
 Glial Cell Differentiation Pathway antibodies  Glial Cell Differentiation Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >254 publications with CNPase and Nervous System Diseases
 Brain Diseases Antibodies  >192 publications with CNPase and Brain Diseases
 Disease Models, Animal Antibodies  >100 publications with CNPase and Disease Models, Animal
 Inflammation Antibodies  >73 publications with CNPase and Inflammation
 Kidney Diseases Antibodies  >54 publications with CNPase and Kidney Diseases
 Hypertrophy Antibodies  >43 publications with CNPase and Hypertrophy
 Fibrosis Antibodies  >42 publications with CNPase and Fibrosis
 Necrosis Antibodies  >39 publications with CNPase and Necrosis
 Liver Diseases Antibodies  >26 publications with CNPase and Liver Diseases
 Hemorrhage Antibodies  >18 publications with CNPase and Hemorrhage
Organs/Tissues associated with anti-CNPase antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >908 publications with CNPase and Brain
 Blood Antibodies  >542 publications with CNPase and Blood
 Nerve Antibodies  >485 publications with CNPase and Nerve
 Vascular Antibodies  >361 publications with CNPase and Vascular
 Heart Antibodies  >334 publications with CNPase and Heart
 Muscle Antibodies  >316 publications with CNPase and Muscle
 Kidney Antibodies  >185 publications with CNPase and Kidney
 Bone Antibodies  >126 publications with CNPase and Bone
 Spinal Cord Antibodies  >115 publications with CNPase and Spinal Cord
 Lung Antibodies  >95 publications with CNPase and Lung
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