NP_000080.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
129,314 Da
NCBI Official Full Name
collagen alpha-2(I) chain
NCBI Official Synonym Full Names
collagen type I alpha 2 chain
NCBI Protein Information
collagen alpha-2(I) chain
UniProt Protein Name
Collagen alpha-2(I) chain
UniProt Synonym Protein Names
Alpha-2 type I collagen
NCBI Summary for COL1A2
This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
UniProt Comments for COL1A2
Type I collagen is a member of group I collagen (fibrillar forming collagen).
Research Articles on COL1A2
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Products associated with anti-COL1A2 antibody
Pathways associated with anti-COL1A2 antibody
Diseases associated with anti-COL1A2 antibody
Organs/Tissues associated with anti-COL1A2 antibody
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