NP_001274689.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 160 kDa Predicted: 164 kDa
NCBI Official Full Name
collagen alpha-6(IV) chain isoform 5
NCBI Official Synonym Full Names
collagen type IV alpha 6 chain
NCBI Protein Information
collagen alpha-6(IV) chain
UniProt Protein Name
Collagen alpha-6(IV) chain
NCBI Summary for COL4A6
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
UniProt Comments for COL4A6
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Research Articles on COL4A6
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Pathways associated with anti-COL4A6 antibody
Diseases associated with anti-COL4A6 antibody
Organs/Tissues associated with anti-COL4A6 antibody
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