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anti-COL8A1 antibody :: Rabbit anti-Human COL8A1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7004232
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

COL8A1, Polyclonal Antibody

★Popular Item★
 Also Known As   

COL8A1 Antibody

 Product Synonym Names    Collagen alpha-1(VIII) chain; Endothelial collagen; COL8A1; C3orf7
 Product Gene Name   

anti-COL8A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    120251
 3D Structure    ModBase 3D Structure for P27658
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%,Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Collagen alpha-1(VIII) chain protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-99356 / sc-99357
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-COL8A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-COL8A1 antibody

   Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.
 Applications Tested/Suitable for anti-COL8A1 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

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 Western Blot (WB) of anti-COL8A1 antibody    Western Blot
Positive WB detected in:HepG2 whole cell lysate,Hela whole cell lysate,Mouse heart tissue,Mouse liver tissue,Mouse lung tissue,Mouse kidney tissue,Mouse brain tissue,Mouse skeletal muscle tissue
All lanes: COL8A1 antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 74 kDa
Observed band size: 74,50 kDa

anti-COL8A1 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-COL8A1 antibody    Immunofluorescent analysis of U251 cells using MBS7004232 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-COL8A1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for COL8A1. It may not necessarily be applicable to this product.
 NCBI GI #    17738302
 NCBI GeneID    1295
 NCBI Accession #    NP_001841.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001850.4 [Other Products]
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 UniProt Primary Accession #    P27658 [Other Products]
 UniProt Secondary Accession #    Q53XI6; Q96D07; D3DN42 [Other Products]
 UniProt Related Accession #    P27658 [Other Products]
 Molecular Weight    73,364 Da
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 NCBI Official Full Name    collagen alpha-1(VIII) chain
 NCBI Official Synonym Full Names    collagen type VIII alpha 1
 NCBI Official Symbol    COL8A1 [Similar Products]
 NCBI Official Synonym Symbols   
C3orf7
[Similar Products]
 NCBI Protein Information    collagen alpha-1(VIII) chain
 UniProt Protein Name    Collagen alpha-1(VIII) chain
 UniProt Synonym Protein Names   
Endothelial collagen
 Protein Family    Collagen
 UniProt Gene Name    COL8A1 [Similar Products]
 UniProt Synonym Gene Names    C3orf7 [Similar Products]
 UniProt Entry Name    CO8A1_HUMAN
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 NCBI Summary for COL8A1    This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Dec 2011]
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 UniProt Comments for COL8A1    COL8A1: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.

Protein type: Secreted, signal peptide; Secreted; Extracellular matrix

Chromosomal Location of Human Ortholog: 3q12.3

Cellular Component: collagen type VIII; endoplasmic reticulum lumen; extracellular matrix; extracellular region; intracellular membrane-bound organelle

Molecular Function: protein binding

Biological Process: angiogenesis; camera-type eye morphogenesis; cell adhesion; collagen catabolic process; epithelial cell proliferation; extracellular matrix disassembly; extracellular matrix organization and biogenesis
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 Research Articles on COL8A1    1. Data indicate that complement factor H (CFH) R1210C and common variants in COL8A1 and RAD51B plus six genes contribute predictive information for advanced macular degeneration (AMD) beyond macular and behavioral phenotypes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-COL8A1 antibodyPathways associated with anti-COL8A1 antibody
 Reference Product  PubMed Publications
 COL8A2 antibody  >10 publications with COL8A1 and COL8A2
 COL4A2 antibody  >2 publications with COL8A1 and COL4A2
 COL4A1 antibody  >2 publications with COL8A1 and COL4A1
 COL1A1 antibody  >2 publications with COL8A1 and COL1A1
 COL12A1 antibody  >2 publications with COL8A1 and COL12A1
 COL3A1 antibody  >1 publications with COL8A1 and COL3A1
 Products by Pathway  Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
Diseases associated with anti-COL8A1 antibodyOrgans/Tissues associated with anti-COL8A1 antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >4 publications with COL8A1 and Kidney Diseases
 Inflammation Antibodies  >3 publications with COL8A1 and Inflammation
 Congenital Abnormalities Antibodies  >3 publications with COL8A1 and Congenital Abnormalities
 Fibrosis Antibodies  >2 publications with COL8A1 and Fibrosis
 Disease Models, Animal Antibodies  >2 publications with COL8A1 and Disease Models, Animal
 Atherosclerosis Antibodies  >2 publications with COL8A1 and Atherosclerosis
 Liver Neoplasms Antibodies  >2 publications with COL8A1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with COL8A1 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >2 publications with COL8A1 and Liver Diseases
 Lung Diseases Antibodies  >1 publications with COL8A1 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >11 publications with COL8A1 and Eye
 Kidney Antibodies  >7 publications with COL8A1 and Kidney
 Vascular Antibodies  >6 publications with COL8A1 and Vascular
 Muscle Antibodies  >4 publications with COL8A1 and Muscle
 Connective Tissue Antibodies  >2 publications with COL8A1 and Connective Tissue
 Ear Antibodies  >1 publications with COL8A1 and Ear
 Brain Antibodies  >1 publications with COL8A1 and Brain
 Lung Antibodies  >1 publications with COL8A1 and Lung
 Bone Antibodies  >1 publications with COL8A1 and Bone
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