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anti-COMMD1 antibody :: Rabbit anti-Human COMMD1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7043683
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

COMMD1, Polyclonal Antibody

★Popular Item★
 Also Known As   

COMMD1 Antibody

 Product Synonym Names    COMM domain-containing protein 1; Protein Murr1; COMMD1; C2orf5; MURR1
 Product Gene Name   

anti-COMMD1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607238
 3D Structure    ModBase 3D Structure for Q8N668
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human COMM domain-containing protein 1 protein (1-190AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-107497 / sc-107500 / sc-107498 / sc-98286
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-COMMD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-COMMD1 antibody

   Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:15799966, PubMed:17183367, PubMed:20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214, PubMed:20237237, PubMed:21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:21483833). Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). Can bind one copper ion per monomer (PubMed:17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:18940794). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:20458141).
 Applications Tested/Suitable for anti-COMMD1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

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 Western Blot (WB) of anti-COMMD1 antibody    Western blot
All lanes:  COMMD1antibody at 5.36ug/ml
Lane 1 : A549 whole cell lysate
Lane 2 : Jurkat whole cell lysate
Lane 3 : MCF7 whole cell lysate
Lane 4 : Hela whole cell lysate
Lane 5 : HepG-2 whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 22,18 kDa
Observed band size: 21 kDa

anti-COMMD1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-COMMD1 antibody    Immunohistochemistry of paraffin-embedded human liver cancer using MBS7043683 at dilution 1:100
anti-COMMD1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-COMMD1 antibody    Immunohistochemistry of paraffin-embedded human adrenal gland tissue using MBS7043683 at dilution 1:100
anti-COMMD1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunoprecipitation (IP) of anti-COMMD1 antibody    Immunoprecipitating COMMD1 in HepG2 whole cell lysate
Lane 1: Rabbit monoclonal IgG(1ug) instead of MBS7043683 in HepG2 whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
Lane 2: MBS7043683(4ug)+ HepG2 whole cell lysate(500ug)
Lane 3: HepG2 whole cell lysate (20ug)

anti-COMMD1 antibody Immunoprecipitation (IP) (IP) image
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NCBI/Uniprot data below describe general gene information for COMMD1. It may not necessarily be applicable to this product.
 NCBI GI #    22749079
 NCBI GeneID    150684
 NCBI Accession #    NP_689729.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_152516.3 [Other Products]
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 UniProt Primary Accession #    Q8N668 [Other Products]
 UniProt Secondary Accession #    Q96GS0; B4DFQ4 [Other Products]
 UniProt Related Accession #    Q8N668 [Other Products]
 Molecular Weight    17,665 Da
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 NCBI Official Full Name    COMM domain-containing protein 1 isoform 1
 NCBI Official Synonym Full Names    copper metabolism domain containing 1
 NCBI Official Symbol    COMMD1 [Similar Products]
 NCBI Official Synonym Symbols   
MURR1; C2orf5
[Similar Products]
 NCBI Protein Information    COMM domain-containing protein 1
 UniProt Protein Name    COMM domain-containing protein 1
 UniProt Synonym Protein Names   
Protein Murr1
 Protein Family    COMM domain-containing protein
 UniProt Gene Name    COMMD1 [Similar Products]
 UniProt Synonym Gene Names    C2orf5; MURR1 [Similar Products]
 UniProt Entry Name    COMD1_HUMAN
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 NCBI Summary for COMMD1    COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]
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 UniProt Comments for COMMD1    COMMD1: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 2p15

Cellular Component: Cul2-RING ubiquitin ligase complex; cytoplasm; early endosome; nucleoplasm; nucleus; recycling endosome

Molecular Function: copper ion binding; identical protein binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein homodimerization activity

Biological Process: copper ion homeostasis; Golgi to plasma membrane transport; inhibition of NF-kappaB transcription factor; plasma membrane to endosome transport; positive regulation of protein ubiquitination; regulation of proteasomal ubiquitin-dependent protein catabolic process
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 Research Articles on COMMD1    1. COMMD1 expression is associated with poor prognosis in diffuse large B-cell lymphoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-COMMD1 antibodyPathways associated with anti-COMMD1 antibody
 Reference Product  PubMed Publications
 ATP7B antibody  >27 publications with COMMD1 and ATP7B
 RELA antibody  >16 publications with COMMD1 and RELA
 XIAP antibody  >8 publications with COMMD1 and XIAP
 CUL2 antibody  >5 publications with COMMD1 and CUL2
 NFKBIA antibody  >4 publications with COMMD1 and NFKBIA
 COMMD6 antibody  >2 publications with COMMD1 and COMMD6
 NMRAL1 antibody  >1 publications with COMMD1 and NMRAL1
 Products by Pathway  Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
Diseases associated with anti-COMMD1 antibodyOrgans/Tissues associated with anti-COMMD1 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >29 publications with COMMD1 and Liver Diseases
 Nervous System Diseases Antibodies  >22 publications with COMMD1 and Nervous System Diseases
 Inflammation Antibodies  >14 publications with COMMD1 and Inflammation
 Dog Diseases Antibodies  >12 publications with COMMD1 and Dog Diseases
 Disease Models, Animal Antibodies  >8 publications with COMMD1 and Disease Models, Animal
 Liver Cirrhosis Antibodies  >8 publications with COMMD1 and Liver Cirrhosis
 Necrosis Antibodies  >7 publications with COMMD1 and Necrosis
 Fibrosis Antibodies  >7 publications with COMMD1 and Fibrosis
 Hepatitis, Chronic Antibodies  >3 publications with COMMD1 and Hepatitis, Chronic
 Drug-Induced Liver Injury Antibodies  >2 publications with COMMD1 and Drug-Induced Liver Injury
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with COMMD1 and Blood
 Brain Antibodies  >13 publications with COMMD1 and Brain
 Embryonic Tissue Antibodies  >5 publications with COMMD1 and Embryonic Tissue
 Placenta Antibodies  >4 publications with COMMD1 and Placenta
 Kidney Antibodies  >4 publications with COMMD1 and Kidney
 Intestine Antibodies  >4 publications with COMMD1 and Intestine
 Lung Antibodies  >4 publications with COMMD1 and Lung
 Muscle Antibodies  >2 publications with COMMD1 and Muscle
 Prostate Antibodies  >2 publications with COMMD1 and Prostate
 Vascular Antibodies  >2 publications with COMMD1 and Vascular
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