NP_009294.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,449 Da
NCBI Official Full Name
catechol O-methyltransferase isoform S-COMT
NCBI Official Synonym Full Names
catechol-O-methyltransferase
NCBI Official Synonym Symbols
NCBI Protein Information
catechol O-methyltransferase; epididymis secretory sperm binding protein Li 98n
UniProt Protein Name
Catechol O-methyltransferase
UniProt Entry Name
COMT_HUMAN
NCBI Summary for COMT
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
UniProt Comments for COMT
COMT: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Belongs to the mammalian catechol-O-methyltransferase family. 2 isoforms of the human protein are produced by alternative initiation.
Protein type: Amino Acid Metabolism - tyrosine; Membrane protein, integral; EC 2.1.1.6; Methyltransferase
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: postsynaptic membrane; membrane; mitochondrion; axon; integral to membrane; plasma membrane; dendritic spine; cytosol
Molecular Function: protein binding; magnesium ion binding; O-methyltransferase activity; catechol O-methyltransferase activity
Biological Process: methylation; response to drug; estrogen metabolic process; cellular response to phosphate starvation; neurotransmitter catabolic process; dopamine catabolic process; negative regulation of smooth muscle cell proliferation; short-term memory; response to pain; response to lipopolysaccharide; learning; female pregnancy; reproductive process in a multicellular organism; response to organic cyclic substance; positive regulation of homocysteine metabolic process; negative regulation of dopamine metabolic process; synaptic transmission; xenobiotic metabolic process; regulation of sensory perception of pain; developmental process; neurotransmitter biosynthetic process
Disease: Schizophrenia; Panic Disorder 1
Research Articles on COMT
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Products associated with anti-COMT antibody
Pathways associated with anti-COMT antibody
Diseases associated with anti-COMT antibody
Organs/Tissues associated with anti-COMT antibody
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