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anti-COMT antibody :: Goat COMT Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421132
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

COMT, Polyclonal Antibody

 Also Known As   

Goat anti-COMT (internal) Antibody

 Product Synonym Names    Goat Anti-COMT (N Terminus) Antibody; COMT; catechol-O-methyltransferase; COMT antibody; catechol-O-methyltransferase antibody; COMT (internal)
 Product Gene Name   

anti-COMT antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: COMT (MBS421132)
Biotin Conjugated Antibody: COMT (MBS423718)
 Antibody/Peptide Pairs    COMT peptide (MBS426652) is used for blocking the activity of COMT antibody (MBS421132)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QDIIPQLKKK YDVD
 OMIM    103780
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-QDIIPQLKKKYDVD, from the internal region of the protein sequence according to NP_000745.1; NP_009294.1.
 Epitope    Internal region
 Note    This antibody is expected to recognise both reported isoforms (NP_000745.1 and NP_009294.1)
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-COMT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-COMT antibody   

Peptide ELISA (EIA), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-COMT antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 28kDa band and faint 25kDa band observed in human testis lysates (calculated MW of 30. 0kDa according to NP_000745.1 and 24.5kDa according to NP_009294.1). Recommended concentration: 0. 03-0.1ug/ml.
Enzyme immunoassay: Sandwich-type ELISA with increasing amount of recombinant COMTcaptured by a rabbit antibody. Recommended reporter concentration: 0.5-2ug/ml.
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 Western Blot (WB) of anti-COMT antibody    Staining of human testis lysate (35ug protein in RIPA buffer) (0. 03ug/ml). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-COMT antibody Western Blot (WB) (WB) image
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 Testing Data of anti-COMT antibody    (0.5ug/ml) as the reporter with as the capture rabbit antibody (2.5ug/ml).
anti-COMT antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for COMT. It may not necessarily be applicable to this product.
 NCBI GI #    4502969
 NCBI GeneID    1312
 NCBI Accession #    NP_000745.1 [Other Products]
 NCBI Related Accession #    NP_009294.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000754.3 [Other Products]
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 UniProt Secondary Accession #    Q6IB07; Q6ICE6; Q9BWC7; A8MPV9 [Other Products]
 UniProt Related Accession #    P21964 [Other Products]
 Molecular Weight    24,449 Da
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 NCBI Official Full Name    catechol O-methyltransferase isoform MB-COMT
 NCBI Official Synonym Full Names    catechol-O-methyltransferase
 NCBI Official Symbol    COMT [Similar Products]
 NCBI Official Synonym Symbols   
HEL-S-98n
[Similar Products]
 NCBI Protein Information    catechol O-methyltransferase
 UniProt Protein Name    Catechol O-methyltransferase
 Protein Family    Catechol O-methyltransferase
 UniProt Gene Name    COMT [Similar Products]
 UniProt Entry Name    COMT_HUMAN
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 NCBI Summary for COMT    Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
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 UniProt Comments for COMT    COMT: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Belongs to the mammalian catechol-O-methyltransferase family. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Amino Acid Metabolism - tyrosine; Methyltransferase; Membrane protein, integral; EC 2.1.1.6

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: axon; cytosol; dendritic spine; integral to membrane; membrane; mitochondrion; plasma membrane; postsynaptic membrane

Molecular Function: catechol O-methyltransferase activity; magnesium ion binding; methyltransferase activity; O-methyltransferase activity; protein binding

Biological Process: cellular response to phosphate starvation; developmental process; dopamine catabolic process; estrogen metabolic process; female pregnancy; learning; methylation; negative regulation of dopamine metabolic process; negative regulation of smooth muscle cell proliferation; neurotransmitter catabolic process; positive regulation of homocysteine metabolic process; regulation of sensory perception of pain; reproductive process in a multicellular organism; response to drug; response to lipopolysaccharide; response to organic cyclic substance; response to pain; short-term memory

Disease: Panic Disorder 1; Schizophrenia
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 Research Articles on COMT    1. COMT genotype has a strong impact on brain responses (oscillatory activity) during WM performance likely a consequence of compensatory activity during the delay and response periods.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-COMT antibodyPathways associated with anti-COMT antibody
 Reference Product  PubMed Publications
 SLC6A4 antibody  >154 publications with COMT and SLC6A4
 CYP1B1 antibody  >129 publications with COMT and CYP1B1
 CYP1A1 antibody  >120 publications with COMT and CYP1A1
 MAOA antibody  >113 publications with COMT and MAOA
 DBH antibody  >87 publications with COMT and DBH
 MAOB antibody  >37 publications with COMT and MAOB
 DDC antibody  >36 publications with COMT and DDC
 PNMT antibody  >29 publications with COMT and PNMT
 UGT2B7 antibody  >22 publications with COMT and UGT2B7
 UGT1A1 antibody  >16 publications with COMT and UGT1A1
 Products by Pathway  Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Dopamine Clearance From The Synaptic Cleft Pathway antibodies  Dopamine Clearance From The Synaptic Cleft Pathway Diagram
 Dopamine Metabolism Pathway antibodies  Dopamine Metabolism Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Enzymatic Degradation Of Dopamine By Monoamine Oxidase Pathway antibodies  Enzymatic Degradation Of Dopamine By Monoamine Oxidase Pathway Diagram
 Enzymatic Degradation Of Dopamine By COMT Pathway antibodies  Enzymatic Degradation Of Dopamine By COMT Pathway Diagram
 Estrogen Metabolism Pathway antibodies  Estrogen Metabolism Pathway Diagram
 L-dopa Degradation Pathway antibodies  L-dopa Degradation Pathway Diagram
Diseases associated with anti-COMT antibodyOrgans/Tissues associated with anti-COMT antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >1135 publications with COMT and Mental Disorders
 Nervous System Diseases Antibodies  >744 publications with COMT and Nervous System Diseases
 Schizophrenia Antibodies  >554 publications with COMT and Schizophrenia
 Movement Disorders Antibodies  >436 publications with COMT and Movement Disorders
 Pain Antibodies  >203 publications with COMT and Pain
 Cognition Disorders Antibodies  >178 publications with COMT and Cognition Disorders
 Cardiovascular Diseases Antibodies  >166 publications with COMT and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >163 publications with COMT and Breast Neoplasms
 Depressive Disorder Antibodies  >135 publications with COMT and Depressive Disorder
 Bipolar Disorder Antibodies  >133 publications with COMT and Bipolar Disorder
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1206 publications with COMT and Brain
 Blood Antibodies  >717 publications with COMT and Blood
 Liver Antibodies  >274 publications with COMT and Liver
 Nerve Antibodies  >153 publications with COMT and Nerve
 Heart Antibodies  >140 publications with COMT and Heart
 Muscle Antibodies  >139 publications with COMT and Muscle
 Vascular Antibodies  >133 publications with COMT and Vascular
 Kidney Antibodies  >110 publications with COMT and Kidney
 Lung Antibodies  >55 publications with COMT and Lung
 Intestine Antibodies  >44 publications with COMT and Intestine
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