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anti-COPS4 antibody :: Rabbit anti-Human COPS4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1497414
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

COPS4, Polyclonal Antibody

★Popular Item★
 Also Known As   

COPS4 Antibody

 Product Synonym Names    SGN4; Signalosome subunit 4; JAB1-containing signalosome subunit 4; COPS4; CSN4
 Product Gene Name   

anti-COPS4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    616008
 3D Structure    ModBase 3D Structure for Q9BT78
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human COP9 signalosome complex subunit 4 protein (1-310aa)
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-COPS4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-COPS4 antibody

   Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
 Applications Tested/Suitable for anti-COPS4 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-COPS4 antibody    Recommended dilution: WB:1:200-1000
IHC:1:20-1:200
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 Western Blot (WB) of anti-COPS4 antibody    Western blot
All lanes: COPS4 antibody at 8ug/ml
Lane 1:Hela whole cell lysate
Lane 2:HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 47,41 kDa
Observed band size: 46 kDa

anti-COPS4 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-COPS4 antibody    Immunohistochemistry of paraffin-embedded human breast cancer using MBS1497414 at dilution 1:100
anti-COPS4 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-COPS4 antibody    Immunohistochemistry of paraffin-embedded human pancreas tissue using MBS1497414 at dilution 1:100
anti-COPS4 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for COPS4. It may not necessarily be applicable to this product.
 NCBI GI #    384367993
 NCBI GeneID    51138
 NCBI Accession #    NP_001244935.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001258006.1 [Other Products]
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 UniProt Primary Accession #    Q9BT78 [Other Products]
 UniProt Secondary Accession #    Q561W7; Q9NW31; Q9Y677; B3KN88; B3KST5 [Other Products]
 UniProt Related Accession #    Q9BT78 [Other Products]
 Molecular Weight    40,197 Da
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 NCBI Official Full Name    COP9 signalosome complex subunit 4 isoform 2
 NCBI Official Synonym Full Names    COP9 signalosome subunit 4
 NCBI Official Symbol    COPS4 [Similar Products]
 NCBI Official Synonym Symbols   
CSN4
[Similar Products]
 NCBI Protein Information    COP9 signalosome complex subunit 4
 UniProt Protein Name    COP9 signalosome complex subunit 4
 UniProt Synonym Protein Names   
JAB1-containing signalosome subunit 4
 UniProt Gene Name    COPS4 [Similar Products]
 UniProt Synonym Gene Names    CSN4; SGN4; Signalosome subunit 4 [Similar Products]
 UniProt Entry Name    CSN4_HUMAN
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 NCBI Summary for COPS4    This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
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 UniProt Comments for COPS4    COPS4: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Belongs to the CSN4 family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 4q21.22

Cellular Component: cell junction; cytosol; nucleoplasm; nucleus; signalosome; synaptic vesicle

Molecular Function: NEDD8-specific protease activity; protein binding

Biological Process: cullin deneddylation; DNA repair; nucleotide-excision repair; nucleotide-excision repair, DNA damage recognition; protein deneddylation; transcription-coupled nucleotide-excision repair
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 Research Articles on COPS4    1. CSN4 silencing decreases CSN5 protein levels and suggest that the CSN4 effects on sGCA1 and p53 proteins are mediated by CSN5.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-COPS4 antibodyPathways associated with anti-COPS4 antibody
 Reference Product  PubMed Publications
 COPS5 antibody  >2 publications with COPS4 and COPS5
 CUL1 antibody  >1 publications with COPS4 and CUL1
 COPS2 antibody  >1 publications with COPS4 and COPS2
 COPS6 antibody  >1 publications with COPS4 and COPS6
 Products by Pathway  Pathway Diagram
 DNA Damage Recognition In GG-NER Pathway antibodies  DNA Damage Recognition In GG-NER Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Formation Of TC-NER Pre-Incision Complex Pathway antibodies  Formation Of TC-NER Pre-Incision Complex Pathway Diagram
 Global Genome Nucleotide Excision Repair (GG-NER) Pathway antibodies  Global Genome Nucleotide Excision Repair (GG-NER) Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Transcription-Coupled Nucleotide Excision Repair (TC-NER) Pathway antibodies  Transcription-Coupled Nucleotide Excision Repair (TC-NER) Pathway Diagram
Diseases associated with anti-COPS4 antibodyOrgans/Tissues associated with anti-COPS4 antibody
 Disease Name  Pubmed Publications
 Prostatic Diseases Antibodies  >1 publications with COPS4 and Prostatic Diseases
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >1 publications with COPS4 and Prostate
 Brain Antibodies  >1 publications with COPS4 and Brain
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