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anti-COX10 antibody :: COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS716684 anti-COX10 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase, Polyclonal Antibody

 Also Known As   

Rabbit anti-human COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) polyclonal Antibody

 Product Gene Name   

anti-COX10 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602125
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 Clonality    Polyclonal
 Isotype    IgG
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human COX10
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-54061 / sc-54061 / sc-54062 / sc-134792
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-COX10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-COX10 antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for COX10. It may not necessarily be applicable to this product.
 NCBI GI #    13623563
 NCBI GeneID    1352
 NCBI Accession #    AAH06394.1 [Other Products]
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 UniProt Secondary Accession #    O15334; Q969F7; B2R6U5; B4DJ50 [Other Products]
 UniProt Related Accession #    Q12887 [Other Products]
 Molecular Weight    27,594 Da [Similar Products]
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 NCBI Official Full Name    COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)
 NCBI Official Synonym Full Names    cytochrome c oxidase assembly homolog 10 (yeast)
 NCBI Official Symbol    COX10 [Similar Products]
 NCBI Protein Information    protoheme IX farnesyltransferase, mitochondrial; heme O synthase; heme A: farnesyltransferase; cytochrome c oxidase subunit X; cytochrome c oxidase assembly protein; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase
 UniProt Protein Name    Protoheme IX farnesyltransferase, mitochondrial
 UniProt Synonym Protein Names   
Heme O synthase
 Protein Family    Probable protoheme IX farnesyltransferase
 UniProt Gene Name    COX10 [Similar Products]
 UniProt Entry Name    COX10_HUMAN
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 NCBI Summary for COX10    Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq, Jul 2008]
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 UniProt Comments for COX10    COX10: Converts protoheme IX and farnesyl diphosphate to heme O. Defects in COX10 are a cause of mitochondrial complex IV deficiency (MT-C4D); also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome. Defects in COX10 are a cause of Leigh syndrome (LS). LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions. Belongs to the UbiA prenyltransferase family.

Protein type: Membrane protein, integral; EC 2.5.1.-; Transferase; Membrane protein, multi-pass; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Energy Metabolism - oxidative phosphorylation

Chromosomal Location of Human Ortholog: 17p12

Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane

Molecular Function: cytochrome-c oxidase activity; farnesyltranstransferase activity; protoheme IX farnesyltransferase activity

Biological Process: mitochondrial fission; heme o biosynthetic process; respiratory chain complex IV assembly; cellular respiration; porphyrin metabolic process; aerobic respiration; mitochondrial electron transport, cytochrome c to oxygen; heme a biosynthetic process; heme biosynthetic process

Disease: Leigh Syndrome; Mitochondrial Complex Iv Deficiency
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 Research Articles on COX10    1. ISCU and COX10 are target genes of miR-210 related to mitochondrial metabolism
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-COX10 antibodyPathways associated with anti-COX10 antibody
 Reference Product  PubMed Publications
 SCO2 antibody  >14 publications with COX10 and SCO2
 SCO1 antibody  >13 publications with COX10 and SCO1
 SURF1 antibody  >13 publications with COX10 and SURF1
 COX15 antibody  >13 publications with COX10 and COX15
 COX11 antibody  >5 publications with COX10 and COX11
 CDRT1 antibody  >2 publications with COX10 and CDRT1
 Products by Pathway  Pathway Diagram
 Cytochrome C Oxidase Pathway antibodies  Cytochrome C Oxidase Pathway Diagram
 Cytochrome C Oxidase Pathway antibodies  Cytochrome C Oxidase Pathway Diagram
 Heme Biosynthesis Pathway antibodies  Heme Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Porphyrins Pathway antibodies  Metabolism Of Porphyrins Pathway Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
Diseases associated with anti-COX10 antibodyOrgans/Tissues associated with anti-COX10 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >25 publications with COX10 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >8 publications with COX10 and Congenital Abnormalities
 Disease Models, Animal Antibodies  >5 publications with COX10 and Disease Models, Animal
 Liver Diseases Antibodies  >4 publications with COX10 and Liver Diseases
 Cardiovascular Diseases Antibodies  >3 publications with COX10 and Cardiovascular Diseases
 Dementia Antibodies  >2 publications with COX10 and Dementia
 Neurobehavioral Manifestations Antibodies  >1 publications with COX10 and Neurobehavioral Manifestations
 Hepatomegaly Antibodies  >1 publications with COX10 and Hepatomegaly
 Kidney Diseases Antibodies  >1 publications with COX10 and Kidney Diseases
 Anemia Antibodies  >1 publications with COX10 and Anemia
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >15 publications with COX10 and Muscle
 Brain Antibodies  >6 publications with COX10 and Brain
 Liver Antibodies  >5 publications with COX10 and Liver
 Heart Antibodies  >5 publications with COX10 and Heart
 Skin Antibodies  >2 publications with COX10 and Skin
 Testis Antibodies  >2 publications with COX10 and Testis
 Blood Antibodies  >1 publications with COX10 and Blood
 Spleen Antibodies  >1 publications with COX10 and Spleen
 Placenta Antibodies  >1 publications with COX10 and Placenta
 Connective Tissue Antibodies  >1 publications with COX10 and Connective Tissue
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