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anti-PTGS2 antibody :: Goat COX2/PTGS2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421257
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

COX2/PTGS2, Polyclonal Antibody

 Also Known As   

Goat anti-COX2/PTGS2 Antibody

 Product Synonym Names    PTGS2; COX2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; prostaglandin G/H synthase and cyclooxygenase; GRIPGHS; cyclooxygenase 2b; PTGS2 antibody; COX2 antibody; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) antibody; COX-2 antibody; PHS-2 antibody; PGG/HS antibody; PGHS-2 antibody; hCox-2 antibody; prostaglandin G/H synthase and cyclooxygenase antibody; GRIPGHS antibody; cyclooxygenase 2b antibody; COX2 / PTGS2
 Product Gene Name   

anti-PTGS2 antibody

[Similar Products]
 Product Synonym Gene Name    COX2 [Similar Products]
 Antibody/Peptide Pairs    COX2 / PTGS2 peptide (MBS425672) is used for blocking the activity of COX2/PTGS2 antibody (MBS421257)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    NPTVLLKERS TEL
 OMIM    600262
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-NPTVLLKERSTEL, from the C Terminus of the protein sequence according to NP_000954.1.
 Epitope    C Terminus
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1745
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-PTGS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PTGS2 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-PTGS2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 70-75kDa band observed in H460 lysates (predicted MW of 69kDa according to NP_000954.1). Recommended for use at 0.5-2ug/ml.
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 Western Blot (WB) of anti-PTGS2 antibody    Staining (0.5ug/ml) of H460 lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-PTGS2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PTGS2. It may not necessarily be applicable to this product.
 NCBI GI #    4506265
 NCBI GeneID    5743
 NCBI Accession #    NP_000954.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000963.3 [Other Products]
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 UniProt Secondary Accession #    Q16876; A8K802 [Other Products]
 UniProt Related Accession #    P35354 [Other Products]
 Molecular Weight    68,996 Da
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 NCBI Official Full Name    prostaglandin G/H synthase 2
 NCBI Official Synonym Full Names    prostaglandin-endoperoxide synthase 2
 NCBI Official Symbol    PTGS2 [Similar Products]
 NCBI Official Synonym Symbols   
COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS
[Similar Products]
 NCBI Protein Information    prostaglandin G/H synthase 2
 UniProt Protein Name    Prostaglandin G/H synthase 2
 UniProt Synonym Protein Names   
Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
 Protein Family    Prostaglandin G/H synthase
 UniProt Gene Name    PTGS2 [Similar Products]
 UniProt Synonym Gene Names    COX2; COX-2; PGH synthase 2; PGHS-2 [Similar Products]
 UniProt Entry Name    PGH2_HUMAN
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 NCBI Summary for PTGS2    Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
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 UniProt Comments for PTGS2    COX-2: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family.

Protein type: Oxidoreductase; Lipid Metabolism - arachidonic acid; EC 1.14.99.1

Chromosomal Location of Human Ortholog: 1q25.2-q25.3

Cellular Component: caveola; cytoplasm; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; neuron projection; nucleus; protein complex

Molecular Function: arachidonate 15-lipoxygenase activity; enzyme binding; heme binding; lipid binding; metal ion binding; peroxidase activity; prostaglandin-endoperoxide synthase activity; protein binding; protein homodimerization activity

Biological Process: angiogenesis; bone mineralization; brown fat cell differentiation; cell motility; cyclooxygenase pathway; decidualization; embryo implantation; hair cycle; inflammatory response; learning; lipoxygenase pathway; memory; negative regulation of calcium ion transport; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of smooth muscle contraction; negative regulation of synaptic transmission, dopaminergic; nicotinamide metabolic process; ovulation; positive regulation of apoptosis; positive regulation of fever; positive regulation of NF-kappaB import into nucleus; positive regulation of nitric oxide biosynthetic process; positive regulation of prostaglandin biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle contraction; positive regulation of synaptic plasticity; positive regulation of synaptic transmission, glutamatergic; positive regulation of vasoconstriction; prostaglandin biosynthetic process; prostaglandin metabolic process; regulation of blood pressure; regulation of inflammatory response; response to drug; response to estradiol stimulus; response to fructose stimulus; response to glucocorticoid stimulus; response to lipopolysaccharide; response to lithium ion; response to manganese ion; response to oxidative stress; response to vitamin D; sensory perception of pain
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 Research Articles on PTGS2    1. In the presence of diverticular disease there is a loss of modulation by both COX isoforms on the cholinergic system
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PTGS2 antibodyPathways associated with anti-PTGS2 antibody
 Reference Product  PubMed Publications
 JUN antibody  >3171 publications with PTGS2 and JUN
 PLA2G4A antibody  >335 publications with PTGS2 and PLA2G4A
 TP53 antibody  >93 publications with PTGS2 and TP53
 CAV1 antibody  >18 publications with PTGS2 and CAV1
 MAPK14 antibody  >9 publications with PTGS2 and MAPK14
 PLA2G2A antibody  >9 publications with PTGS2 and PLA2G2A
 PLA2G5 antibody  >8 publications with PTGS2 and PLA2G5
 PLA2G10 antibody  >4 publications with PTGS2 and PLA2G10
 PLA2G1B antibody  >3 publications with PTGS2 and PLA2G1B
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 C20 Prostanoid Biosynthesis Pathway antibodies  C20 Prostanoid Biosynthesis Pathway Diagram
 C20 Prostanoid Biosynthesis Pathway antibodies  C20 Prostanoid Biosynthesis Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
Diseases associated with anti-PTGS2 antibodyOrgans/Tissues associated with anti-PTGS2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7369 publications with PTGS2 and Inflammation
 Carcinoma Antibodies  >3306 publications with PTGS2 and Carcinoma
 Nervous System Diseases Antibodies  >2839 publications with PTGS2 and Nervous System Diseases
 Colorectal Neoplasms Antibodies  >1806 publications with PTGS2 and Colorectal Neoplasms
 Adenocarcinoma Antibodies  >1564 publications with PTGS2 and Adenocarcinoma
 Skin Diseases Antibodies  >1305 publications with PTGS2 and Skin Diseases
 Lung Diseases Antibodies  >1166 publications with PTGS2 and Lung Diseases
 Edema Antibodies  >1042 publications with PTGS2 and Edema
 Colonic Neoplasms Antibodies  >908 publications with PTGS2 and Colonic Neoplasms
 Breast Neoplasms Antibodies  >827 publications with PTGS2 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5205 publications with PTGS2 and Blood
 Vascular Antibodies  >3450 publications with PTGS2 and Vascular
 Brain Antibodies  >2229 publications with PTGS2 and Brain
 Lung Antibodies  >1751 publications with PTGS2 and Lung
 Liver Antibodies  >1593 publications with PTGS2 and Liver
 Muscle Antibodies  >1498 publications with PTGS2 and Muscle
 Kidney Antibodies  >1361 publications with PTGS2 and Kidney
 Bone Antibodies  >1288 publications with PTGS2 and Bone
 Stomach Antibodies  >1285 publications with PTGS2 and Stomach
 Intestine Antibodies  >1141 publications with PTGS2 and Intestine
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