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| Product Name
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COX5B, Polyclonal Antibody
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| Also Known As
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COX5B Antibody
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| Product Synonym Names
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Cytochrome c oxidase polypeptide Vb; Cytochrome c oxidase subunit 5B; mitochondrial precursor; EC 1.9.3.1
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| OMIM
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123866
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| 3D Structure
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ModBase 3D Structure for P10606
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| Clonality
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Polyclonal
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| Isotype
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IgG
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| Host
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Rabbit
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| Species Reactivity
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Human, Mouse, Rat
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| Specificity
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COX5B antibody detects endogenous levels of total COX5B protein.
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| Purity/Purification
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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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| Form/Format
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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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| Reactivity Note
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Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)
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| Immunogen
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The antiserum was produced against synthesized peptide derived from internal of human COX5B.
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| Preparation and Storage
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Store at -20 degree C for 1 year
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| Other Notes
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Small volumes of anti-COX5B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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| Product Categories/Family for anti-COX5B antibody
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Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
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| Applications Tested/Suitable for anti-COX5B antibody
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Western Blot (WB), ELISA (EIA)
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| Application Notes for anti-COX5B antibody
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IHC: 1:50~1:100, ELISA: 1:20000
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| Testing Data of anti-COX5B antibody
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Peptide - +
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using COX5B antibody.
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TOP
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| NCBI/Uniprot data below describe general gene information for COX5B. It may not necessarily be applicable to this product. |
| NCBI GI #
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17017988
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| NCBI GeneID
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1329
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| NCBI Accession #
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NP_001853.2
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_001862.2
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[Other Products]
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| UniProt Primary Accession #
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P10606
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[Other Products]
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| UniProt Secondary Accession #
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Q53YB7; Q96J18; Q99610
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[Other Products]
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| UniProt Related Accession #
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P10606
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[Other Products]
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| Molecular Weight
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13,696 Da
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TOP
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| NCBI Official Full Name
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cytochrome c oxidase subunit 5B, mitochondrial
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| NCBI Official Synonym Full Names
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cytochrome c oxidase subunit Vb
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| NCBI Official Symbol
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COX5B
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[Similar Products]
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| NCBI Official Synonym Symbols
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COXVB
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[Similar Products]
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| NCBI Protein Information
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cytochrome c oxidase subunit 5B, mitochondrial; cytochrome c oxidase polypeptide VB, mitochondrial
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| UniProt Protein Name
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Cytochrome c oxidase subunit 5B, mitochondrial
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| UniProt Synonym Protein Names
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Cytochrome c oxidase polypeptide Vb
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| Protein Family
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Cytochrome c oxidase polypeptide
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| UniProt Gene Name
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COX5B
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[Similar Products]
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| UniProt Entry Name
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COX5B_HUMAN
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| NCBI Summary for COX5B
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Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. [provided by RefSeq, Jul 2008]
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| UniProt Comments for COX5B
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COX5B: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Belongs to the cytochrome c oxidase subunit 5B family.
Protein type: Mitochondrial; Energy Metabolism - oxidative phosphorylation; Oxidoreductase; EC 1.9.3.1
Chromosomal Location of Human Ortholog: 2q11.2
Cellular Component: mitochondrion; mitochondrial inner membrane
Molecular Function: cytochrome-c oxidase activity; metal ion binding
Biological Process: cellular metabolic process; respiratory gaseous exchange; transmembrane transport
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TOP
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Lomax M.I., Genomics 10:1-9(1991).
Bachman N.J., Arch. Biochem. Biophys. 333:152-162(1996).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
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| Research Articles on COX5B
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1. Transfected the A549 cells with COX Vb small interfering or shRNA and observed a significant reduction of their COX activity, oxygen consumption, ATP and ability to grow in soft agar and as poorly differentiated tumors in athymic mice.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Products associated with anti-COX5B antibody | Pathways associated with anti-COX5B antibody |
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| Diseases associated with anti-COX5B antibody | Organs/Tissues associated with anti-COX5B antibody |
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Antibody 
