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anti-CPN1 antibody :: Rabbit anti-Human, Mouse CPN1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7045345
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CPN1, Polyclonal Antibody

★Popular Item★
 Also Known As   

CPN1 Antibody

 Product Synonym Names    Carboxypeptidase N catalytic chain; CPN; Anaphylatoxin inactivator; Arginine carboxypeptidase; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit; Kininase-1; Lysine carboxypeptidase; Plasma carboxypeptidase B; Serum carboxypeptidase N; SCPN; CPN1; ACBP
 Product Gene Name   

anti-CPN1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    212070
 3D Structure    ModBase 3D Structure for P15169
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Carboxypeptidase N catalytic chain protein (C-250AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-18966
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CPN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CPN1 antibody

   Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
 Applications Tested/Suitable for anti-CPN1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-CPN1 antibody    Western blot
All lanes: CPN1 antibody at 6.19ug/ml
Lane 1: Mouse liver tissue
Lane 2: MCF7 whole cell lysate
Lane 3: HepG-2 whole cell lysate
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 52 kDa
Observed band size: 52 kDa

anti-CPN1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CPN1 antibody    Immunohistochemistry of paraffin-embedded human liver tissue using MBS7045345 at dilution 1:100
anti-CPN1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CPN1 antibody    Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7045345 at dilution 1:100
anti-CPN1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CPN1. It may not necessarily be applicable to this product.
 NCBI GI #    4503011
 NCBI GeneID    1369
 NCBI Accession #    NP_001299.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001308.2 [Other Products]
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 UniProt Primary Accession #    P15169 [Other Products]
 UniProt Secondary Accession #    B1AP59 [Other Products]
 UniProt Related Accession #    P15169 [Other Products]
 Molecular Weight    52,286 Da
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 NCBI Official Full Name    carboxypeptidase N catalytic chain
 NCBI Official Synonym Full Names    carboxypeptidase N subunit 1
 NCBI Official Symbol    CPN1 [Similar Products]
 NCBI Official Synonym Symbols   
CPN; SCPN
[Similar Products]
 NCBI Protein Information    carboxypeptidase N catalytic chain
 UniProt Protein Name    Carboxypeptidase N catalytic chain
 UniProt Synonym Protein Names   
Anaphylatoxin inactivator; Arginine carboxypeptidase; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit; Kininase-1; Lysine carboxypeptidase; Plasma carboxypeptidase B; Serum carboxypeptidase N; SCPN
 Protein Family    Carboxypeptidase
 UniProt Gene Name    CPN1 [Similar Products]
 UniProt Synonym Gene Names    ACBP; CPN; SCPN [Similar Products]
 UniProt Entry Name    CBPN_HUMAN
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 NCBI Summary for CPN1    Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CPN1    CPN1: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND). Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder. Belongs to the peptidase M14 family.

Protein type: Secreted; Protease; EC 3.4.17.3; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q24.2

Molecular Function: serine carboxypeptidase activity

Biological Process: peptide metabolic process; protein processing

Disease: Carboxypeptidase N Deficiency
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 Research Articles on CPN1    1. CPN binds to fibrinogen and is present in a fibrin clot prepared from plasma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CPN1 antibodyDiseases associated with anti-CPN1 antibody
 Products by Pathway  Pathway Diagram
 Insulin Processing Pathway antibodies  Insulin Processing Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >5 publications with CPN1 and Liver Diseases
 Heart Diseases Antibodies  >4 publications with CPN1 and Heart Diseases
 Inflammation Antibodies  >3 publications with CPN1 and Inflammation
 Brain Diseases Antibodies  >2 publications with CPN1 and Brain Diseases
 Cardiovascular Diseases Antibodies  >2 publications with CPN1 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >2 publications with CPN1 and Kidney Diseases
 Hypertension Antibodies  >1 publications with CPN1 and Hypertension
 Fatty Liver Antibodies  >1 publications with CPN1 and Fatty Liver
 Drug-Induced Liver Injury Antibodies  >1 publications with CPN1 and Drug-Induced Liver Injury
 Insulin Resistance Antibodies  >1 publications with CPN1 and Insulin Resistance
Organs/Tissues associated with anti-CPN1 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with CPN1 and Liver
 Blood Antibodies  >4 publications with CPN1 and Blood
 Skin Antibodies  >1 publications with CPN1 and Skin
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