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anti-CPT1A antibody :: Goat CPT1A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420742
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CPT1A, Polyclonal Antibody

 Also Known As   

Goat anti-CPT1A Antibody

 Product Synonym Names    CPT1A; carnitine palmitoyltransferase 1A (liver); CPT1; CPT1-L; L-CPT1; carnitine palmitoyltransferase 1A; carnitine palmitoyltransferase I; carnitine palmitoyltransferase I, liver; CPT1A antibody; carnitine palmitoyltransferase 1A (liver) antibody; CPT1 antibody; CPT1-L antibody; L-CPT1 antibody; carnitine palmitoyltransferase 1A antibody; carnitine palmitoyltransferase I antibody; carnitine palmitoyltransferase I; liver antibody
 Product Gene Name   

anti-CPT1A antibody

[Similar Products]
 Antibody/Peptide Pairs    CPT1A peptide (MBS426179) is used for blocking the activity of CPT1A antibody (MBS420742)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DPAQTVEQRL KLFK
 OMIM    255120
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-DPAQTVEQRLKLFK, from the internal region of the protein sequence according to NP_001867.2; NP_001027017.1.
 Epitope    Internal region
 Note    This antibody is expected to recognize both reported isoforms (NP_001867.2; NP_001027017.1) but is not expected to recognise CPT1B.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-CPT1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CPT1A antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CPT1A antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Immunohistochemistry: In paraffin embedded Human Kidney shows mitochindrial staining in PCT. Recommended concentration, 4-6ug/ml.
Western Blot: Approx 80kDa band observed in human liver lysates (calculated MW of 86.2kDa according to NP_001027017.1). Recommended concentration: 0.1-0.3ug/ml.
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 Western Blot (WB) of anti-CPT1A antibody    (0.1ug/ml) staining of human liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-CPT1A antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CPT1A antibody    (4ug/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-CPT1A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CPT1A. It may not necessarily be applicable to this product.
 NCBI GI #    73623030
 NCBI GeneID    1374
 NCBI Accession #    NP_001867.2 [Other Products]
 NCBI Related Accession #    NP_001027017.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001876.3 [Other Products]
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 UniProt Secondary Accession #    Q8TCU0; Q9BWK0 [Other Products]
 UniProt Related Accession #    P50416 [Other Products]
 Molecular Weight    86,239 Da
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 NCBI Official Full Name    carnitine O-palmitoyltransferase 1, liver isoform isoform 1
 NCBI Official Synonym Full Names    carnitine palmitoyltransferase 1A
 NCBI Official Symbol    CPT1A [Similar Products]
 NCBI Official Synonym Symbols   
CPT1; CPT1-L; L-CPT1
[Similar Products]
 NCBI Protein Information    carnitine O-palmitoyltransferase 1, liver isoform
 UniProt Protein Name    Carnitine O-palmitoyltransferase 1, liver isoform
 UniProt Synonym Protein Names   
Carnitine O-palmitoyltransferase I, liver isoform; CPT I; CPTI-L; Carnitine palmitoyltransferase 1A
 Protein Family    Carnitine O-palmitoyltransferase
 UniProt Gene Name    CPT1A [Similar Products]
 UniProt Synonym Gene Names    CPT1; CPT1-L; CPT I; CPTI-L [Similar Products]
 UniProt Entry Name    CPT1A_HUMAN
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 NCBI Summary for CPT1A    The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CPT1A    CPT1A: Belongs to the carnitine/choline acetyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Lipid Metabolism - fatty acid; EC 2.3.1.21; Mitochondrial; Transferase

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: integral to mitochondrial outer membrane; membrane; mitochondrial inner membrane; mitochondrial outer membrane; mitochondrion

Molecular Function: carnitine O-palmitoyltransferase activity; identical protein binding

Biological Process: carnitine metabolic process; carnitine shuttle; circadian rhythm; eating behavior; epithelial cell differentiation; fatty acid beta-oxidation; glucose metabolic process; long-chain fatty acid metabolic process; positive regulation of fatty acid beta-oxidation; protein homooligomerization; regulation of insulin secretion; response to drug; response to organic cyclic substance; triacylglycerol metabolic process

Disease: Carnitine Palmitoyltransferase I Deficiency
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 Research Articles on CPT1A    1. the structure of the regulatory domain of CPT1C was determined (residues Met1-Phe50) by NMR spectroscopy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CPT1A antibodyPathways associated with anti-CPT1A antibody
 Reference Product  PubMed Publications
 ACOX1 antibody  >23 publications with CPT1A and ACOX1
 PPARGC1A antibody  >13 publications with CPT1A and PPARGC1A
 LPL antibody  >13 publications with CPT1A and LPL
 PPARA antibody  >12 publications with CPT1A and PPARA
 ACSL1 antibody  >11 publications with CPT1A and ACSL1
 FABP1 antibody  >6 publications with CPT1A and FABP1
 EHHADH antibody  >4 publications with CPT1A and EHHADH
 ACSL5 antibody  >3 publications with CPT1A and ACSL5
 SLC25A20 antibody  >1 publications with CPT1A and SLC25A20
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
Diseases associated with anti-CPT1A antibodyOrgans/Tissues associated with anti-CPT1A antibody
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >125 publications with CPT1A and Fatty Liver
 Liver Diseases Antibodies  >50 publications with CPT1A and Liver Diseases
 Insulin Resistance Antibodies  >43 publications with CPT1A and Insulin Resistance
 Inflammation Antibodies  >24 publications with CPT1A and Inflammation
 Non-alcoholic Fatty Liver Disease Antibodies  >19 publications with CPT1A and Non-alcoholic Fatty Liver Disease
 Weight Gain Antibodies  >15 publications with CPT1A and Weight Gain
 Diabetes Mellitus Antibodies  >12 publications with CPT1A and Diabetes Mellitus
 Cardiovascular Diseases Antibodies  >11 publications with CPT1A and Cardiovascular Diseases
 Dyslipidemias Antibodies  >11 publications with CPT1A and Dyslipidemias
 Hepatitis Antibodies  >11 publications with CPT1A and Hepatitis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >157 publications with CPT1A and Liver
 Blood Antibodies  >83 publications with CPT1A and Blood
 Muscle Antibodies  >47 publications with CPT1A and Muscle
 Brain Antibodies  >23 publications with CPT1A and Brain
 Connective Tissue Antibodies  >18 publications with CPT1A and Connective Tissue
 Kidney Antibodies  >11 publications with CPT1A and Kidney
 Vascular Antibodies  >9 publications with CPT1A and Vascular
 Thyroid Antibodies  >5 publications with CPT1A and Thyroid
 Pancreas Antibodies  >5 publications with CPT1A and Pancreas
 Lung Antibodies  >4 publications with CPT1A and Lung
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