NP_001867.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
carnitine O-palmitoyltransferase 1, liver isoform isoform 1
NCBI Official Synonym Full Names
carnitine palmitoyltransferase 1A (liver)
NCBI Protein Information
carnitine O-palmitoyltransferase 1, liver isoform; CPT I; CPTI-L; OTTHUMP00000237196; OTTHUMP00000237197; OTTHUMP00000237552; carnitine palmitoyltransferase I, liver; carnitine O-palmitoyltransferase I, liver isoform
UniProt Protein Name
Carnitine O-palmitoyltransferase 1, liver isoform
UniProt Synonym Protein Names
Carnitine O-palmitoyltransferase I, liver isoform; CPT I; CPTI-L; Carnitine palmitoyltransferase 1A
UniProt Synonym Gene Names
UniProt Entry Name
CPT1A_HUMAN
NCBI Summary for CPT1A
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
UniProt Comments for CPT1A
CPT1A: Belongs to the carnitine/choline acetyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Transferase; Membrane protein, integral; EC 2.3.1.21; Mitochondrial; Lipid Metabolism - fatty acid
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component: mitochondrial outer membrane; membrane; mitochondrion; mitochondrial inner membrane; integral to mitochondrial outer membrane
Molecular Function: identical protein binding; carnitine O-palmitoyltransferase activity
Biological Process: circadian rhythm; response to drug; eating behavior; glucose metabolic process; long-chain fatty acid metabolic process; cellular lipid metabolic process; carnitine shuttle; response to organic cyclic substance; positive regulation of fatty acid beta-oxidation; triacylglycerol metabolic process; fatty acid beta-oxidation; epithelial cell differentiation; carnitine metabolic process; regulation of insulin secretion; protein homooligomerization
Disease: Carnitine Palmitoyltransferase I Deficiency
Research Articles on CPT1A
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Pathways associated with anti-CPT1A antibody
Diseases associated with anti-CPT1A antibody
Organs/Tissues associated with anti-CPT1A antibody
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