Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow CRBN rightarrow Polyclonal CRBN  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Sorbitol Dehydrogenase (SDH) ELISA Kit
 • Ob-R Antibody
 • gp120 (Clade C) Antibody
 • EGF R Antibody
 • Vinculin (VCL) Antibody
 • Treponema Pallidum (TP) PCR Kit
 • Estrogens ELISA Kit
 • IL-6R Antibody
 • RAGE Antibody
 • Von Willebrand Factor (Vwf) ELISA Kit
 • YWHAE Antibody
 • Monocyte Chemotactic Protein-4 (MCP 4) Recombinant Protein
 • prolactin soluble receptor Recombinant Protein
 • Neuroglobin (NGB) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-CRBN antibody :: Rabbit CRBN / Cereblon Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS249626
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CRBN / Cereblon, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-CRBN / Cereblon Antibody (C-Terminus) IHC-plus

 Product Synonym Names    Rabbit Polyclonal to Human CRBN / Cereblon; Human CRBN / Cereblon; Cereblon; MRT2; MRT2A; Protein x 0001; Protein cereblon
 Product Gene Name   

anti-CRBN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    607417
 3D Structure    ModBase 3D Structure for Q96SW2
Section Bar
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Mouse, Rat, Human
Section Bar
 Specificity    CRBN antibody is human, mouse and rat reactive. At least two isoforms of CRBN are known to exist; this antibody will detect both isoforms.
 Purity/Purification    Immunoaffinity purified
 Form/Format    PBS, 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
Section Bar
 Immunogen    CRBN / Cereblon antibody was raised against cRBN antibody was raised against a 16 amino acid peptide near the carboxy terminus of human CRBN.
 Immunogen Description    CRBN antibody was raised against a 16 amino acid peptide near the carboxy terminus of human CRBN.
 Immunogen Type    Synthetic peptide
 Antigen Modification    C-Terminus
 Target Species    Human
Section Bar
 Preparation and Storage    Long term: -20 degree C
Short term: 4 degree C
Avoid repeat freeze-thaw cycles
 Other Notes    Small volumes of anti-CRBN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-CRBN antibody

   Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.
 Applications Tested/Suitable for anti-CRBN antibody   

Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CRBN antibody    IF (20 ug/ml)
IHC-P (5 ug/ml)
WB (1 - 2 ug/ml)
ELISA (Optimal dilutions to be determined by researcher.)
Section Bar
 Immunohistochemistry (IHC) of anti-CRBN antibody    Immunohistochemistry of CRBN in rat testis tissue with CRBN antibody at 5 ug/mL.
anti-CRBN antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-CRBN antibody    Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)
anti-CRBN antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-CRBN antibody    Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
anti-CRBN antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunofluorescence (IF) of anti-CRBN antibody    Immunofluorescence of CRBN in rat testis tissue with CRBN antibody at 20 ug/mL.
anti-CRBN antibody Immunofluorescence (IF) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CRBN. It may not necessarily be applicable to this product.
 NCBI GI #    39545580
 NCBI GeneID    51185
 NCBI Accession #    NP_057386.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_016302.3 [Other Products]
Section Bar
 UniProt Primary Accession #    Q96SW2 [Other Products]
 UniProt Secondary Accession #    Q6AI62; Q6NVZ0; Q9UHW4; B2R6H4; C9IZA9; C9JAH6 [Other Products]
 UniProt Related Accession #    Q96SW2 [Other Products]
 Molecular Weight    50,475 Da
Table BarTOPTable Bar
 NCBI Official Full Name    protein cereblon isoform 1
 NCBI Official Synonym Full Names    cereblon
 NCBI Official Symbol    CRBN [Similar Products]
 NCBI Official Synonym Symbols   
MRT2; MRT2A
[Similar Products]
 NCBI Protein Information    protein cereblon
 UniProt Protein Name    Protein cereblon
 Protein Family    Protein cereblon
 UniProt Gene Name    CRBN [Similar Products]
 UniProt Entry Name    CRBN_HUMAN
Section Bar
 NCBI Summary for CRBN    This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Section Bar
 UniProt Comments for CRBN    CRBN: Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Defects in CRBN are the cause of mental retardation autosomal recessive type 2A (MRT2A). MRT2A patients display mild mental retardation with a standard IQ ranged from 50 to 70. IQ scores are lower in males than females. Developmental milestones are mildly delayed. There are no dysmorphic or autistic features. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the CRBN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 3p26.2

Cellular Component: cytoplasm; membrane; nucleolus; nucleus

Molecular Function: ATP-dependent peptidase activity; metal ion binding; protein binding

Biological Process: negative regulation of protein homooligomerization; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination

Disease: Mental Retardation, Autosomal Recessive 2
Table BarTOPTable Bar
 Research Articles on CRBN    1. Although abnormal CRBN function may be associated with intellectual disability disease onset, its cellular mechanism is still unclear. Here, we examine the role of CRBN in aggresome formation and cytoprotection.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-CRBN antibodyDiseases associated with anti-CRBN antibody
 Reference Product  PubMed Publications
 DDB1 antibody  >15 publications with CRBN and DDB1
 CUL4A antibody  >9 publications with CRBN and CUL4A
 RBX1 antibody  >4 publications with CRBN and RBX1
 DTL antibody  >1 publications with CRBN and DTL
 CUL4B antibody  >1 publications with CRBN and CUL4B
 Disease Name  Pubmed Publications
 Multiple Myeloma Antibodies  >43 publications with CRBN and Multiple Myeloma
 Cardiovascular Diseases Antibodies  >27 publications with CRBN and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >16 publications with CRBN and Nervous System Diseases
 Neurobehavioral Manifestations Antibodies  >14 publications with CRBN and Neurobehavioral Manifestations
 Mental Retardation, Autosomal Recessive 2 Antibodies  >8 publications with CRBN and Mental Retardation, Autosomal Recessive 2
 Abnormalities, Multiple Antibodies  >4 publications with CRBN and Abnormalities, Multiple
 Learning Disorders Antibodies  >3 publications with CRBN and Learning Disorders
 Disease Models, Animal Antibodies  >3 publications with CRBN and Disease Models, Animal
 Memory Disorders Antibodies  >2 publications with CRBN and Memory Disorders
 Abnormalities, Drug-Induced Antibodies  >2 publications with CRBN and Abnormalities, Drug-Induced
Organs/Tissues associated with anti-CRBN antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >19 publications with CRBN and Blood
 Brain Antibodies  >16 publications with CRBN and Brain
 Nerve Antibodies  >12 publications with CRBN and Nerve
 Bone Marrow Antibodies  >10 publications with CRBN and Bone Marrow
 Bone Antibodies  >10 publications with CRBN and Bone
 Heart Antibodies  >3 publications with CRBN and Heart
 Muscle Antibodies  >2 publications with CRBN and Muscle
 Liver Antibodies  >2 publications with CRBN and Liver
 Prostate Antibodies  >2 publications with CRBN and Prostate
 Embryonic Tissue Antibodies  >2 publications with CRBN and Embryonic Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions