AAI72737.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
265,494 Da
NCBI Official Full Name
CREB binding protein
NCBI Official Synonym Full Names
CREB binding protein
NCBI Official Synonym Symbols
CBP; KAT3A; AW558298; CBP/p300; p300/CBP [Similar Products]
NCBI Protein Information
CREB-binding protein
UniProt Protein Name
CREB-binding protein
UniProt Synonym Gene Names
UniProt Comments for CREBBP
CBP: a protein acetyltransferase that can transcriptionally activate histones. Acetylates the NCOA3 coactivator. Binds specifically to phosphorylated CREB1 and enhances its transcriptional activity toward cAMP-responsive genes. Methylation of the KIX domain by CARM1 blocks association with CREB, blocking CREB signaling, and activating the apoptotic response. Found in a complex containing NCOA2, NCOA3, IKKA, IKKB, and IKBKG. Probably part of a complex with HIF1A and EP300. Interacts with the C-terminal region of CITED4. The TAZ-type 1 domain interacts with HIF1A. Interacts with MAF, SRCAP, CARM1, ELF3, MLLT7/FOXO4, N4BP2, NCOA1, NCOA3, NCOA6, PCAF, PELP1, PML, SMAD1, SMAD2, SMAD3, SPIB and TRERF1. Interacts with HTLV-1 Tax, p30II, and HIV-1 Tat. Interacts with KLF1; the interaction results in acetylation of KLF1 and enhancement of its transcriptional activity. Interacts with ZCCHC12. Interacts with DAXX; the interaction is dependent on CBP sumoylation and results in suppression of the transcriptional activiy via recruitment of HDAC2 to DAAX. Interacts with MTDH. Interacts with NFATC4. Interacts with MAFG; the interaction acetylates MAFG in the basic region and stimulates NFE2 transcriptional activity through increasing its DNA-binding activity. Interacts with IRF2; the interaction acetylates IRF2 and regulates its activity on the H4 promoter. Interacts via its N-terminus with the C-terminus of SS18L1. Interacts with MECOM. Chromosomal aberrations involving CBP may be a cause of acute myeloid leukemias. Known translocation partners include MYST3, MLL, and MYST4. MYST3-CBP fusion proteins may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1), an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.
Protein type: Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 16 A1|16 2.4 cM
Cellular Component: cytoplasm; histone acetyltransferase complex; nuclear body; nuclear chromatin; nucleoplasm; nucleus; outer kinetochore of condensed chromosome; PML body; protein complex; RNA polymerase II transcription factor complex; transcription factor complex
Molecular Function: acetyltransferase activity; activating transcription factor binding; cAMP response element binding protein binding; chromatin binding; damaged DNA binding; DNA binding; DNA binding transcription factor activity; histone acetyltransferase activity; metal ion binding; MRF binding; p53 binding; peroxisome proliferator activated receptor binding; protein binding; protein domain specific binding; protein heterodimerization activity; SMAD binding; transcription coactivator activity; transcription cofactor activity; transcription factor binding; transferase activity; transferase activity, transferring acyl groups; zinc ion binding
Biological Process: cell proliferation; cellular response to UV; germ-line stem cell maintenance; histone acetylation; N-terminal peptidyl-lysine acetylation; negative regulation of interferon-beta biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of viral process; positive regulation of CREB transcription factor activity; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of gene expression; positive regulation of NIK/NF-kappaB signaling; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein amino acid acetylation; protein destabilization; regulation of transcription, DNA-templated; rhythmic process; transcription, DNA-dependent
Research Articles on CREBBP
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Pathways associated with anti-CREBBP antibody
Organs/Tissues associated with anti-CREBBP antibody
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