NP_853549.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,269 Da
NCBI Official Full Name
cAMP-responsive element modulator isoform 1
NCBI Official Synonym Full Names
cAMP responsive element modulator
NCBI Protein Information
cAMP-responsive element modulator
UniProt Protein Name
cAMP-responsive element modulator
UniProt Synonym Protein Names
Inducible cAMP early repressor; ICER
UniProt Synonym Gene Names
UniProt Entry Name
CREM_HUMAN
NCBI Summary for CREM
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]
UniProt Comments for CREM
CREM: a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. An important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative splice isoforms allow this protein to exert spatial and temporal specificity to cAMP responsiveness. Twentyeight alternatively spliced isoforms of the human protein have been described, with some of them functioning as activators and some as repressors of transcription.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 10p11.21
Molecular Function: protein binding
Biological Process: regulation of transcription, DNA-dependent; signal transduction
Research Articles on CREM
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Pathways associated with anti-CREM antibody
Diseases associated with anti-CREM antibody
Organs/Tissues associated with anti-CREM antibody
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