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anti-CRH antibody :: Rabbit CRH / CRF Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242157
Immunohistochemistry (IHC)
Unit / Price
0.25 mL  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CRH / CRF, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human CRH / CRF

 Product Synonym Names    Anti-CRH / CRF Antibody (C-Terminus) IHC-plus; CRH; CRF; Corticoliberin; Corticotropin-releasing factor; Human CRH; CRF
 Product Gene Name   

anti-CRH antibody

[Similar Products]
 Product Synonym Gene Name    CRF [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    122560
 3D Structure    ModBase 3D Structure for P06850
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, BSA, sodium azide.
 Concentration    0.2 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    A synthetic peptide from C-terminus of human CRF protein.
 Immunogen Type    Synthetic peptide
 Immunogen    CRH / CRF antibody was raised against a synthetic peptide from C-terminus of human CRF protein.
 Antigen Modification    C-Terminus
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 Preparation and Storage    Store at 2-8 degree C
 Other Notes    Small volumes of anti-CRH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CRH antibody

   Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 191-amino acid preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in CRH has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis.
 Product Categories/Family for anti-CRH antibody    Family: Hormone
 Applications Tested/Suitable for anti-CRH antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-CRH antibody    IHC-P (20 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-CRH antibody    Anti-CRH antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
anti-CRH antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CRH. It may not necessarily be applicable to this product.
 NCBI GI #    4503041
 NCBI GeneID    1392
 NCBI Accession #    NP_000747.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000756.2 [Other Products]
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 UniProt Primary Accession #    P06850 [Other Products]
 UniProt Secondary Accession #    B3KQS4 [Other Products]
 UniProt Related Accession #    P06850 [Other Products]
 Molecular Weight    21,422 Da
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 NCBI Official Full Name    corticoliberin preproprotein
 NCBI Official Synonym Full Names    corticotropin releasing hormone
 NCBI Official Symbol    CRH [Similar Products]
 NCBI Official Synonym Symbols   
CRF; CRH1
[Similar Products]
 NCBI Protein Information    corticoliberin; corticotropin-releasing factor
 UniProt Protein Name    Corticoliberin
 UniProt Synonym Protein Names   
Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone
 Protein Family    Corticoliberin
 UniProt Gene Name    CRH [Similar Products]
 UniProt Synonym Gene Names    CRF [Similar Products]
 UniProt Entry Name    CRF_HUMAN
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 NCBI Summary for CRH    Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010]
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 UniProt Comments for CRH    CRH: This hormone from hypothalamus regulates the release of corticotropin from pituitary gland. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8q13

Cellular Component: extracellular space; cytoplasm; extracellular region; perikaryon

Molecular Function: corticotropin-releasing hormone receptor 1 binding; neuropeptide hormone activity; protein binding; hormone activity; corticotropin-releasing hormone receptor 2 binding; receptor binding; adrenocorticotropin-releasing hormone activity

Biological Process: diterpenoid metabolic process; synaptic transmission, dopaminergic; negative regulation of circadian sleep/wake cycle, REM sleep; positive regulation of cortisol secretion; hypothalamus development; induction of apoptosis by hormones; response to pain; female pregnancy; signal transduction; positive regulation of adrenocorticotropic hormone secretion; synaptic transmission; negative regulation of luteinizing hormone secretion; learning and/or memory; positive regulation of cell proliferation; positive regulation of cAMP biosynthetic process; feeding behavior; negative regulation of blood pressure; parturition; response to electrical stimulus; inflammatory response; associative learning; response to corticosterone stimulus; response to drug; adrenal gland development; response to ether; response to ethanol; long-term memory; response to estrogen stimulus; ion homeostasis; regulation of serotonin secretion; negative regulation of epinephrine secretion; positive regulation of protein amino acid phosphorylation; glucocorticoid biosynthetic process; lung development

Disease: Acth Deficiency, Isolated
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 Research Articles on CRH    1. This review focuses on the CRF receptor, a stress-related peptide implicated in diverse psychiatric and medical disorders that are more prevalent in females in diverse psychiatric and medical disorders that are more prevalent in females.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CRH antibodyPathways associated with anti-CRH antibody
 Reference Product  PubMed Publications
 POMC antibody  >2211 publications with CRH and POMC
 AVP antibody  >534 publications with CRH and AVP
 NPY antibody  >181 publications with CRH and NPY
 CRHR1 antibody  >176 publications with CRH and CRHR1
 GHRH antibody  >156 publications with CRH and GHRH
 UCN antibody  >95 publications with CRH and UCN
 CRHR2 antibody  >79 publications with CRH and CRHR2
 ADCYAP1 antibody  >15 publications with CRH and ADCYAP1
 MC4R antibody  >12 publications with CRH and MC4R
 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
Diseases associated with anti-CRH antibodyOrgans/Tissues associated with anti-CRH antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >675 publications with CRH and Mental Disorders
 Nervous System Diseases Antibodies  >650 publications with CRH and Nervous System Diseases
 Brain Diseases Antibodies  >516 publications with CRH and Brain Diseases
 Cushing Syndrome Antibodies  >371 publications with CRH and Cushing Syndrome
 Depressive Disorder Antibodies  >328 publications with CRH and Depressive Disorder
 Inflammation Antibodies  >253 publications with CRH and Inflammation
 Anxiety Disorders Antibodies  >234 publications with CRH and Anxiety Disorders
 Necrosis Antibodies  >133 publications with CRH and Necrosis
 Hypertension Antibodies  >120 publications with CRH and Hypertension
 Pain Antibodies  >100 publications with CRH and Pain
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3247 publications with CRH and Brain
 Adrenal Gland Antibodies  >788 publications with CRH and Adrenal Gland
 Placenta Antibodies  >280 publications with CRH and Placenta
 Muscle Antibodies  >152 publications with CRH and Muscle
 Embryonic Tissue Antibodies  >127 publications with CRH and Embryonic Tissue
 Uterus Antibodies  >120 publications with CRH and Uterus
 Connective Tissue Antibodies  >47 publications with CRH and Connective Tissue
 Pancreas Antibodies  >19 publications with CRH and Pancreas
 Uncharacterized Tissue Antibodies  >1 publications with CRH and Uncharacterized Tissue
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