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anti-CRHR1 antibody :: Goat CRHR1/CRF-R Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421140 anti-CRHR1 antibody
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CRHR1/CRF-R, Polyclonal Antibody

 Also Known As   

Goat anti-CRHR1/CRF-R (aa 250 - 263) Antibody

 Product Synonym Names    Goat Anti-CRHR1 / CRF-R (aa 107 - 117) Antibody; CRHR1; CRF-R; corticotropin releasing hormone receptor 1; CRF1; CRFR1; CRH-R1h; CRHR; CRHR1f; corticotropin releasing hormone receptor variant 1h; seven transmembrane helix receptor; CRHR1 antibody; CRF-R antibody; corticotropin releasing hormone receptor 1 antibody; CRF1 antibody; CRFR1 antibody; CRH-R1h antibody; CRHR antibody; CRHR1f antibody; corticotropin releasing hormone receptor variant 1h antibody; seven transmembrane helix receptor antibody; CRHR1 / CRF-R (aa 250 - 263)
 Product Gene Name   

anti-CRHR1 antibody

[Similar Products]
 Product Synonym Gene Name    CRF-R [Similar Products]
 Antibody/Peptide Pairs    CRHR1 / CRF-R peptide (MBS428066) is used for blocking the activity of CRHR1/CRF-R antibody (MBS421140)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    KLYYDNEKCW FGKR
 OMIM    122561
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow, Sheep
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence KLYYDNEKCWFGKR, from the internal region of the protein sequence according to NP_004373.2.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-CRHR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CRHR1 antibody   

Peptide ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC)

 Application Notes for anti-CRHR1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Immunohistochemistry: This product is successfully used in immunohistochemistry on mouse brain.
Western Blot: Preliminary experiments in human colon, duodenum and placenta lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
Immunofluorescence: This product is successfully used in immunofluoresence on mouse brain.
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NCBI/Uniprot data below describe general gene information for CRHR1. It may not necessarily be applicable to this product.
 NCBI GI #    19923245
 NCBI GeneID    1394
 NCBI Accession #    NP_004373.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004382.4 [Other Products]
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 UniProt Secondary Accession #    Q13008; Q4QRJ1; Q9UK64; B4DIE9 [Other Products]
 UniProt Related Accession #    P34998 [Other Products]
 Molecular Weight    28,122 Da
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 NCBI Official Full Name    corticotropin-releasing factor receptor 1 isoform 2
 NCBI Official Synonym Full Names    corticotropin releasing hormone receptor 1
 NCBI Official Symbol    CRHR1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    corticotropin-releasing factor receptor 1
 UniProt Protein Name    Corticotropin-releasing factor receptor 1
 UniProt Synonym Protein Names   
Corticotropin-releasing hormone receptor 1; CRH-R-1; CRH-R1
 Protein Family    Corticotropin-releasing factor receptor
 UniProt Gene Name    CRHR1 [Similar Products]
 UniProt Synonym Gene Names    CRFR; CRFR1; CRHR; CRF-R-1; CRF-R1; CRFR-1; CRH-R-1; CRH-R1 [Similar Products]
 UniProt Entry Name    CRFR1_HUMAN
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 NCBI Summary for CRHR1    This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Readthrough transcription also exists between this gene and upstream GeneID:401884 (ADP-ribosylation factor 3 pseudogene), and the readthrough transcripts encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Dec 2014]
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 UniProt Comments for CRHR1    CRF-R1: a G-protein coupled receptor that specifically binds corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. Four splice-variant isoforms have been described.

Protein type: Receptor, GPCR; GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: endosome; integral to membrane; integral to plasma membrane; intrinsic to plasma membrane; plasma membrane

Molecular Function: corticotrophin-releasing factor receptor activity; protein binding

Biological Process: adenylate cyclase activation; adrenocorticotropin hormone secretion; cell surface receptor linked signal transduction; female pregnancy; immune response; parturition
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 Research Articles on CRHR1    1. The results revealed that changes in depressive symptoms over time depended on both intervention group and genotypes (5-HTTLPR and CRHR1).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CRHR1 antibodyPathways associated with anti-CRHR1 antibody
 Reference Product  PubMed Publications
 CRH antibody  >208 publications with CRHR1 and CRH
 POMC antibody  >38 publications with CRHR1 and POMC
 CRHBP antibody  >21 publications with CRHR1 and CRHBP
 UCN antibody  >21 publications with CRHR1 and UCN
 UCN2 antibody  >9 publications with CRHR1 and UCN2
 CREB1 antibody  >2 publications with CRHR1 and CREB1
 KCNMA1 antibody  >1 publications with CRHR1 and KCNMA1
 SLC2A1 antibody  >1 publications with CRHR1 and SLC2A1
 DLG1 antibody  >1 publications with CRHR1 and DLG1
 YY1 antibody  >1 publications with CRHR1 and YY1
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Organs/Tissues associated with anti-CRHR1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >180 publications with CRHR1 and Brain
 Embryonic Tissue Antibodies  >5 publications with CRHR1 and Embryonic Tissue
 Ovary Antibodies  >3 publications with CRHR1 and Ovary
 Eye Antibodies  >2 publications with CRHR1 and Eye
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