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anti-TDGF1 antibody :: Goat CRIPTO Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421778
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CRIPTO (TDGF1), Polyclonal Antibody

 Also Known As   

Goat anti-CRIPTO Antibody

 Product Synonym Names    TDGF1; teratocarcinoma-derived growth factor 1; CR; CRGF; CRIPTO; Cripto-1; -; TDGF1 antibody; teratocarcinoma-derived growth factor 1 antibody; CR antibody; CRGF antibody; CRIPTO antibody; Cripto-1 antibody
 Product Gene Name   

anti-TDGF1 antibody

[Similar Products]
 Product Synonym Gene Name    CRIPTO [Similar Products]
 Antibody/Peptide Pairs    CRIPTO peptide (MBS425217) is used for blocking the activity of CRIPTO antibody (MBS421778)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    YGRNCEHDVR KEN
 OMIM    187395
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence YGRNCEHDVRKEN, from the internal region of the protein sequence according to NP_003203.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-TDGF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TDGF1 antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-TDGF1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Immunohistochemistry: In paraffin embedded Human Placenta shows stainng assocated with nuclei in some trophoblasts and weak cytoplasm staining in cytotrophoblasts. Recommended concentration, 3-5ug/ml.
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 Immunohistochemistry (IHC) of anti-TDGF1 antibody    (3.8ug/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-TDGF1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TDGF1. It may not necessarily be applicable to this product.
 NCBI GI #    4507425
 NCBI GeneID    6997
 NCBI Accession #    NP_003203.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003212.3 [Other Products]
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 UniProt Secondary Accession #    Q8TCC1 [Other Products]
 UniProt Related Accession #    P13385 [Other Products]
 Molecular Weight    21,169 Da
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 NCBI Official Full Name    teratocarcinoma-derived growth factor 1 isoform 1
 NCBI Official Synonym Full Names    teratocarcinoma-derived growth factor 1
 NCBI Official Symbol    TDGF1 [Similar Products]
 NCBI Official Synonym Symbols   
CR; CRGF; CRIPTO
[Similar Products]
 NCBI Protein Information    teratocarcinoma-derived growth factor 1
 UniProt Protein Name    Teratocarcinoma-derived growth factor 1
 UniProt Synonym Protein Names   
Cripto-1 growth factor; CRGF; Epidermal growth factor-like cripto protein CR1
 Protein Family    Teratocarcinoma-derived growth factor
 UniProt Gene Name    TDGF1 [Similar Products]
 UniProt Synonym Gene Names    CRIPTO; CRGF [Similar Products]
 UniProt Entry Name    TDGF1_HUMAN
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 NCBI Summary for TDGF1    This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
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 UniProt Comments for TDGF1    TDGF1: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Interacts with the activin type-1 receptor ACVR1B. Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.

Protein type: Cell cycle regulation; Membrane protein, GPI anchor; Membrane protein, peripheral; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: apical plasma membrane; cell surface; extracellular space; extrinsic to plasma membrane; lipid raft; plasma membrane

Molecular Function: growth factor activity; protein binding; receptor binding

Biological Process: activation of MAPK activity; cell differentiation; cell migration during sprouting angiogenesis; determination of anterior/posterior axis, embryo; embryonic development; epidermal growth factor receptor signaling pathway; heart development; mammary gland development; morphogenesis of a branching structure; negative regulation of apoptosis; peptidyl-serine phosphorylation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of signal transduction; somatic stem cell maintenance
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 Research Articles on TDGF1    1. these findings suggest a novel molecular network, involving CRIPTO, AKT, and FGFR signaling, in favor of the emergence of mesenchymal-like cancer cells during the development of aggressive prostate tumors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TDGF1 antibodyPathways associated with anti-TDGF1 antibody
 Reference Product  PubMed Publications
 NODAL antibody  >97 publications with TDGF1 and NODAL
 SMAD2 antibody  >31 publications with TDGF1 and SMAD2
 NANOG antibody  >31 publications with TDGF1 and NANOG
 ACVR1B antibody  >23 publications with TDGF1 and ACVR1B
 GDF3 antibody  >12 publications with TDGF1 and GDF3
 SOX2 antibody  >11 publications with TDGF1 and SOX2
 ACVR1C antibody  >5 publications with TDGF1 and ACVR1C
 ACVR2A antibody  >3 publications with TDGF1 and ACVR2A
 ACVR2B antibody  >1 publications with TDGF1 and ACVR2B
 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Glypican 1 Network Pathway antibodies  Glypican 1 Network Pathway Diagram
 POU5F1 (OCT4), SOX2, NANOG Activate Genes Related To Proliferation Pathway antibodies  POU5F1 (OCT4), SOX2, NANOG Activate Genes Related To Proliferation Pathway Diagram
 Regulation Of Signaling By NODAL Pathway antibodies  Regulation Of Signaling By NODAL Pathway Diagram
 Signaling By NODAL Pathway antibodies  Signaling By NODAL Pathway Diagram
 Transcriptional Regulation Of Pluripotent Stem Cells Pathway antibodies  Transcriptional Regulation Of Pluripotent Stem Cells Pathway Diagram
Diseases associated with anti-TDGF1 antibodyOrgans/Tissues associated with anti-TDGF1 antibody
 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >33 publications with TDGF1 and Skin Diseases
 Neoplasm Metastasis Antibodies  >23 publications with TDGF1 and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >22 publications with TDGF1 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >15 publications with TDGF1 and Neoplasms, Experimental
 Genital Diseases, Female Antibodies  >13 publications with TDGF1 and Genital Diseases, Female
 Nervous System Diseases Antibodies  >12 publications with TDGF1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >9 publications with TDGF1 and Disease Models, Animal
 Liver Diseases Antibodies  >9 publications with TDGF1 and Liver Diseases
 Holoprosencephaly Antibodies  >9 publications with TDGF1 and Holoprosencephaly
 Musculoskeletal Abnormalities Antibodies  >7 publications with TDGF1 and Musculoskeletal Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >66 publications with TDGF1 and Embryonic Tissue
 Muscle Antibodies  >24 publications with TDGF1 and Muscle
 Brain Antibodies  >13 publications with TDGF1 and Brain
 Liver Antibodies  >12 publications with TDGF1 and Liver
 Uterus Antibodies  >7 publications with TDGF1 and Uterus
 Testis Antibodies  >7 publications with TDGF1 and Testis
 Prostate Antibodies  >5 publications with TDGF1 and Prostate
 Kidney Antibodies  >4 publications with TDGF1 and Kidney
 Intestine Antibodies  >4 publications with TDGF1 and Intestine
 Spleen Antibodies  >3 publications with TDGF1 and Spleen
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