NP_003203.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,169 Da
NCBI Official Full Name
teratocarcinoma-derived growth factor 1 isoform 1
NCBI Official Synonym Full Names
teratocarcinoma-derived growth factor 1
NCBI Protein Information
teratocarcinoma-derived growth factor 1
UniProt Protein Name
Teratocarcinoma-derived growth factor 1
UniProt Synonym Protein Names
Cripto-1 growth factor; CRGF; Epidermal growth factor-like cripto protein CR1
UniProt Synonym Gene Names
UniProt Entry Name
TDGF1_HUMAN
NCBI Summary for TDGF1
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
UniProt Comments for TDGF1
TDGF1: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Interacts with the activin type-1 receptor ACVR1B. Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.
Protein type: Cell cycle regulation; Membrane protein, GPI anchor; Membrane protein, peripheral; Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: apical plasma membrane; cell surface; extracellular space; extrinsic to plasma membrane; lipid raft; plasma membrane
Molecular Function: growth factor activity; protein binding; receptor binding
Biological Process: activation of MAPK activity; cell differentiation; cell migration during sprouting angiogenesis; determination of anterior/posterior axis, embryo; embryonic development; epidermal growth factor receptor signaling pathway; heart development; mammary gland development; morphogenesis of a branching structure; negative regulation of apoptosis; peptidyl-serine phosphorylation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of signal transduction; somatic stem cell maintenance
Research Articles on TDGF1
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Products associated with anti-TDGF1 antibody
Pathways associated with anti-TDGF1 antibody
Diseases associated with anti-TDGF1 antibody
Organs/Tissues associated with anti-TDGF1 antibody
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