Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow CRKL rightarrow Polyclonal CRKL  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • MTOR-S2448 Antibody
 • Choline dehydrogenase, mitochondrial (CHDH) ELISA Kit
 • Interleukin 1beta (IL-1beta) ELISA Kit
 • L1 Cell Adhesion Molecule (L1CAM) ELISA Kit
 • Macrophage Stimulating Protein (MSP) Antibody
 • Brain Natriuretic Peptide (BNP) ELISA Kit
 • Dopamine Receptor D5 (DRD5) ELISA Kit
 • ACSM5 Antibody
 • GCN2 (EIF2AK4) Antibody
 • D130043K22Rik Antibody
 • Soluble Cluster of Differentiation 80 (SCD80) ELISA Kit
 • Primary amine oxidase, lung isozyme, partial (AOC3) Recombinant Protein
 • Fusion glycoprotein F0 Recombinant Protein
 • Streptolysin (slo) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-CRKL antibody :: Rabbit CRKL Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2525825
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CRKL, Polyclonal Antibody

 Also Known As   

CRKL Polyclonal Antibody

 Product Gene Name   

anti-CRKL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    602007
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Purity/Purification    Antigen affinity purification
 Concentration    2.3mg/mL (lot specific)
Section Bar
 Immunogen    Synthetic peptide of human CRKL
 Calculated Molecular Weight: 34kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Section Bar
 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-CRKL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-CRKL antibody

   This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
 Applications Tested/Suitable for anti-CRKL antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CRKL antibody    WB: 1:500-1:2000
IHC: 1:25-1:100
Section Bar
 Western Blot (WB) of anti-CRKL antibody    Western blot analysis of Lovo, Raji and A172 cell, using CRKL Polyclonal Antibody at dilution of 1:600
anti-CRKL antibody Western Blot (WB) (WB) image
Section Bar
 Immunohistochemistry (IHC) of anti-CRKL antibody    Immunohistochemistry of Human thyroid cancer using CRKL Polyclonal Antibody at dilution of 1:25
anti-CRKL antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-CRKL antibody    Immunohistochemistry of Human gastric cancer using CRKL Polyclonal Antibody at dilution of 1:25
anti-CRKL antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CRKL. It may not necessarily be applicable to this product.
 NCBI GI #    4885153
 NCBI GeneID    1399
 NCBI Accession #    NP_005198.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005207.3 [Other Products]
Section Bar
 UniProt Secondary Accession #    A8KA44; D3DX35 [Other Products]
 UniProt Related Accession #    P46109 [Other Products]
 Molecular Weight    34kDa
Table BarTOPTable Bar
 NCBI Official Full Name    crk-like protein
 NCBI Official Synonym Full Names    v-crk avian sarcoma virus CT10 oncogene homolog-like
 NCBI Official Symbol    CRKL [Similar Products]
 NCBI Protein Information    crk-like protein
 UniProt Protein Name    Crk-like protein
 Protein Family    Crk-like protein
 UniProt Gene Name    CRKL [Similar Products]
 UniProt Entry Name    CRKL_HUMAN
Section Bar
 NCBI Summary for CRKL    This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
Section Bar
 UniProt Comments for CRKL    CRKL: an oncogenic adaptor protein with an SH2-SH3-SH3 domain structure. Plays a specific role in integrin-induced migration as a downstream mediator of Src. Activates the RAS and Jnk signaling pathways. Transforms fibroblasts in a RAS-dependent fashion. A substrate of BCR-ABL and plays a role in fibroblast transformation by BCR-ABL.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: cytosol; endosome

Molecular Function: protein binding; signal transducer activity; SH3/SH2 adaptor activity

Biological Process: anterior/posterior pattern formation; blood vessel development; organ morphogenesis; nerve growth factor receptor signaling pathway; thymus development; activation of MAPKK activity; heart development; Ras protein signal transduction; JNK cascade; parathyroid gland development
Table BarTOPTable Bar
 Research Articles on CRKL    1. results suggest that CRKL has the ability to regulate colon cancer malignancy and CRKL has the potential to serve as a diagnosis and prognosis marker and a therapy target of colon cancer
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-CRKL antibodyPathways associated with anti-CRKL antibody
 Reference Product  PubMed Publications
 BCR antibody  >161 publications with CRKL and BCR
 CBL antibody  >70 publications with CRKL and CBL
 ABL1 antibody  >10 publications with CRKL and ABL1
 BCAR1 antibody  >9 publications with CRKL and BCAR1
 PXN antibody  >9 publications with CRKL and PXN
 GAB2 antibody  >7 publications with CRKL and GAB2
 EPOR antibody  >6 publications with CRKL and EPOR
 CBLB antibody  >2 publications with CRKL and CBLB
 MAP4K1 antibody  >1 publications with CRKL and MAP4K1
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
Diseases associated with anti-CRKL antibodyOrgans/Tissues associated with anti-CRKL antibody
 Disease Name  Pubmed Publications
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies  >87 publications with CRKL and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
 Leukemia, Myeloid, Acute Antibodies  >13 publications with CRKL and Leukemia, Myeloid, Acute
 Lung Neoplasms Antibodies  >13 publications with CRKL and Lung Neoplasms
 Disease Models, Animal Antibodies  >12 publications with CRKL and Disease Models, Animal
 Craniofacial Abnormalities Antibodies  >12 publications with CRKL and Craniofacial Abnormalities
 DiGeorge Syndrome Antibodies  >12 publications with CRKL and DiGeorge Syndrome
 Breast Neoplasms Antibodies  >8 publications with CRKL and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >7 publications with CRKL and Neoplasms, Experimental
 Inflammation Antibodies  >6 publications with CRKL and Inflammation
 Skin Diseases Antibodies  >5 publications with CRKL and Skin Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >101 publications with CRKL and Blood
 Bone Antibodies  >26 publications with CRKL and Bone
 Bone Marrow Antibodies  >22 publications with CRKL and Bone Marrow
 Lung Antibodies  >20 publications with CRKL and Lung
 Nerve Antibodies  >20 publications with CRKL and Nerve
 Brain Antibodies  >19 publications with CRKL and Brain
 Heart Antibodies  >13 publications with CRKL and Heart
 Embryonic Tissue Antibodies  >12 publications with CRKL and Embryonic Tissue
 Lymph Node Antibodies  >8 publications with CRKL and Lymph Node
 Lymph Antibodies  >8 publications with CRKL and Lymph
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions