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anti-CRTC1 antibody :: Rabbit anti-Human CRTC1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7050538
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CRTC1, Polyclonal Antibody

★Popular Item★
 Also Known As   

CRTC1 Antibody

 Product Synonym Names    CREB-regulated transcription coactivator 1; Mucoepidermoid carcinoma translocated protein 1; Transducer of regulated cAMP response element-binding protein 1; TORC-1; Transducer of CREB protein 1; CRTC1
 Product Gene Name   

anti-CRTC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AY360171 mRNA
 3D Structure    ModBase 3D Structure for Q6UUV9
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human CREB-regulated transcription coactivator 1 protein (1-248AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46269 / sc-46270 / sc-67146
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CRTC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CRTC1 antibody

   Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
 Applications Tested/Suitable for anti-CRTC1 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-CRTC1 antibody    IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Immunohistochemistry (IHC) of anti-CRTC1 antibody    Immunohistochemistry of paraffin-embedded human placenta tissue using MBS7050538 at dilution of 1:100
anti-CRTC1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-CRTC1 antibody    Immunofluorescent analysis of HepG2 cells using MBS7050538 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-CRTC1 antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-CRTC1 antibody    Western Blot
Positive WB detected in: A549 whole cell lysate,Hela whole cell lysate,HEK293 whole cell lysate
All lanes: CRTC1 antibody at 3.5ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 68,69,63 KDa
Observed band size: 68 KDa

anti-CRTC1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CRTC1. It may not necessarily be applicable to this product.
 NCBI GI #    148596988
 NCBI GeneID    23373
 NCBI Accession #    NP_001091952.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001098482.1 [Other Products]
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 UniProt Primary Accession #    Q6UUV9 [Other Products]
 UniProt Secondary Accession #    O75114; Q6Y3A3; Q7LDZ2; Q8IUL3; Q8IZ34; Q8IZL1; Q8N6W3; Q96AI8; Q9H801; A6NMG5 [Other Products]
 UniProt Related Accession #    Q6UUV9 [Other Products]
 Molecular Weight    62,530 Da
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 NCBI Official Full Name    CREB-regulated transcription coactivator 1 isoform 3
 NCBI Official Synonym Full Names    CREB regulated transcription coactivator 1
 NCBI Official Symbol    CRTC1 [Similar Products]
 NCBI Official Synonym Symbols   
MECT1; TORC1; TORC-1; WAMTP1
[Similar Products]
 NCBI Protein Information    CREB-regulated transcription coactivator 1
 UniProt Protein Name    CREB-regulated transcription coactivator 1
 UniProt Synonym Protein Names   
Mucoepidermoid carcinoma translocated protein 1; Transducer of regulated cAMP response element-binding protein 1; TORC-1; Transducer of CREB protein 1
 Protein Family    CREB-regulated transcription coactivator
 UniProt Gene Name    CRTC1 [Similar Products]
 UniProt Synonym Gene Names    TORC-1; Transducer of CREB protein 1 [Similar Products]
 UniProt Entry Name    CRTC1_HUMAN
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 UniProt Comments for CRTC1    TORC1: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long- term potentiation (L-LTP) maintenance at the Schaffer collateral- CA1 synapses. May be required for dendritic growth of developing cortical neurons. Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax. Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney. Belongs to the TORC family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: cytoplasm; nucleoplasm; nucleus; plasma membrane

Molecular Function: cAMP response element binding protein binding; protein binding

Biological Process: activation of CREB transcription factor; entrainment of circadian clock by photoperiod; positive regulation of transcription from RNA polymerase II promoter
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 Research Articles on CRTC1    1. DNA methylation levels within two distinct promoter regions of the CREB regulated transcription coactivator 1 gene were decreased in human hippocampus affected by Alzheimer disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CRTC1 antibodyPathways associated with anti-CRTC1 antibody
 Reference Product  PubMed Publications
 MAML2 antibody  >59 publications with CRTC1 and MAML2
 JUN antibody  >24 publications with CRTC1 and JUN
 CREB1 antibody  >15 publications with CRTC1 and CREB1
 FOS antibody  >7 publications with CRTC1 and FOS
 SIK2 antibody  >3 publications with CRTC1 and SIK2
 ATF1 antibody  >3 publications with CRTC1 and ATF1
 XBP1 antibody  >1 publications with CRTC1 and XBP1
 CREM antibody  >1 publications with CRTC1 and CREM
 Products by Pathway  Pathway Diagram
 BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies  BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
 Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway antibodies  Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Circadian Rythm Related Genes Pathway antibodies  Circadian Rythm Related Genes Pathway Diagram
 Endoderm Differentiation Pathway antibodies  Endoderm Differentiation Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Mesodermal Commitment Pathway antibodies  Mesodermal Commitment Pathway Diagram
 Mitochondrial Biogenesis Pathway antibodies  Mitochondrial Biogenesis Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram
Diseases associated with anti-CRTC1 antibodyOrgans/Tissues associated with anti-CRTC1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >27 publications with CRTC1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >27 publications with CRTC1 and Disease Models, Animal
 Chromosome Aberrations Antibodies  >16 publications with CRTC1 and Chromosome Aberrations
 Mental Disorders Antibodies  >16 publications with CRTC1 and Mental Disorders
 Kidney Diseases Antibodies  >13 publications with CRTC1 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >11 publications with CRTC1 and Cardiovascular Diseases
 Lung Diseases Antibodies  >11 publications with CRTC1 and Lung Diseases
 Nervous System Malformations Antibodies  >8 publications with CRTC1 and Nervous System Malformations
 Memory Disorders Antibodies  >6 publications with CRTC1 and Memory Disorders
 Learning Disorders Antibodies  >6 publications with CRTC1 and Learning Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >62 publications with CRTC1 and Brain
 Blood Antibodies  >23 publications with CRTC1 and Blood
 Lung Antibodies  >17 publications with CRTC1 and Lung
 Kidney Antibodies  >16 publications with CRTC1 and Kidney
 Nerve Antibodies  >12 publications with CRTC1 and Nerve
 Liver Antibodies  >11 publications with CRTC1 and Liver
 Heart Antibodies  >8 publications with CRTC1 and Heart
 Pancreas Antibodies  >7 publications with CRTC1 and Pancreas
 Bone Antibodies  >6 publications with CRTC1 and Bone
 Embryonic Tissue Antibodies  >6 publications with CRTC1 and Embryonic Tissue
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