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anti-CRTC2 antibody :: Goat CRTC2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422613
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CRTC2, Polyclonal Antibody

 Also Known As   

Goat anti-CRTC2 Antibody

 Product Synonym Names    Goat Anti-CRTC2 / TORC2 (aa 83-96) Antibody; Crtc2; CREB regulated transcription coactivator 2; 4632407F12Rik; Torc2; OTTMUSP00000023505; transducer of regulated cAMP response element-binding protein (CREB) 2; Crtc2 antibody; CREB regulated transcription coactivator 2 antibody; 4632407F12Rik antibody; Torc2 antibody; OTTMUSP00000023505 antibody; transducer of regulated cAMP response element-binding protein (CREB) 2 antibody; CRTC2
 Product Gene Name   

anti-CRTC2 antibody

[Similar Products]
 Antibody/Peptide Pairs    CRTC2 peptide (MBS428267) is used for blocking the activity of CRTC2 antibody (MBS422613)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DPAVEDSFRS DRLQ
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-DPAVEDSFRSDRLQ, from the C Terminus of the protein sequence according to NP_083157.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-CRTC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CRTC2 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-CRTC2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 90kDa band observed in lysates of cell line Jurkat (calculated MW of 73.2kDa according to NP_083157.1). The observed molecular weight corresponds to earlier findings with different antibodies from other commercial sources. Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-CRTC2 antibody    (1ug/ml) staining of Jurkat lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-CRTC2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CRTC2. It may not necessarily be applicable to this product.
 NCBI GI #    58037361
 NCBI GeneID    74343
 NCBI Accession #    NP_083157.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_028881.2 [Other Products]
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 UniProt Secondary Accession #    Q3TA52; Q8BH09 [Other Products]
 UniProt Related Accession #    Q3U182 [Other Products]
 Molecular Weight    73,216 Da
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 NCBI Official Full Name    CREB-regulated transcription coactivator 2
 NCBI Official Synonym Full Names    CREB regulated transcription coactivator 2
 NCBI Official Symbol    Crtc2 [Similar Products]
 NCBI Official Synonym Symbols   
Torc2; mTORC2; 4632407F12Rik
[Similar Products]
 NCBI Protein Information    CREB-regulated transcription coactivator 2
 UniProt Protein Name    CREB-regulated transcription coactivator 2
 UniProt Synonym Protein Names   
Transducer of regulated cAMP response element-binding protein 2; TORC-2; Transducer of CREB protein 2
 Protein Family    CREB-regulated transcription coactivator
 UniProt Gene Name    Crtc2 [Similar Products]
 UniProt Synonym Gene Names    Torc2; TORC-2; Transducer of CREB protein 2 [Similar Products]
 UniProt Entry Name    CRTC2_MOUSE
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 UniProt Comments for CRTC2    TORC2: the transducer of regulated CREB protein 2 (TORC2) is a cAMP responsive coactivator that, in concert with LKB1 and AMPK, controls glucose homeostasis in the liver. Under fasting conditions, cytoplasmic TORC2 is transported to the nucleus where it binds to CREB and stimulates gluconeogenisis. Re-feeding and the ensuing insulin response inhibits gluconeogenic gene expression by promoting the phosphorylation, cytoplasmic export and degradation of TORC2. TORC2 is phosphorylated by the kinase QIK which in turn is activated by phosphorylation at Ser358 by insulin-activated Akt2. Phosphorylated TORC2 is subsequently ubiquitinylated at Lys 628 and degraded by the 26S proteasome. TORC2 protein levels and activity are increased in diabetes owing to a block in TORC2 phosphorylation, implicating this pathway in the pathogenesis of diabetes. The CREB/TORC2 regulatory axis controls the normal pattern of germinal center (GC) B cell gene activation/repression that promotes B cell development and circumvents GC lymphomagenesis.

Protein type: Transcription, coactivator/corepressor

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: cAMP response element binding protein binding; chromatin binding; protein binding

Biological Process: activation of CREB transcription factor; gluconeogenesis; glucose homeostasis; positive regulation of transcription from RNA polymerase II promoter; protein homotetramerization; regulation of transcription, DNA-dependent; transcription, DNA-dependent
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 Research Articles on CRTC2    1. CRTC2 promotes Th17 cell differentiation via stimulation of IL-17A and IL-17F expression by binding to CREB over both promoters. CRTC2-mutant mice have decreased Th17 cells, and they are protected from experimental autoimmune encephalitis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CRTC2 antibodyPathways associated with anti-CRTC2 antibody
 Reference Product  PubMed Publications
 Creb1 antibody  >25 publications with CRTC2 and Creb1
 Akt1 antibody  >13 publications with CRTC2 and Akt1
 Sik2 antibody  >13 publications with CRTC2 and Sik2
 Akt2 antibody  >8 publications with CRTC2 and Akt2
 Sik3 antibody  >3 publications with CRTC2 and Sik3
 Creb3l3 antibody  >1 publications with CRTC2 and Creb3l3
 Prkaa2 antibody  >1 publications with CRTC2 and Prkaa2
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Insulin Resistance Pathway antibodies  Insulin Resistance Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
Diseases associated with anti-CRTC2 antibodyOrgans/Tissues associated with anti-CRTC2 antibody
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >34 publications with CRTC2 and Insulin Resistance
 Hyperglycemia Antibodies  >25 publications with CRTC2 and Hyperglycemia
 Carcinoma Antibodies  >16 publications with CRTC2 and Carcinoma
 Immune System Diseases Antibodies  >16 publications with CRTC2 and Immune System Diseases
 Kidney Diseases Antibodies  >15 publications with CRTC2 and Kidney Diseases
 Cell Transformation, Neoplastic Antibodies  >12 publications with CRTC2 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >11 publications with CRTC2 and Neoplasms, Experimental
 Glucose Intolerance Antibodies  >9 publications with CRTC2 and Glucose Intolerance
 Liver Diseases Antibodies  >8 publications with CRTC2 and Liver Diseases
 Fatty Liver Antibodies  >8 publications with CRTC2 and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >69 publications with CRTC2 and Liver
 Brain Antibodies  >26 publications with CRTC2 and Brain
 Kidney Antibodies  >25 publications with CRTC2 and Kidney
 Pancreas Antibodies  >12 publications with CRTC2 and Pancreas
 Lung Antibodies  >11 publications with CRTC2 and Lung
 Embryonic Tissue Antibodies  >10 publications with CRTC2 and Embryonic Tissue
 Heart Antibodies  >5 publications with CRTC2 and Heart
 Bone Marrow Antibodies  >4 publications with CRTC2 and Bone Marrow
 Eye Antibodies  >4 publications with CRTC2 and Eye
 Skin Antibodies  >3 publications with CRTC2 and Skin
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