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anti-CRYBA1 antibody :: Rabbit anti-Human CRYBA1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7006779
Western Blot (WB)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CRYBA1, Polyclonal Antibody

★Popular Item★
 Also Known As   

CRYBA1 Antibody

 Product Synonym Names    Beta-crystallin A3Cleaved into the following 3 chains:Beta-crystallin A3; isoform A1; Delta4 formBeta-crystallin A3; isoform A1; Delta7 formBeta-crystallin A3; isoform A1; Delta8 form; CRYBA1; CRYB1
 Product Gene Name   

anti-CRYBA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    123610
 3D Structure    ModBase 3D Structure for P05813
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%,Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Beta-crystallin A3 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-22398
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CRYBA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CRYBA1 antibody

   Crystallins are the dominant structural components of the vertebrate eye lens.
 Applications Tested/Suitable for anti-CRYBA1 antibody   

ELISA (EIA), Western Blot (WB)

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 Western Blot (WB) of anti-CRYBA1 antibody    Western blot
All lanes: CRYBA1 antibody at 6ug/ml
Lane 1: Mouse heart tissue
Lane 2: Human placenta tissue
Lane 3: U251 whole cell lysate
Lane 4: U937 whole cell lysate
Lane 5: Mouse stomach tissue
Lane 6: Mouse liver tissue
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 26,24 kDa
Observed band size: 25 kDa

anti-CRYBA1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CRYBA1. It may not necessarily be applicable to this product.
 NCBI GI #    12056461
 NCBI GeneID    1411
 NCBI Accession #    NP_005199.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005208.4 [Other Products]
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 UniProt Primary Accession #    P05813 [Other Products]
 UniProt Secondary Accession #    Q13633; Q14CM9 [Other Products]
 UniProt Related Accession #    P05813 [Other Products]
 Molecular Weight    23,191 Da
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 NCBI Official Full Name    beta-crystallin A3
 NCBI Official Synonym Full Names    crystallin beta A1
 NCBI Official Symbol    CRYBA1 [Similar Products]
 NCBI Official Synonym Symbols   
CRYB1; CTRCT10
[Similar Products]
 NCBI Protein Information    beta-crystallin A3
 UniProt Protein Name    Beta-crystallin A3
 Protein Family    Beta-crystallin
 UniProt Gene Name    CRYBA1 [Similar Products]
 UniProt Synonym Gene Names    CRYB1 [Similar Products]
 UniProt Entry Name    CRBA1_HUMAN
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 NCBI Summary for CRYBA1    Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, encodes two proteins (crystallin, beta A3 and crystallin, beta A1) from a single mRNA, the latter protein is 17 aa shorter than crystallin, beta A3 and is generated by use of an alternate translation initiation site. Deletion of exons 3 and 4 causes the autosomal dominant disease 'zonular cataract with sutural opacities'. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CRYBA1    CRYBA1: a major structural protein of the eye lens. A member of the beta/gamma-crystallin family. Defects are the cause of congenital zonular cataract with sutural opacities. Two splice-variant isoforms have been described.

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; protein homodimerization activity; structural constituent of eye lens

Biological Process: lens development in camera-type eye; negative regulation of cytokine production; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of protein kinase B signaling cascade; negative regulation of TOR signaling pathway; visual perception

Disease: Cataract 10, Multiple Types
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 Research Articles on CRYBA1    1. association between a frameshift mutation in exon 6 of CRYBA1/A3 and congenital cataracts
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CRYBA1 antibodyDiseases associated with anti-CRYBA1 antibody
 Reference Product  PubMed Publications
 CRYBB2 antibody  >20 publications with CRYBA1 and CRYBB2
 CRYBB1 antibody  >20 publications with CRYBA1 and CRYBB1
 CRYAA antibody  >17 publications with CRYBA1 and CRYAA
 CRYAB antibody  >14 publications with CRYBA1 and CRYAB
 CRYBB3 antibody  >12 publications with CRYBA1 and CRYBB3
 GJA8 antibody  >11 publications with CRYBA1 and GJA8
 GJA3 antibody  >9 publications with CRYBA1 and GJA3
 LIM2 antibody  >5 publications with CRYBA1 and LIM2
 GALK1 antibody  >1 publications with CRYBA1 and GALK1
 Disease Name  Pubmed Publications
 Cataract, Congenital Zonular, with Sutural Opacities Antibodies  >2 publications with CRYBA1 and Cataract, Congenital Zonular, with Sutural Opacities
 Nervous System Diseases Antibodies  >1 publications with CRYBA1 and Nervous System Diseases
 Carcinoma Antibodies  >1 publications with CRYBA1 and Carcinoma
 Cardiovascular Diseases Antibodies  >1 publications with CRYBA1 and Cardiovascular Diseases
 Nerve Degeneration Antibodies  >1 publications with CRYBA1 and Nerve Degeneration
 Hypertension Antibodies  >1 publications with CRYBA1 and Hypertension
 Infertility, Male Antibodies  >1 publications with CRYBA1 and Infertility, Male
 Weight Loss Antibodies  >1 publications with CRYBA1 and Weight Loss
 Inflammation Antibodies  >1 publications with CRYBA1 and Inflammation
Organs/Tissues associated with anti-CRYBA1 antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >55 publications with CRYBA1 and Eye
 Skin Antibodies  >2 publications with CRYBA1 and Skin
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