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anti-CRYBB2 antibody :: Rabbit CRYBB2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2521623
Testing Data
Unit / Price
0.06 mL  /  $195 +1 FREE 8GB USB
0.12 mL  /  $270 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CRYBB2, Polyclonal Antibody

★Popular Item★
 Also Known As   

CRYBB2 Antibody

 Product Synonym Names    Beta B2 crystallin, Beta crystallin B2, Beta crystallin Bp, CCA2, CRYB2, CRYB2A, CRYBB2, crystallin, beta B2, D22S665
 Product Gene Name   

anti-CRYBB2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    123620
 3D Structure    ModBase 3D Structure for BC069535
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
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 Immunogen    Fusion protein of CRYBB2
 Calculated MW    205aa,23 kDa
 Observed MW    24 kDa
 Buffer    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 Other Notes    Small volumes of anti-CRYBB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CRYBB2 antibody

   Crystallins are the dominant structural components of the vertebrate eye lens.
 Applications Tested/Suitable for anti-CRYBB2 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-CRYBB2 antibody    WB: 1:200-1:1000
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 Testing Data of anti-CRYBB2 antibody    mouse brain tissue were subjected to SDS PAGE followed by western blot with CRYBB2 Polyclonal Antibody at dilution of 1:300
anti-CRYBB2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CRYBB2. It may not necessarily be applicable to this product.
 NCBI GI #    47678383
 NCBI GeneID    1415
 NCBI Accession #    CAG30312.1 [Other Products]
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 UniProt Primary Accession #    BC069535 [Other Products]
 UniProt Secondary Accession #    Q9UCM8 [Other Products]
 UniProt Related Accession #    P43320 [Other Products]
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 NCBI Official Full Name    CRYBB2
 NCBI Official Synonym Full Names    crystallin, beta B2
 NCBI Official Symbol    CRYBB2 [Similar Products]
 NCBI Official Synonym Symbols   
CCA2; CRYB2; CRYB2A; CTRCT3; D22S665
[Similar Products]
 NCBI Protein Information    beta-crystallin B2; beta-B2 crystallin; beta-crystallin Bp; eye lens structural protein
 UniProt Protein Name    Beta-crystallin B2
 UniProt Synonym Protein Names   
Beta-B2 crystallin; Beta-crystallin Bp
 Protein Family    Beta-crystallin
 UniProt Gene Name    CRYBB2 [Similar Products]
 UniProt Synonym Gene Names    CRYB2; CRYB2A [Similar Products]
 UniProt Entry Name    CRBB2_HUMAN
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 NCBI Summary for CRYBB2    Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A chain-terminating mutation was found to cause type 2 cerulean cataracts. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CRYBB2    CRYBB2: a major structural protein of the eye lens. A member of the beta/gamma-crystallin family. Defects are the cause of congenital cerulean type 2 cataract, sutural cataract with punctate and cerulean opacities, and Coppock-like cataract.

Chromosomal Location of Human Ortholog: 22q11.23

Molecular Function: identical protein binding; protein homodimerization activity; structural molecule activity; structural constituent of eye lens

Biological Process: camera-type eye development; visual perception; response to stimulus

Disease: Cataract 3, Multiple Types
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 Research Articles on CRYBB2    1. missense mutation in CRYBB2 gene leads to progressive congenital membranous cataract by impacting the solubility and function of betaB2-crystallin
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CRYBB2 antibodyPathways associated with anti-CRYBB2 antibody
 Reference Product  PubMed Publications
 CRYAA antibody  >21 publications with CRYBB2 and CRYAA
 CRYBA4 antibody  >20 publications with CRYBB2 and CRYBA4
 CRYBB3 antibody  >20 publications with CRYBB2 and CRYBB3
 CRYBA1 antibody  >19 publications with CRYBB2 and CRYBA1
 CRYGC antibody  >15 publications with CRYBB2 and CRYGC
 GJA8 antibody  >15 publications with CRYBB2 and GJA8
 CRYAB antibody  >14 publications with CRYBB2 and CRYAB
 GJA3 antibody  >11 publications with CRYBB2 and GJA3
 CRYBA2 antibody  >5 publications with CRYBB2 and CRYBA2
 Products by Pathway  Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
Diseases associated with anti-CRYBB2 antibodyOrgans/Tissues associated with anti-CRYBB2 antibody
 Disease Name  Pubmed Publications
 Cerulean cataract Antibodies  >6 publications with CRYBB2 and Cerulean cataract
 Cardiovascular Diseases Antibodies  >2 publications with CRYBB2 and Cardiovascular Diseases
 Intestinal Neoplasms Antibodies  >1 publications with CRYBB2 and Intestinal Neoplasms
 Brain Diseases Antibodies  >1 publications with CRYBB2 and Brain Diseases
 Inflammation Antibodies  >1 publications with CRYBB2 and Inflammation
 Heart Diseases Antibodies  >1 publications with CRYBB2 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >43 publications with CRYBB2 and Eye
 Testis Antibodies  >2 publications with CRYBB2 and Testis
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