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anti-CSF2RB antibody :: Rabbit CSF2RB / CD131 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS247912
Unit / Price
0.05 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CSF2RB / CD131, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal (IgG) to Human CSF2RB / CD131

 Product Synonym Names    Anti-CSF2RB / CD131 Antibody (aa559-608) IHC-plus; CSF2RB; CD131 antigen; CDw131; IL3RB; IL5RB; SMDP5; CD131; GM-CSF receptor beta chain; Human CSF2RB; CD131
 Product Gene Name   

anti-CSF2RB antibody

[Similar Products]
 Product Synonym Gene Name    CD131 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 614370
 3D Structure    ModBase 3D Structure for P32927
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    IL-3R beta antibody detects endogenous levels of total IL-3R beta protein.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human IL-3R beta (aa559-608).
 Immunogen    CSF2RB / CD131 antibody was raised against synthetic peptide from human IL-3R beta (aa559-608).
 Antigen Modification    aa559-608
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-CSF2RB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CSF2RB antibody

   CSF2RB is a common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defective CSF2RB has been reported to be associated with protein alveolar proteinosis.
 Applications Tested/Suitable for anti-CSF2RB antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CSF2RB antibody    ELISA (1:1000), IHC-P (10 ug/ml), WB (1:500 - 1:1000)
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 Immunohistochemistry (IHC) of anti-CSF2RB antibody    Anti-CSF2RB / CD131 antibody IHC of human spleen, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-CSF2RB antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-CSF2RB antibody    Western blot of extracts from Raw264.7 cells, treated with G-CSF 25 ng/ml 15', using IL-3R beta antibody. The lane on the right is treated with the synthesized peptide.
anti-CSF2RB antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CSF2RB. It may not necessarily be applicable to this product.
 NCBI GI #    4559408
 NCBI GeneID    1439
 NCBI Accession #    NP_000386.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000395.2 [Other Products]
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 UniProt Primary Accession #    P32927 [Other Products]
 UniProt Secondary Accession #    Q5JZI1; Q6ICE0 [Other Products]
 UniProt Related Accession #    P32927 [Other Products]
 Molecular Weight    97,976 Da
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 NCBI Official Full Name    cytokine receptor common subunit beta
 NCBI Official Synonym Full Names    colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
 NCBI Official Symbol    CSF2RB [Similar Products]
 NCBI Official Synonym Symbols   
CD131; IL3RB; IL5RB; SMDP5; CDw131
[Similar Products]
 NCBI Protein Information    cytokine receptor common subunit beta; GM-CSF/IL-3/IL-5 receptor common beta-chain; GM-CSF/IL-3/IL-5 receptor common beta subunit; colony-stimulating factor-2 receptor, beta, low-affinity; interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity)
 UniProt Protein Name    Cytokine receptor common subunit beta
 UniProt Synonym Protein Names   
CDw131; GM-CSF/IL-3/IL-5 receptor common beta subunit; CD_antigen: CD131
 Protein Family    Cytokine receptor
 UniProt Gene Name    CSF2RB [Similar Products]
 UniProt Synonym Gene Names    IL3RB; IL5RB [Similar Products]
 UniProt Entry Name    IL3RB_HUMAN
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 NCBI Summary for CSF2RB    The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]
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 UniProt Comments for CSF2RB    CSF2RB: a common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. A type I cytokine family of receptor. Defects are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: granulocyte macrophage colony-stimulating factor receptor complex; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; interleukin-5 receptor activity; interleukin-3 receptor activity; receptor activity

Biological Process: response to lipopolysaccharide; respiratory gaseous exchange; signal transduction

Disease: Surfactant Metabolism Dysfunction, Pulmonary, 5
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 Research Articles on CSF2RB    1. VitD-mediated stimulation of GC anti-inflammatory affects human monocytes in a process involving GM-CSF and MED14
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CSF2RB antibodyPathways associated with anti-CSF2RB antibody
 Reference Product  PubMed Publications
 IL5RA antibody  >38 publications with CSF2RB and IL5RA
 JAK2 antibody  >26 publications with CSF2RB and JAK2
 IL3 antibody  >10 publications with CSF2RB and IL3
 CSF2 antibody  >10 publications with CSF2RB and CSF2
 CSF2RA antibody  >7 publications with CSF2RB and CSF2RA
 LYN antibody  >5 publications with CSF2RB and LYN
 IL5 antibody  >5 publications with CSF2RB and IL5
 SHC1 antibody  >4 publications with CSF2RB and SHC1
 PTPN11 antibody  >1 publications with CSF2RB and PTPN11
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Beta:gamma Signalling Through PI3Kgamma Pathway antibodies  G Beta:gamma Signalling Through PI3Kgamma Pathway Diagram
 G-protein Beta:gamma Signalling Pathway antibodies  G-protein Beta:gamma Signalling Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPVI-mediated Activation Cascade Pathway antibodies  GPVI-mediated Activation Cascade Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-CSF2RB antibodyOrgans/Tissues associated with anti-CSF2RB antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >34 publications with CSF2RB and Inflammation
 Lung Diseases Antibodies  >17 publications with CSF2RB and Lung Diseases
 Respiratory Tract Diseases Antibodies  >15 publications with CSF2RB and Respiratory Tract Diseases
 Asthma Antibodies  >13 publications with CSF2RB and Asthma
 Necrosis Antibodies  >10 publications with CSF2RB and Necrosis
 Liver Diseases Antibodies  >5 publications with CSF2RB and Liver Diseases
 Heart Diseases Antibodies  >5 publications with CSF2RB and Heart Diseases
 Neoplasms, Experimental Antibodies  >5 publications with CSF2RB and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >4 publications with CSF2RB and Liver Neoplasms
 Fibrosis Antibodies  >3 publications with CSF2RB and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >118 publications with CSF2RB and Blood
 Bone Antibodies  >27 publications with CSF2RB and Bone
 Lung Antibodies  >24 publications with CSF2RB and Lung
 Bone Marrow Antibodies  >24 publications with CSF2RB and Bone Marrow
 Vascular Antibodies  >14 publications with CSF2RB and Vascular
 Brain Antibodies  >12 publications with CSF2RB and Brain
 Skin Antibodies  >9 publications with CSF2RB and Skin
 Intestine Antibodies  >7 publications with CSF2RB and Intestine
 Muscle Antibodies  >6 publications with CSF2RB and Muscle
 Lymph Node Antibodies  >4 publications with CSF2RB and Lymph Node
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