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anti-COPS2 antibody :: Goat CSN2/TRIP15 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421138
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CSN2/TRIP15 (COPS2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-CSN2/TRIP15 Antibody

 Product Synonym Names    COPS2; TRIP15; COPS2; CSN2; thyroid receptor interacting protein 15; SGN2; COP9 constitutive photomorphogenic homolog subunit 2; thyroid receptor interacting protein 15; COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis); COP9, subunit 2; COPS2 antibody; TRIP15 antibody; COPS2 antibody; CSN2 antibody; thyroid receptor interacting protein 15 antibody; SGN2 antibody; COP9 constitutive photomorphogenic homolog subunit 2 antibody; thyroid receptor interacting protein 15 antibody; COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) antibody; COP9; subunit 2 antibody; ALIEN antibody; COP9 signalosome complex subunit 2 antibody; JAB1-containing signalosome subunit 2 antibody; CSN2 / TRIP15
 Product Gene Name   

anti-COPS2 antibody

[Similar Products]
 Product Synonym Gene Name    CSN2; TRIP15 [Similar Products]
 Antibody/Peptide Pairs    CSN2 / TRIP15 peptide (MBS425841) is used for blocking the activity of CSN2/TRIP15 antibody (MBS421138)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    LNSLNQAVVS KLA
 OMIM    604508
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-LNSLNQAVVSKLA, from the C Terminus of the protein sequence according to NP_004227.1; NP_001137359.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-COPS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-COPS2 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-COPS2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Immunohistochemistry: In paraffin embedded Human Thyroid Gland shows nclear and cytoplasm staining in activated epithelial cells Recommended concentration, 3-5ug/ml.
Western Blot: approx. 48kDa band observed in Human Brain, Mouse Brain lysates and in lysates of Mouse putuitary cell line NIH3T3 (calculated MW of 51.6kDa according to NP_004227.1). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-COPS2 antibody    Staining (0. 03ug/ml) of NIH-3T3 lysates (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-COPS2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-COPS2 antibody    In paraffin embedded Human Thyroid Gland shows nclear and cytoplasm staining in activated epithelial cells Recommended concentration, 3-5ug/ml.
anti-COPS2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for COPS2. It may not necessarily be applicable to this product.
 NCBI GI #    4759264
 NCBI GeneID    9318
 NCBI Accession #    NP_004227.1 [Other Products]
 NCBI Related Accession #    NP_001137359.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004236.3 [Other Products]
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 UniProt Secondary Accession #    O88950; Q15647; Q6FGP4; Q9BY54; Q9R249; Q9UNI2; Q9UNQ5 [Other Products]
 UniProt Related Accession #    P61201 [Other Products]
 Molecular Weight    52,405 Da
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 NCBI Official Full Name    COP9 signalosome complex subunit 2 isoform 1
 NCBI Official Synonym Full Names    COP9 signalosome subunit 2
 NCBI Official Symbol    COPS2 [Similar Products]
 NCBI Official Synonym Symbols   
CSN2; SGN2; ALIEN; TRIP15
[Similar Products]
 NCBI Protein Information    COP9 signalosome complex subunit 2
 UniProt Protein Name    COP9 signalosome complex subunit 2
 UniProt Synonym Protein Names   
Alien homolog; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15
 UniProt Gene Name    COPS2 [Similar Products]
 UniProt Synonym Gene Names    CSN2; TRIP15; SGN2; Signalosome subunit 2; TR-interacting protein 15; TRIP-15 [Similar Products]
 UniProt Entry Name    CSN2_HUMAN
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 UniProt Comments for COPS2    COPS2: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. Belongs to the CSN2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 15q21.2

Cellular Component: cytoplasm; nucleoplasm; signalosome

Molecular Function: protein binding; signal transducer activity; transcription corepressor activity

Biological Process: cell proliferation; cullin deneddylation; negative regulation of transcription from RNA polymerase II promoter; neuron differentiation; nucleotide-excision repair, DNA damage recognition; signal transduction; transcription from RNA polymerase II promoter; transcription-coupled nucleotide-excision repair
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Product References and Citations for anti-COPS2 antibody

   Besse A, Campos AD, Webster WK, Darnay BG.; TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase.; Biochem Biophys Res Commun.2007 Aug 3;359(3): 660-4.; Pubmed 17544371
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 Research Articles on COPS2    1. CSN2 knockdown cells underwent non-apoptotic cell death.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-COPS2 antibodyPathways associated with anti-COPS2 antibody
 Reference Product  PubMed Publications
 COPS5 antibody  >4 publications with COPS2 and COPS5
 CUL1 antibody  >2 publications with COPS2 and CUL1
 COPS6 antibody  >2 publications with COPS2 and COPS6
 COPS4 antibody  >2 publications with COPS2 and COPS4
 COPS8 antibody  >1 publications with COPS2 and COPS8
 COPS7A antibody  >1 publications with COPS2 and COPS7A
 COPS3 antibody  >1 publications with COPS2 and COPS3
 GPS1 antibody  >1 publications with COPS2 and GPS1
 Products by Pathway  Pathway Diagram
 DNA Damage Recognition In GG-NER Pathway antibodies  DNA Damage Recognition In GG-NER Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Formation Of TC-NER Pre-Incision Complex Pathway antibodies  Formation Of TC-NER Pre-Incision Complex Pathway Diagram
 Global Genome Nucleotide Excision Repair (GG-NER) Pathway antibodies  Global Genome Nucleotide Excision Repair (GG-NER) Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Transcription-Coupled Nucleotide Excision Repair (TC-NER) Pathway antibodies  Transcription-Coupled Nucleotide Excision Repair (TC-NER) Pathway Diagram
Diseases associated with anti-COPS2 antibodyOrgans/Tissues associated with anti-COPS2 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >3 publications with COPS2 and Carcinoma
 Breast Neoplasms Antibodies  >1 publications with COPS2 and Breast Neoplasms
 Genital Diseases, Male Antibodies  >1 publications with COPS2 and Genital Diseases, Male
 Prostatic Neoplasms Antibodies  >1 publications with COPS2 and Prostatic Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with COPS2 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >14 publications with COPS2 and Thyroid
 Brain Antibodies  >3 publications with COPS2 and Brain
 Blood Antibodies  >2 publications with COPS2 and Blood
 Embryonic Tissue Antibodies  >2 publications with COPS2 and Embryonic Tissue
 Adrenal Gland Antibodies  >1 publications with COPS2 and Adrenal Gland
 Intestine Antibodies  >1 publications with COPS2 and Intestine
 Muscle Antibodies  >1 publications with COPS2 and Muscle
 Prostate Antibodies  >1 publications with COPS2 and Prostate
 Liver Antibodies  >1 publications with COPS2 and Liver
 Testis Antibodies  >1 publications with COPS2 and Testis
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