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anti-CSNK2A1 antibody :: Rabbit CSNK2A1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2527004
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CSNK2A1, Polyclonal Antibody

★Popular Item★
 Also Known As   

CSNK2A1 Polyclonal Antibody

 Product Synonym Names    CKII; CK2A1; CSNK2A3
 Product Gene Name   

anti-CSNK2A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    115440
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    1.2mg/mL (lot specific)
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 Immunogen    Recombinant protein of human CSNK2A1
 Calculated Molecular Weight: 45kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CSNK2A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CSNK2A1 antibody

   Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene.
 Product Categories/Family for anti-CSNK2A1 antibody    Cell biology
 Applications Tested/Suitable for anti-CSNK2A1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CSNK2A1 antibody    WB: 1:500-1:2000
IHC: 1:25-1:100
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 Western Blot (WB) of anti-CSNK2A1 antibody    Western Blot analysis of K562 and 293T cell, Jurkat cell and Mouse brain tissue using CSNK2A1 Polyclonal Antibody at dilution of 1:300
anti-CSNK2A1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CSNK2A1 antibody    Immunohistochemistry of paraffin-embedded Human liver cancer using CSNK2A1 Polyclonal Antibody at dilution of 1:30
anti-CSNK2A1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CSNK2A1. It may not necessarily be applicable to this product.
 NCBI GI #    55249572
 NCBI GeneID    1457
 NCBI Accession #    AAH50036.1 [Other Products]
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 UniProt Secondary Accession #    P19138; P20426; Q14013; Q5U065; B4DYS6; D3DVV8 [Other Products]
 UniProt Related Accession #    P68400; Q8NEV1 [Other Products]
 Molecular Weight    29,181 Da
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 NCBI Official Full Name    CSNK2A1 protein
 NCBI Official Synonym Full Names    casein kinase 2, alpha 1 polypeptide
 NCBI Official Symbol    CSNK2A1 [Similar Products]
 NCBI Official Synonym Symbols   
CKII; CK2A1; CSNK2A3
[Similar Products]
 NCBI Protein Information    casein kinase II subunit alpha; CK II alpha 3; CK2 catalytic subunit alpha; casein kinase II alpha 1 polypeptide pseudogene; casein kinase II alpha 1 subunit; protein kinase CK2
 UniProt Protein Name    Casein kinase II subunit alpha
 Protein Family    Casein kinase
 UniProt Gene Name    CSNK2A1 [Similar Products]
 UniProt Synonym Gene Names    CK2A1; CK II alpha [Similar Products]
 UniProt Entry Name    CSK21_HUMAN
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 NCBI Summary for CSNK2A1    Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014]
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 UniProt Comments for CSNK2A1    CK2A1: an ubiquitous protein kinase of the CK2 family. Exists as a tetramer composed of two catalytic subunits, alpha and alpha-prime, and two regulatory beta subunits. The beta subunits undergo autophosphorylation. The isoforms are rarely specified in publications. Two splice variant isoforms have been found. Participates in Wnt signaling. Phosphorylates E2 ubiquitin conjugating enzyme UBC3B inducing its interaction with beta-TRCp and enhancing beta-catenin degradation. May control IkB-alpha and p27Kip1 degradation. component of a CK2-SPT16-SSRP1 complex composed of SSRP1, PT16 CK2-A1, CK2-A2 and CK2-B the complex associating following UV irradiation. Interacts with RNPS1. Mouse transgene causes mammary gland hyperplasia and lymphoma, and activation by bovine parasites leads to fatal lymphoproliferation. Expression and activity are elevated in lung tumors and breast tumors. Antisense drives apoptosis of tumor cell lines and xenografts. Involved in DNA break repair by phosphorylation of scaffold protein XRCC1, phosphorylation of BRCA1, and phosphorylation of p53 in response to UV irradiation. Drosophila CK2 (Timekeeper) is involved in circadian regulation. Phosphorylates and binds to a major component of the inclusion bodies seen in Parkinson?s patients. Inhibitors: 4,5,6,7-tetrabromobenzotriazole (TBB).

Protein type: Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Other group; CK2 family

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: Sin3 complex; plasma membrane; NuRD complex; PcG protein complex; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; protein N-terminus binding; Hsp90 protein binding; ATP binding

Biological Process: axon guidance; Wnt receptor signaling pathway; transcription, DNA-dependent; rhythmic process; negative regulation of caspase activity; signal transduction; protein amino acid phosphorylation; positive regulation of cell growth; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of protein catabolic process; mitotic cell cycle; positive regulation of Wnt receptor signaling pathway
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 Research Articles on CSNK2A1    1. the inhibition of protein kinase CK2 transiently inhibits cell proliferation through the induction of G1 cell cycle arrest and attenuation of protein synthesis by phosphorylating eIF2 alpha.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CSNK2A1 antibodyPathways associated with anti-CSNK2A1 antibody
 Reference Product  PubMed Publications
 JUN antibody  >1 publications with CSNK2A1 and JUN
 CSNK2B antibody  >1 publications with CSNK2A1 and CSNK2B
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Condensation Of Prometaphase Chromosomes Pathway antibodies  Condensation Of Prometaphase Chromosomes Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
Diseases associated with anti-CSNK2A1 antibodyOrgans/Tissues associated with anti-CSNK2A1 antibody
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >3 publications with CSNK2A1 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >2 publications with CSNK2A1 and Neoplasms, Experimental
 Brain Diseases Antibodies  >2 publications with CSNK2A1 and Brain Diseases
 Nervous System Diseases Antibodies  >2 publications with CSNK2A1 and Nervous System Diseases
 Anemia Antibodies  >1 publications with CSNK2A1 and Anemia
 Weight Gain Antibodies  >1 publications with CSNK2A1 and Weight Gain
 Anemia, Hemolytic Antibodies  >1 publications with CSNK2A1 and Anemia, Hemolytic
 Fever Antibodies  >1 publications with CSNK2A1 and Fever
 Carcinoma, Squamous Cell Antibodies  >1 publications with CSNK2A1 and Carcinoma, Squamous Cell
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >3 publications with CSNK2A1 and Lung
 Bone Antibodies  >2 publications with CSNK2A1 and Bone
 Bone Marrow Antibodies  >1 publications with CSNK2A1 and Bone Marrow
 Blood Antibodies  >1 publications with CSNK2A1 and Blood
 Connective Tissue Antibodies  >1 publications with CSNK2A1 and Connective Tissue
 Embryonic Tissue Antibodies  >1 publications with CSNK2A1 and Embryonic Tissue
 Lymph Node Antibodies  >1 publications with CSNK2A1 and Lymph Node
 Mammary Gland Antibodies  >1 publications with CSNK2A1 and Mammary Gland
 Lymph Antibodies  >1 publications with CSNK2A1 and Lymph
 Testis Antibodies  >1 publications with CSNK2A1 and Testis
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