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anti-CSNK2A2 antibody :: Rabbit anti-Human CSNK2A2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6009848 anti-CSNK2A2 antibody
Unit / Price
0.1 mg  /  $615 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CSNK2A2, Polyclonal Antibody

 Also Known As   

CSNK2A2 (Casein Kinase II Subunit alpha', CK II alpha', CK2A2)

 Product Synonym Names    Anti -CSNK2A2 (Casein Kinase II Subunit alpha', CK II alpha', CK2A2)
 Product Gene Name   

anti-CSNK2A2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    MPGPAAGSRA RVYAEVNSLR SREYWDYEAH VPSWGNQDDY QLVRKLGRGK YSEVFEAINI TNNERVVVKI LKPVKKKKIK REVKILENLR GGTNIIKLID TVKDPVSKTP ALVFEYINNT DFKQLYQILT DFDIRFYMYE LLKALDYCHS KGIMHRDVKP HNVMIDHQQK KLRLIDWGLA EFYHPAQEYN VRVASRYFKG PELLVDYQMY DYSLDMWSLG CMLASMIFRR EPFFHGQDNY DQLVRIAKVL GTEELYGYLK KYHIDLDPHF NDILGQHSRK RWENFIHSEN RHLVSPEALD LLDKLLRYDH QQRLTAKEAM EHPYFYPVVK EQSQPCADNA VLSSGLTAAR
 Chromosome Location    Chromosome: 18; AC_000175.1 (26098512..26132552, complement). Location: chromosome: 18
 3D Structure    ModBase 3D Structure for P20427
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human CSNK2A2.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2.
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 Immunogen    Full length human CSNK2A2, aa1-350 (NP_001887.1).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-CSNK2A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CSNK2A2 antibody

   Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).
 Product Categories/Family for anti-CSNK2A2 antibody    Antibodies; Abs to Protein Kinases
 Applications Tested/Suitable for anti-CSNK2A2 antibody   

Western Blot (WB)

 Application Notes for anti-CSNK2A2 antibody    Suitable for use in Western Blot.
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NCBI/Uniprot data below describe general gene information for CSNK2A2. It may not necessarily be applicable to this product.
 NCBI GI #    27807145
 NCBI GeneID    282420
 NCBI Accession #    NP_777061.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_174636.2 [Other Products]
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 UniProt Primary Accession #    P20427 [Other Products]
 UniProt Related Accession #    P20427 [Other Products]
 Molecular Weight    41,270 Da [Similar Products]
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 NCBI Official Full Name    casein kinase II subunit alpha'
 NCBI Official Synonym Full Names    casein kinase 2, alpha prime polypeptide<
 NCBI Official Symbol    CSNK2A2 [Similar Products]
 NCBI Protein Information    casein kinase II subunit alpha'; CK II alpha'
 UniProt Protein Name    Casein kinase II subunit alpha'
 Protein Family    Casein kinase
 UniProt Gene Name    CSNK2A2 [Similar Products]
 UniProt Synonym Gene Names    CK II alpha' [Similar Products]
 UniProt Entry Name    CSK22_BOVIN
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 UniProt Comments for CSNK2A2    Function: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins

By similarity.

Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation: Constitutively active protein kinase whose activity is not directly affected by phosphorylation. Seems to be regulated by level of expression and localization

By similarity.

Subunit structure: Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory subunits (beta chains). The tetramer can exist as a combination of 2 alpha/2 beta, 2 alpha'/2 beta or 1 alpha/1 alpha'/2 beta subunits. Also part of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, which forms following UV irradiation. Interacts with RNPS1

By similarity.

Miscellaneous: Can use both ATP and GTP as phosphoryl donors. Phosphorylation by casein kinase 2 has been estimated to represent up to one quarter of the eukaryotic phosphoproteome.

Sequence similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.Contains 1 protein kinase domain.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CSNK2A2 antibodyPathways associated with anti-CSNK2A2 antibody
 Reference Product  PubMed Publications
 CSNK2B antibody  >2 publications with CSNK2A2 and CSNK2B
 CTNNB1 antibody  >1 publications with CSNK2A2 and CTNNB1
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Condensation Of Prometaphase Chromosomes Pathway antibodies  Condensation Of Prometaphase Chromosomes Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
Diseases associated with anti-CSNK2A2 antibodyOrgans/Tissues associated with anti-CSNK2A2 antibody
 Disease Name  Pubmed Publications
 Infertility, Male Antibodies  >5 publications with CSNK2A2 and Infertility, Male
 Heart Diseases Antibodies  >2 publications with CSNK2A2 and Heart Diseases
 Colonic Neoplasms Antibodies  >2 publications with CSNK2A2 and Colonic Neoplasms
 Cardiovascular Diseases Antibodies  >2 publications with CSNK2A2 and Cardiovascular Diseases
 Neoplasms Antibodies  >2 publications with CSNK2A2 and Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with CSNK2A2 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with CSNK2A2 and Brain
 Kidney Antibodies  >1 publications with CSNK2A2 and Kidney
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