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anti-CST3 antibody :: Rabbit CST3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2517606
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CST3, Polyclonal Antibody

★Popular Item★
 Also Known As   

CST3 Polyclonal Antibody

 Product Synonym Names    ARMD11
 Product Gene Name   

anti-CST3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    105150
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    1.6mg/mL (lot specific)
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 Immunogen    Synthetic peptide of human CST3
 Calculated Molecular Weight: 16kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-CST3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CST3 antibody

   The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease.
 Product Categories/Family for anti-CST3 antibody    Stem cells; Cell biology; Neuroscience
 Applications Tested/Suitable for anti-CST3 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CST3 antibody    WB: 1:1000-1:5000
IHC: 1:50-1:200
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 Western Blot (WB) of anti-CST3 antibody    Western Blot analysis of Human fetal brain tissue using CST3 Polyclonal Antibody at dilution of 1:2400
anti-CST3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CST3 antibody    Immunohistochemistry of paraffin-embedded Human gastic cancer using CST3 Polyclonal Antibody at dilution of 1:50
anti-CST3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CST3. It may not necessarily be applicable to this product.
 NCBI GI #    568599832
 NCBI GeneID    1471
 NCBI Accession #    NP_001275543.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001288614.1 [Other Products]
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 UniProt Secondary Accession #    Q6FGW9; B2R5J9; D3DW42 [Other Products]
 UniProt Related Accession #    P01034 [Other Products]
 Molecular Weight    15,799 Da
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 NCBI Official Full Name    cystatin-C
 NCBI Official Synonym Full Names    cystatin C
 NCBI Official Symbol    CST3 [Similar Products]
 NCBI Official Synonym Symbols   
ARMD11
[Similar Products]
 NCBI Protein Information    cystatin-C; bA218C14.4 (cystatin C); cystatin 3; cystatin-3; gamma-trace; neuroendocrine basic polypeptide; post-gamma-globulin
 UniProt Protein Name    Cystatin-C
 UniProt Synonym Protein Names   
Cystatin-3; Gamma-trace; Neuroendocrine basic polypeptide; Post-gamma-globulin
 Protein Family    Cystatin
 UniProt Gene Name    CST3 [Similar Products]
 UniProt Entry Name    CYTC_HUMAN
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 NCBI Summary for CST3    The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Nov 2014]
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 UniProt Comments for CST3    CST3: As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Defects in CST3 are the cause of amyloidosis type 6 (AMYL6); also known as hereditary cerebral hemorrhage with amyloidosis (HCHWA), cerebral amyloid angiopathy (CAA) or cerebroarterial amyloidosis Icelandic type. AMYL6 is a hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries, arterioles, and sometimes capillaries and veins of the brain, and in various organs including lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral vessels results in cerebral amyloid angiopathy, cerebral hemorrhage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low. Genetic variations in CST3 are associated with age- related macular degeneration type 11 (ARMD11). ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the cystatin family.

Protein type: Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20p11.21

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; protease binding; beta-amyloid binding; endopeptidase inhibitor activity; cysteine protease inhibitor activity

Biological Process: negative regulation of proteolysis; fibril organization and biogenesis; negative regulation of peptidase activity; defense response; regulation of tissue remodeling

Disease: Macular Degeneration, Age-related, 11; Cerebral Amyloid Angiopathy, Cst3-related
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 Research Articles on CST3    1. Serum cystatin C is a reliable marker for estimating glomerular filtration rate among renal transplant recipients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CST3 antibodyPathways associated with anti-CST3 antibody
 Reference Product  PubMed Publications
 APP antibody  >14 publications with CST3 and APP
 CTSB antibody  >8 publications with CST3 and CTSB
 B2M antibody  >6 publications with CST3 and B2M
 APOA1 antibody  >1 publications with CST3 and APOA1
 TTR antibody  >1 publications with CST3 and TTR
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Salivary Secretion Pathway antibodies  Salivary Secretion Pathway Diagram
 Salivary Secretion Pathway antibodies  Salivary Secretion Pathway Diagram
Diseases associated with anti-CST3 antibodyOrgans/Tissues associated with anti-CST3 antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >570 publications with CST3 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >343 publications with CST3 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >226 publications with CST3 and Nervous System Diseases
 Proteinuria Antibodies  >107 publications with CST3 and Proteinuria
 Acute Kidney Injury Antibodies  >105 publications with CST3 and Acute Kidney Injury
 Inflammation Antibodies  >76 publications with CST3 and Inflammation
 Alzheimer Disease Antibodies  >71 publications with CST3 and Alzheimer Disease
 Liver Diseases Antibodies  >51 publications with CST3 and Liver Diseases
 Disease Models, Animal Antibodies  >37 publications with CST3 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >18 publications with CST3 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1013 publications with CST3 and Blood
 Kidney Antibodies  >721 publications with CST3 and Kidney
 Brain Antibodies  >173 publications with CST3 and Brain
 Heart Antibodies  >118 publications with CST3 and Heart
 Vascular Antibodies  >113 publications with CST3 and Vascular
 Liver Antibodies  >88 publications with CST3 and Liver
 Muscle Antibodies  >67 publications with CST3 and Muscle
 Bone Antibodies  >35 publications with CST3 and Bone
 Lung Antibodies  >31 publications with CST3 and Lung
 Nerve Antibodies  >30 publications with CST3 and Nerve
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