NP_001314.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 17 kDa Predicted: 17 kDa
NCBI Official Full Name
cystatin-M
NCBI Official Synonym Full Names
cystatin E/M
NCBI Protein Information
cystatin-M
UniProt Protein Name
Cystatin-M
UniProt Synonym Protein Names
Cystatin-6; Cystatin-E
NCBI Summary for CST6
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq, Jul 2008]
UniProt Comments for CST6
Shows moderate inhibition of cathepsin B but is not active against cathepsin C.
Research Articles on CST6
Precautions
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Disclaimer
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Products associated with anti-CST6 antibody
Diseases associated with anti-CST6 antibody
Organs/Tissues associated with anti-CST6 antibody
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