EAW70615.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1, isoform CRA_a
NCBI Official Synonym Full Names
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
NCBI Protein Information
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; NLI-interacting factor 3; small C-terminal domain phosphatase 1; nuclear LIM interactor-interacting factor 3
UniProt Protein Name
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
UniProt Synonym Protein Names
Nuclear LIM interactor-interacting factor 3; NLI-IF; NLI-interacting factor 3; Small C-terminal domain phosphatase 1; SCP1; Small CTD phosphatase 1
UniProt Synonym Gene Names
NIF3; NLIIF; SCP1; NLI-IF; NLI-interacting factor 3; SCP1; Small CTD phosphatase 1 [Similar Products]
UniProt Entry Name
CTDS1_HUMAN
NCBI Summary for CTDSP1
This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
UniProt Comments for CTDSP1
CTDSP1: Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: nucleus
Molecular Function: protein binding; metal ion binding; CTD phosphatase activity
Biological Process: regulation of transcription from RNA polymerase II promoter; negative regulation of neuron differentiation; negative regulation of protein amino acid phosphorylation; protein amino acid dephosphorylation
Research Articles on CTDSP1
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Products associated with anti-CTDSP1 antibody
Pathways associated with anti-CTDSP1 antibody
Diseases associated with anti-CTDSP1 antibody
Organs/Tissues associated with anti-CTDSP1 antibody
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